SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 9 ILE A 264
GLY A 263
CYH A 358
LEU A 396
TYR A 369
 None
 1.44A 1dgmA-5nthA:
undetectable		 1dgmA-5nthA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 CYH A 331
SER A 213
PHE A 330
LEU A 359
 None
 1.10A 1qcaA-5nthA:
undetectable		 1qcaA-5nthA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 5 PHE A 347
LEU A 244
MET A 342
LEU A 207
 None
 1.26A 1skxA-5nthA:
undetectable		 1skxA-5nthA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 THR A 321
GLY A 324
GLY A 325
GLY A 300
ASP A 322
 None
None
None
None
MN  A 602 (-2.3A)
 1.16A 1wg8B-5nthA:
undetectable		 1wg8B-5nthA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 6 ALA A 363
ASN A 362
ILE A 301
ASP A 304
 None
None
None
MN  A 603 (-2.6A)
 1.04A 1yc2A-5nthA:
undetectable		 1yc2A-5nthA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 5 ALA A 363
ASN A 362
ILE A 301
ASP A 304
 None
None
None
MN  A 603 (-2.6A)
 1.04A 1yc2D-5nthA:
undetectable		 1yc2D-5nthA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 5 ALA A 363
ASN A 362
ILE A 301
ASP A 304
 None
None
None
MN  A 603 (-2.6A)
 1.06A 2h4jA-5nthA:
undetectable		 2h4jA-5nthA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 LYS A 320
TYR A 164
PRO A 224
 None
 0.97A 2j9cC-5nthA:
1.5		 2j9cC-5nthA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 THR A  17
VAL A  19
SER A  20
ARG A   7
 None
 1.04A 2v2gA-5nthA:
undetectable
2v2gB-5nthA:
undetectable		 2v2gA-5nthA:
18.89
2v2gB-5nthA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 THR A  17
VAL A  19
SER A  20
ARG A   7
 None
 1.05A 2v2gC-5nthA:
undetectable
2v2gD-5nthA:
undetectable		 2v2gC-5nthA:
18.89
2v2gD-5nthA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 10 TYR A 282
PHE A 347
ILE A 294
ASN A 352
ALA A 351
 None
 1.38A 3ay0A-5nthA:
undetectable		 3ay0A-5nthA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 VAL A 278
ILE A 264
GLY A 263
ARG A 257
 None
 0.82A 3bjwH-5nthA:
undetectable		 3bjwH-5nthA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 6 ILE A 264
TYR A 401
ILE A 251
HIS A 276
 None
 1.17A 3eteA-5nthA:
2.5
3eteE-5nthA:
2.3		 3eteA-5nthA:
23.57
3eteE-5nthA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 5 ILE A 264
TYR A 401
ILE A 251
HIS A 276
 None
 1.17A 3eteB-5nthA:
1.6
3eteC-5nthA:
2.3		 3eteB-5nthA:
23.57
3eteC-5nthA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 ILE A 251
HIS A 276
ILE A 264
TYR A 401
 None
 1.17A 3eteD-5nthA:
2.4
3eteF-5nthA:
1.6		 3eteD-5nthA:
23.57
3eteF-5nthA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		6 / 12 ALA A 160
LEU A 182
ALA A 126
VAL A 529
ILE A 210
CYH A 211
 None
 1.31A 3h0aA-5nthA:
undetectable		 3h0aA-5nthA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 9 MET A 417
VAL A 329
ILE A 294
LEU A 536
ILE A 415
 None
 1.29A 3jw3B-5nthA:
undetectable		 3jw3B-5nthA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 LEU A  49
VAL A  51
SER A 122
CYH A 129
VAL A 184
 None
 1.27A 3m7rA-5nthA:
undetectable		 3m7rA-5nthA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 9 VAL A 278
LEU A 220
ILE A 236
ALA A 237
ALA A 327
 None
 1.08A 3mdvA-5nthA:
undetectable		 3mdvA-5nthA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 GLY A 300
GLY A 298
MET A 377
VAL A 267
ALA A 266
 None
 1.10A 3t7vA-5nthA:
undetectable		 3t7vA-5nthA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 GLU A 406
TYR A 401
SER A 502
 None
 1.00A 4at0A-5nthA:
undetectable		 4at0A-5nthA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 ASP A 513
GLY A 422
GLY A 489
SER A 490
HIS A 315
 None
BB2  A 604 (-3.8A)
None
None
BB2  A 604 (-3.5A)
 1.17A 4blvB-5nthA:
undetectable		 4blvB-5nthA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 9 TYR A 369
GLY A 268
ILE A 264
GLY A 263
ILE A 394
 None
 1.00A 4eatB-5nthA:
3.0		 4eatB-5nthA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 LEU A 456
ASP A 455
ALA A 153
SER A 122
THR A 525
 None
 1.30A 4iarA-5nthA:
undetectable		 4iarA-5nthA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 8 THR A  87
ALA A  89
THR A  98
VAL A 100
 None
 0.79A 4ik7B-5nthA:
undetectable		 4ik7B-5nthA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 GLN A  24
ARG A   7
VAL A 232
ILE A 236
CYH A  26
 None
 1.23A 4k38A-5nthA:
undetectable
4k38D-5nthA:
undetectable		 4k38A-5nthA:
22.06
4k38D-5nthA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 LYS A 311
LYS A 299
ALA A 390
 BB2  A 604 ( 2.6A)
MN  A 602 ( 2.0A)
BCT  A 601 (-3.6A)
 1.14A 4ot2A-5nthA:
1.0		 4ot2A-5nthA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 5 HIS A  47
VAL A  48
GLU A  99
VAL A 132
 None
 1.23A 4p6vB-5nthA:
1.0
4p6vE-5nthA:
0.9		 4p6vB-5nthA:
22.12
4p6vE-5nthA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 GLU A 465
SER A 438
GLU A 498
THR A 404
 None
 1.24A 4uacA-5nthA:
undetectable		 4uacA-5nthA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 6 VAL A  51
LEU A 138
ALA A 124
ALA A 155
 None
 0.71A 4zf8A-5nthA:
undetectable		 4zf8A-5nthA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 VAL A 152
GLU A 149
LEU A  62
ALA A 144
SER A 148
 None
 1.32A 5hnzB-5nthA:
3.6		 5hnzB-5nthA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 ILE A 394
TYR A 369
GLY A 493
PHE A 496
GLY A 397
 None
 1.24A 5i75A-5nthA:
undetectable		 5i75A-5nthA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 VAL A 529
GLN A 215
CYH A 217
 None
 0.70A 5icxA-5nthA:
undetectable
5icxE-5nthA:
undetectable		 5icxA-5nthA:
17.16
5icxE-5nthA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 VAL A 529
GLN A 215
CYH A 217
 None
 0.90A 5icxC-5nthA:
undetectable
5icxF-5nthA:
undetectable		 5icxC-5nthA:
17.16
5icxF-5nthA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 ASP A 119
VAL A 152
ALA A 124
VAL A 142
GLY A  82
 None
 0.93A 5igjA-5nthA:
undetectable		 5igjA-5nthA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 VAL A 152
GLU A 149
LEU A  62
ALA A 144
SER A 148
 None
 1.36A 5nd2B-5nthA:
undetectable		 5nd2B-5nthA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 5 VAL A 510
ASP A 439
PRO A 508
ALA A 437
 None
 1.12A 5otrA-5nthA:
undetectable		 5otrA-5nthA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 9 VAL A 512
MET A 514
CYH A 457
GLY A 450
MET A 446
 None
 1.40A 5w5vA-5nthA:
undetectable		 5w5vA-5nthA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 LYS A 320
ASN A 318
SER A 519
 None
 0.89A 5yw0A-5nthA:
undetectable		 5yw0A-5nthA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		4 / 7 HIS A 432
ARG A 117
ASP A 119
GLU A 123
 None
 1.27A 6mn4F-5nthA:
undetectable		 6mn4F-5nthA:
20.40