SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ntu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CLA_A_CLMA221_0 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	5ntu	GROWTH/DIFFERENTIATI ON FACTOR 8 (Homo sapiens)	5 / 11	THR A 240 ALA A 238 LEU A 160 VAL A 208 ILE A 225	EDO A 403 (-3.7A) EDO A 403 (-4.9A) None None None	1.48A	4claA-5ntuA: undetectable	4claA-5ntuA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5ntu	GROWTH/DIFFERENTIATI ON FACTOR 8 (Homo sapiens)	5 / 11	VAL A 171 SER A 205 THR A 240 PHE A 252 LEU A 156	None EDO A 405 (-3.4A) EDO A 403 (-3.7A) None None	1.26A	4kyaA-5ntuA: undetectable	4kyaA-5ntuA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_E_FOLE703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5ntu	GROWTH/DIFFERENTIATI ON FACTOR 8 (Homo sapiens)	5 / 11	VAL A 171 SER A 205 THR A 240 PHE A 252 LEU A 156	None EDO A 405 (-3.4A) EDO A 403 (-3.7A) None None	1.23A	4kyaE-5ntuA: undetectable	4kyaE-5ntuA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_G_FOLG703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5ntu	GROWTH/DIFFERENTIATI ON FACTOR 8 (Homo sapiens)	5 / 11	VAL A 171 SER A 205 THR A 240 PHE A 252 LEU A 156	None EDO A 405 (-3.4A) EDO A 403 (-3.7A) None None	1.21A	4kyaG-5ntuA: undetectable	4kyaG-5ntuA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4CLA_A_CLMA221_0","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","5ntu","GROWTH\/DIFFERENTIATION FACTOR 8","Homo sapiens",5,"THR A 240;ALA A 238;LEU A 160;VAL A 208;ILE A 225","EDO A 403 (-3.7A);EDO A 403 (-4.9A);None;None;None","1.48A","4claA-5ntuA:undetectable","4claA-5ntuA:undetectable"],["4KYA_A_FOLA703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5ntu","GROWTH\/DIFFERENTIATION FACTOR 8","Homo sapiens",5,"VAL A 171;SER A 205;THR A 240;PHE A 252;LEU A 156","None;EDO A 405 (-3.4A);EDO A 403 (-3.7A);None;None","1.26A","4kyaA-5ntuA:undetectable","4kyaA-5ntuA:undetectable"],["4KYA_E_FOLE703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5ntu","GROWTH\/DIFFERENTIATION FACTOR 8","Homo sapiens",5,"VAL A 171;SER A 205;THR A 240;PHE A 252;LEU A 156","None;EDO A 405 (-3.4A);EDO A 403 (-3.7A);None;None","1.23A","4kyaE-5ntuA:undetectable","4kyaE-5ntuA:undetectable"],["4KYA_G_FOLG703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5ntu","GROWTH\/DIFFERENTIATION FACTOR 8","Homo sapiens",5,"VAL A 171;SER A 205;THR A 240;PHE A 252;LEU A 156","None;EDO A 405 (-3.4A);EDO A 403 (-3.7A);None;None","1.21A","4kyaG-5ntuA:undetectable","4kyaG-5ntuA:undetectable"]]