SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ntf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 9 VAL A 283
TYR A 516
LEU A 517
ILE A 491
LEU A 285
 None
 1.12A 1eqgA-5ntfA:
undetectable		 1eqgA-5ntfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 283
TYR A 516
LEU A 517
ILE A 491
LEU A 285
 None
 1.11A 1eqgB-5ntfA:
undetectable		 1eqgB-5ntfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 7 CYH A 320
SER A 204
PHE A 319
LEU A 340
 None
 1.04A 1qcaA-5ntfA:
undetectable		 1qcaA-5ntfA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 314
GLY A 287
LEU A 338
VAL A 212
PRO A 510
 None
 0.99A 1zq9B-5ntfA:
undetectable		 1zq9B-5ntfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		3 / 3 SER A 160
ASP A 121
CYH A 116
 None
 0.96A 2br4E-5ntfA:
undetectable		 2br4E-5ntfA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		3 / 3 THR A 148
PRO A 191
PRO A 188
 None
 0.90A 2d55C-5ntfA:
undetectable		 2d55C-5ntfA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 PHE A 508
LEU A 512
SER A 434
VAL A 396
LEU A 334
 None
 1.36A 2hc4A-5ntfA:
undetectable		 2hc4A-5ntfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 8 THR A 139
VAL A 181
PHE A  46
ALA A 130
 None
 1.15A 2ij7C-5ntfA:
undetectable		 2ij7C-5ntfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 268
VAL A 269
THR A 270
VAL A 318
 None
 0.95A 2qblA-5ntfA:
undetectable		 2qblA-5ntfA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 131
ALA A 130
THR A  83
GLY A  51
GLN A  55
 None
 1.11A 2ve3A-5ntfA:
undetectable		 2ve3A-5ntfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 255
GLY A 254
TYR A 252
GLY A 378
LEU A 377
 None
 1.21A 2y7kD-5ntfA:
undetectable		 2y7kD-5ntfA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 VAL A 155
ALA A 154
ALA A 118
GLU A 515
THR A 205
 None
 1.09A 3dl9B-5ntfA:
undetectable		 3dl9B-5ntfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 7 VAL A 269
GLN A 229
ALA A 222
ARG A 267
 None
 1.07A 3kp6B-5ntfA:
undetectable		 3kp6B-5ntfA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 217
PRO A 215
TYR A 176
ALA A 167
 None
 1.02A 3twpA-5ntfA:
2.2		 3twpA-5ntfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 217
PRO A 215
TYR A 176
ALA A 167
 None
 1.06A 3twpB-5ntfA:
2.1		 3twpB-5ntfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 217
PRO A 215
TYR A 176
ALA A 167
 None
 1.06A 3twpC-5ntfA:
2.2		 3twpC-5ntfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 5 ASN A 217
PRO A 215
TYR A 176
ALA A 167
 None
 1.04A 3twpD-5ntfA:
undetectable		 3twpD-5ntfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 11 TYR A 350
LEU A 356
VAL A 366
PHE A 477
ALA A 371
 None
None
None
None
SO4  A 601 (-4.2A)
 1.35A 4evrA-5ntfA:
2.4		 4evrA-5ntfA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 513
VAL A 493
GLY A 410
PHE A 508
THR A 409
 None
 0.98A 4mubA-5ntfA:
undetectable		 4mubA-5ntfA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 9 VAL A 212
VAL A 227
ALA A 228
VAL A 318
ALA A 316
 None
 1.15A 4oqrA-5ntfA:
undetectable		 4oqrA-5ntfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 11 ASP A 370
PHE A 304
ASP A 293
MET A 308
GLY A 295
 None
 1.27A 4qa0B-5ntfA:
2.2		 4qa0B-5ntfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 ASP A 370
PHE A 304
ASP A 293
MET A 308
GLY A 295
 None
 1.22A 4qa2A-5ntfA:
2.6		 4qa2A-5ntfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 ASP A 370
PHE A 304
ASP A 293
MET A 308
GLY A 295
 None
 1.24A 4qa2B-5ntfA:
undetectable		 4qa2B-5ntfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 307
PHE A 165
TYR A 176
ASP A 213
PRO A 215
 None
 1.30A 4rtrA-5ntfA:
2.4		 4rtrA-5ntfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 307
PHE A 165
TYR A 176
ASP A 213
PRO A 215
 None
 1.19A 4rtsA-5ntfA:
undetectable		 4rtsA-5ntfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 4 VAL A 394
ALA A 284
PHE A 486
THR A 385
 None
 1.19A 4z4fA-5ntfA:
2.3		 4z4fA-5ntfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 4 VAL A 394
ALA A 284
PHE A 486
THR A 385
 None
 1.21A 4z4hA-5ntfA:
2.2		 4z4hA-5ntfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 407
PHE A 497
ASP A 293
ARG A 374
GLU A 372
 None
None
None
SO4  A 601 (-4.0A)
SO4  A 601 (-3.2A)
 1.36A 4zjqD-5ntfA:
undetectable		 4zjqD-5ntfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 399
GLY A 295
GLY A 373
LEU A 377
GLY A 307
 None
None
SO4  A 601 (-3.0A)
None
None
 0.90A 5i73A-5ntfA:
undetectable		 5i73A-5ntfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 399
GLY A 295
GLY A 373
LEU A 377
GLY A 307
 None
None
SO4  A 601 (-3.0A)
None
None
 0.89A 5i75A-5ntfA:
undetectable		 5i75A-5ntfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 356
LEU A 358
PRO A 266
ALA A 341
LEU A 268
 None
 1.06A 5og9B-5ntfA:
undetectable		 5og9B-5ntfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 323
ALA A 325
LEU A 328
LEU A 334
 None
 0.76A 5vkqA-5ntfA:
undetectable
5vkqD-5ntfA:
undetectable		 5vkqA-5ntfA:
15.53
5vkqD-5ntfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 334
LEU A 323
ALA A 325
LEU A 328
 None
 0.76A 5vkqA-5ntfA:
undetectable
5vkqB-5ntfA:
undetectable		 5vkqA-5ntfA:
15.53
5vkqB-5ntfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 334
LEU A 323
ALA A 325
LEU A 328
 None
 0.77A 5vkqB-5ntfA:
undetectable
5vkqC-5ntfA:
undetectable		 5vkqB-5ntfA:
15.53
5vkqC-5ntfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 334
LEU A 323
ALA A 325
LEU A 328
 None
 0.79A 5vkqC-5ntfA:
undetectable
5vkqD-5ntfA:
undetectable		 5vkqC-5ntfA:
15.53
5vkqD-5ntfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		4 / 6 ARG A 374
GLY A 373
SER A 462
THR A 369
 SO4  A 601 (-4.0A)
SO4  A 601 (-3.0A)
None
None
 1.20A 5ysiA-5ntfA:
undetectable		 5ysiA-5ntfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5ntf AMINOPEPTIDASE
(Trypanosoma
cruzi) 		5 / 5 VAL A 186
THR A 184
LEU A  64
VAL A  71
LEU A  56
 None
 1.33A 6bqgA-5ntfA:
undetectable		 6bqgA-5ntfA:
9.42