SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 LEU B 144
SER B 153
THR B 155
VAL B 158
 None
 1.01A 1dvxB-5nstB:
undetectable		 1dvxB-5nstB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
LIGHT CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 8 ASP A 165
GLY A 101
GLY B  43
GLN B  40
 None
None
None
GOL  A 301 ( 4.3A)
 0.76A 1jr1B-5nstA:
undetectable		 1jr1B-5nstA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5nst LIGHT CHAIN OF
ANTIBODY MGD21
HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TRP B 325
SER B 317
ILE B 347
SER A 116
 None
 1.17A 2xz5A-5nstB:
undetectable
2xz5B-5nstB:
undetectable		 2xz5A-5nstB:
20.44
2xz5B-5nstB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.17A 3jx3A-5nstB:
undetectable
3jx3B-5nstB:
undetectable		 3jx3A-5nstB:
20.54
3jx3B-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.25A 3jx4A-5nstB:
undetectable
3jx4B-5nstB:
undetectable		 3jx4A-5nstB:
20.54
3jx4B-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.23A 3jx5A-5nstB:
undetectable
3jx5B-5nstB:
undetectable		 3jx5A-5nstB:
20.54
3jx5B-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.19A 3nljA-5nstB:
undetectable
3nljB-5nstB:
undetectable		 3nljA-5nstB:
20.54
3nljB-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.21A 3nlpA-5nstB:
undetectable
3nlpB-5nstB:
undetectable		 3nlpA-5nstB:
20.54
3nlpB-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.24A 3nlqA-5nstB:
undetectable
3nlqB-5nstB:
undetectable		 3nlqA-5nstB:
20.54
3nlqB-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		5 / 12 VAL B 300
VAL B 318
SER B 316
ASN B 333
ASN B 292
 None
 1.41A 3nyaA-5nstB:
undetectable		 3nyaA-5nstB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		3 / 3 ARG B  34
HIS B  53
TYR B 235
 None
 1.24A 4fu8A-5nstB:
undetectable		 4fu8A-5nstB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		3 / 3 ARG B  34
HIS B  53
TYR B 235
 None
 1.33A 4fu9A-5nstB:
undetectable		 4fu9A-5nstB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 ASN B  32
VAL B 132
GLU B 167
ARG B 169
 None
None
None
GOL  B 402 (-2.9A)
 1.28A 4mv7A-5nstB:
undetectable		 4mv7A-5nstB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 6 VAL B 204
ARG B 146
VAL B 129
PHE B 183
 None
 1.18A 5adeA-5nstB:
undetectable
5adeB-5nstB:
undetectable		 5adeA-5nstB:
20.54
5adeB-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.26A 5adeA-5nstB:
undetectable
5adeB-5nstB:
undetectable		 5adeA-5nstB:
20.54
5adeB-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.78A 5btaA-5nstB:
undetectable
5btaC-5nstB:
undetectable
5btaD-5nstB:
undetectable		 5btaA-5nstB:
20.98
5btaC-5nstB:
20.98
5btaD-5nstB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 6 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.79A 5btaA-5nstB:
undetectable
5btaB-5nstB:
undetectable
5btaC-5nstB:
undetectable		 5btaA-5nstB:
20.98
5btaB-5nstB:
20.83
5btaC-5nstB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 6 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.85A 5btcA-5nstB:
undetectable
5btcC-5nstB:
undetectable
5btcD-5nstB:
undetectable		 5btcA-5nstB:
20.98
5btcC-5nstB:
20.98
5btcD-5nstB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 6 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.86A 5btcA-5nstB:
undetectable
5btcB-5nstB:
undetectable
5btcC-5nstB:
undetectable		 5btcA-5nstB:
20.98
5btcB-5nstB:
20.83
5btcC-5nstB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.78A 5btfA-5nstB:
undetectable
5btfB-5nstB:
undetectable
5btfC-5nstB:
undetectable		 5btfA-5nstB:
20.98
5btfB-5nstB:
20.83
5btfC-5nstB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 6 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.79A 5btgA-5nstB:
undetectable
5btgB-5nstB:
undetectable
5btgC-5nstB:
undetectable		 5btgA-5nstB:
20.98
5btgB-5nstB:
20.83
5btgC-5nstB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 5 ARG B 134
GLY B 135
THR B 161
GLU B 165
 GOL  B 402 (-3.4A)
None
None
None
 0.86A 5btiC-5nstB:
undetectable
5btiD-5nstB:
undetectable		 5btiC-5nstB:
20.98
5btiD-5nstB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens) 		4 / 7 PHE B 183
VAL B 204
ARG B 146
VAL B 129
 None
 1.23A 5g0pA-5nstB:
undetectable
5g0pB-5nstB:
undetectable		 5g0pA-5nstB:
20.54
5g0pB-5nstB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5nst LIGHT CHAIN OF
ANTIBODY MGD21
HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PRO A 113
MET A 175
VAL A 115
ILE A 117
LEU B 261
 None
 1.29A 5tiwB-5nstA:
undetectable		 5tiwB-5nstA:
18.68