SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.02A 1cqeA-5nugA:
undetectable		 1cqeA-5nugA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.02A 1cqeB-5nugA:
undetectable		 1cqeB-5nugA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LEU A2585
THR A2604
ALA A2608
LEU A2612
 None
 1.27A 1etb2-5nugA:
undetectable		 1etb2-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 PHE A4125
PHE A4147
HIS A4054
VAL A4031
 None
 0.79A 1fslB-5nugA:
undetectable		 1fslB-5nugA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 10 PHE A2606
LEU A2609
ALA A2608
PHE A2662
PHE A2708
 None
 1.00A 1g5yC-5nugA:
undetectable		 1g5yC-5nugA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 LEU A1547
PHE A1551
LEU A1638
ILE A1571
ARG A1623
 None
 1.12A 1hrkB-5nugA:
undetectable		 1hrkB-5nugA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 GLY A1924
LEU A1923
GLY A1869
ARG A1925
 None
 0.76A 1j7kA-5nugA:
undetectable		 1j7kA-5nugA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 10 GLY A1549
LEU A1486
TYR A1480
LYS A1645
GLY A1642
 None
 1.19A 1kvlA-5nugA:
undetectable		 1kvlA-5nugA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4041
SER A4045
PHE A4147
HIS A4054
TYR A4049
 None
 1.35A 1kw0A-5nugA:
undetectable		 1kw0A-5nugA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 ALA A4005
HIS A4006
VAL A4009
 None
 0.40A 1lqtB-5nugA:
undetectable		 1lqtB-5nugA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 ALA A4005
HIS A4006
VAL A4009
 None
 0.41A 1lquB-5nugA:
undetectable		 1lquB-5nugA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LEU A3011
VAL A2950
ILE A2993
ARG A2831
 None
 1.04A 1opjB-5nugA:
undetectable		 1opjB-5nugA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 10 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.95A 1pxxA-5nugA:
undetectable		 1pxxA-5nugA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 1pxxB-5nugA:
undetectable		 1pxxB-5nugA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 1pxxC-5nugA:
undetectable		 1pxxC-5nugA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 10 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.95A 1pxxD-5nugA:
undetectable		 1pxxD-5nugA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 LEU A4585
LEU A4563
VAL A4640
LEU A4607
VAL A4545
 None
 0.74A 1sn5B-5nugA:
undetectable
1sn5D-5nugA:
undetectable		 1sn5B-5nugA:
2.50
1sn5D-5nugA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 LEU A4607
VAL A4545
LEU A4585
LEU A4563
VAL A4640
 None
 0.72A 1sn5B-5nugA:
undetectable
1sn5D-5nugA:
undetectable		 1sn5B-5nugA:
2.50
1sn5D-5nugA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 LYS A1775
LEU A1778
LEU A1825
SER A1824
 None
 1.37A 1tt6A-5nugA:
undetectable		 1tt6A-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 LYS A1775
LEU A1778
LEU A1825
SER A1824
 None
 1.38A 1tz8D-5nugA:
undetectable		 1tz8D-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 LEU A2001
LEU A2028
VAL A1971
PHE A1945
ILE A2014
 None
 1.46A 1uobA-5nugA:
undetectable		 1uobA-5nugA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 VAL A1785
VAL A1816
TRP A1758
 None
 0.98A 1w5uA-5nugA:
undetectable
1w5uB-5nugA:
undetectable		 1w5uA-5nugA:
0.74
1w5uB-5nugA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 VAL A1821
VAL A1816
TRP A1758
 None
 0.92A 1w5uC-5nugA:
undetectable
1w5uD-5nugA:
undetectable		 1w5uC-5nugA:
0.74
1w5uD-5nugA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 PHE A3619
VAL A3635
LEU A3679
PHE A3583
LEU A3645
 None
 1.32A 1wrkA-5nugA:
undetectable
1wrkB-5nugA:
undetectable		 1wrkA-5nugA:
1.77
1wrkB-5nugA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 LEU A3679
PHE A3614
LEU A3649
SER A2997
 None
 0.95A 1wrlE-5nugA:
undetectable
1wrlF-5nugA:
undetectable		 1wrlE-5nugA:
1.77
1wrlF-5nugA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 THR A2785
GLU A2842
HIS A2791
 None
 0.90A 1xwfA-5nugA:
undetectable		 1xwfA-5nugA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 TRP A4185
ARG A4271
PHE A4268
 None
 1.42A 1zeaH-5nugA:
undetectable
1zeaL-5nugA:
undetectable		 1zeaH-5nugA:
4.35
1zeaL-5nugA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 PHE A1844
GLU A1814
GLN A1881
TYR A1889
 None
 1.42A 2aoxA-5nugA:
undetectable		 2aoxA-5nugA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.08A 2aylB-5nugA:
undetectable		 2aylB-5nugA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		6 / 12 PHE A3868
PHE A3864
ALA A3872
ILE A3811
ILE A3890
LEU A3818
 None
 1.44A 2bjfA-5nugA:
undetectable		 2bjfA-5nugA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 PHE A4145
VAL A4055
THR A4039
ARG A4123
GLY A4032
 None
 1.07A 2cbrA-5nugA:
undetectable		 2cbrA-5nugA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LEU A1615
TYR A1618
ILE A1557
GLY A1642
 None
 0.92A 2du8A-5nugA:
undetectable		 2du8A-5nugA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LEU A1615
TYR A1618
ILE A1557
GLY A1642
 None
 0.88A 2du8B-5nugA:
undetectable		 2du8B-5nugA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 PHE A2280
GLY A2305
ASP A2277
LEU A2325
VAL A2307
 None
 1.08A 2hmyB-5nugA:
undetectable		 2hmyB-5nugA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 ARG A3655
GLY A3658
VAL A3653
ILE A3662
VAL A3648
 None
 1.27A 2nnhB-5nugA:
undetectable		 2nnhB-5nugA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LEU A3892
MET A4343
MET A4346
LEU A3909
 None
 1.43A 2oz7A-5nugA:
undetectable		 2oz7A-5nugA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 VAL A1821
THR A1822
VAL A1785
TRP A1758
 None
 1.03A 2p2fA-5nugA:
undetectable		 2p2fA-5nugA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 PHE A1960
PHE A1938
PHE A1945
ILE A4069
 None
 1.36A 2v0mD-5nugA:
undetectable		 2v0mD-5nugA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 LEU A4042
PRO A4040
LEU A4124
ALA A4141
LEU A4113
 None
 1.04A 2vcvD-5nugA:
undetectable		 2vcvD-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 LEU A4042
PRO A4040
LEU A4124
ALA A4141
LEU A4113
 None
 1.04A 2vcvE-5nugA:
undetectable		 2vcvE-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 TYR A3176
PHE A3179
LEU A3536
LEU A3509
ALA A3512
 None
 1.30A 2vcvE-5nugA:
undetectable		 2vcvE-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 LEU A4042
PRO A4040
LEU A4124
ALA A4141
LEU A4113
 None
 1.00A 2vcvH-5nugA:
undetectable		 2vcvH-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 SER A4214
THR A4221
PHE A1836
 None
 0.77A 2x91A-5nugA:
undetectable		 2x91A-5nugA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 LEU A2758
ARG A2757
ILE A2759
 None
 0.63A 2xn5B-5nugA:
undetectable		 2xn5B-5nugA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 SER A1625
ASN A1699
LEU A1619
ILE A1641
SER A1554
 None
 1.41A 2xrlA-5nugA:
undetectable		 2xrlA-5nugA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 ASP A2372
PHE A2375
LEU A2379
 None
 0.21A 2zi9A-5nugA:
undetectable		 2zi9A-5nugA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 PRO A2527
GLU A2538
TYR A2537
 None
 0.71A 2zmbA-5nugA:
undetectable		 2zmbA-5nugA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 SER A4045
GLU A4206
ASP A4050
 None
 0.84A 2zthA-5nugA:
undetectable		 2zthA-5nugA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 PHE A4624
THR A4588
LEU A4590
VAL A4609
 None
 0.95A 2zwtA-5nugA:
undetectable		 2zwtA-5nugA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 PHE A3701
PHE A3698
GLY A3518
ILE A3589
PHE A3688
 None
 1.22A 2zznB-5nugA:
undetectable		 2zznB-5nugA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ILE A2534
MET A2461
LEU A2499
ILE A2498
THR A2522
 None
 1.12A 3a51D-5nugA:
undetectable		 3a51D-5nugA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 LEU A3536
GLN A3538
PHE A3543
LEU A3509
 None
 1.02A 3ag2C-5nugA:
undetectable		 3ag2C-5nugA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 8 LEU A3536
GLN A3538
PHE A3543
LEU A3509
PHE A3529
 None
 1.44A 3ag4C-5nugA:
undetectable
3ag4J-5nugA:
undetectable		 3ag4C-5nugA:
4.40
3ag4J-5nugA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 ASP A2995
LEU A2935
LEU A3012
HIS A2932
 ADP  A4805 ( 4.6A)
None
None
None
 1.17A 3bj8C-5nugA:
undetectable
3bj8D-5nugA:
undetectable		 3bj8C-5nugA:
3.31
3bj8D-5nugA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 11 ALA A1862
PHE A1836
MET A1842
GLN A1881
GLN A4249
 None
 1.38A 3bszF-5nugA:
undetectable		 3bszF-5nugA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 ILE A3811
GLN A3709
ILE A3835
LEU A3802
 None
 1.24A 3dzyD-5nugA:
undetectable		 3dzyD-5nugA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 VAL A2649
LYS A2702
HIS A2588
 None
 0.89A 3elzA-5nugA:
undetectable		 3elzA-5nugA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A3619
LEU A3664
VAL A3648
ASP A3642
 None
 1.12A 3fwgA-5nugA:
undetectable		 3fwgA-5nugA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LYS A3225
GLN A3227
LEU A3229
GLU A3230
 None
 0.87A 3h5gA-5nugA:
undetectable
3h5gC-5nugA:
undetectable		 3h5gA-5nugA:
0.60
3h5gC-5nugA:
0.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ALA A4188
LEU A4212
SER A4162
ILE A4164
ARG A4168
 None
 1.28A 3ia4B-5nugA:
undetectable		 3ia4B-5nugA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 ASN A2667
ASP A2717
ARG A2511
 None
 0.80A 3k13A-5nugA:
undetectable		 3k13A-5nugA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 SER A2162
PHE A2165
ILE A2138
CYH A2142
 None
 0.68A 3ko0B-5nugA:
undetectable		 3ko0B-5nugA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 SER A2162
PHE A2165
ILE A2138
CYH A2142
 None
 0.77A 3ko0S-5nugA:
undetectable		 3ko0S-5nugA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 VAL A1821
VAL A1816
TRP A1758
 None
 0.91A 3l8lC-5nugA:
undetectable
3l8lD-5nugA:
undetectable		 3l8lC-5nugA:
0.74
3l8lD-5nugA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ALA A4102
LEU A4109
LEU A4106
ALA A4080
ILE A4071
 None
 1.42A 3lbdA-5nugA:
undetectable		 3lbdA-5nugA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 PRO A3568
SER A3707
ASN A3576
 None
 0.89A 3lslG-5nugA:
undetectable		 3lslG-5nugA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.02A 3n8wA-5nugA:
undetectable		 3n8wA-5nugA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 11 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 3n8yA-5nugA:
undetectable		 3n8yA-5nugA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.04A 3n8zA-5nugA:
undetectable		 3n8zA-5nugA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.04A 3n8zB-5nugA:
undetectable		 3n8zB-5nugA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 ALA A3884
ILE A3881
HIS A4006
HIS A3877
 None
 1.12A 3nneG-5nugA:
undetectable		 3nneG-5nugA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 ILE A3766
ALA A3477
LEU A3478
LEU A3753
ALA A3752
 None
 1.10A 3ozvB-5nugA:
undetectable		 3ozvB-5nugA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 11 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 3pghB-5nugA:
undetectable		 3pghB-5nugA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 3pghD-5nugA:
undetectable		 3pghD-5nugA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 GLN A3667
ASP A3666
ARG A3620
GLU A3624
 None
 1.31A 3r4xA-5nugA:
undetectable		 3r4xA-5nugA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 GLN A3667
ASP A3666
ARG A3620
GLU A3624
 None
 1.43A 3r55A-5nugA:
undetectable		 3r55A-5nugA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 MET A2755
LEU A2769
ASN A2752
MET A2773
 None
 0.67A 3rfmA-5nugA:
undetectable		 3rfmA-5nugA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 11 THR A1910
GLY A1909
ARG A2358
THR A1913
ASP A2320
 None
ADP  A4801 (-3.8A)
ADP  A4801 (-2.9A)
ADP  A4801 (-3.8A)
ADP  A4801 (-3.3A)
 1.16A 3t8nD-5nugA:
undetectable
3t8nF-5nugA:
undetectable		 3t8nD-5nugA:
2.56
3t8nF-5nugA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 11 THR A1910
GLY A1909
THR A1913
PRO A1904
ASP A2320
 None
ADP  A4801 (-3.8A)
ADP  A4801 (-3.8A)
None
ADP  A4801 (-3.3A)
 1.36A 3t8nD-5nugA:
undetectable
3t8nF-5nugA:
undetectable		 3t8nD-5nugA:
2.56
3t8nF-5nugA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 ARG A1819
LEU A1782
VAL A1785
ASP A1820
 None
 1.17A 3ufnA-5nugA:
undetectable
3ufnB-5nugA:
undetectable		 3ufnA-5nugA:
2.09
3ufnB-5nugA:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 LYS A1917
ARG A1679
LEU A2324
 None
 1.06A 3v4tE-5nugA:
undetectable		 3v4tE-5nugA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 THR A2421
TYR A2426
ARG A2383
LEU A2382
 None
 1.12A 3wipG-5nugA:
undetectable
3wipH-5nugA:
undetectable		 3wipG-5nugA:
4.18
3wipH-5nugA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 ARG A2383
LEU A2382
THR A2421
TYR A2426
 None
 1.12A 3wipF-5nugA:
undetectable
3wipJ-5nugA:
undetectable		 3wipF-5nugA:
4.18
3wipJ-5nugA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A3619
LEU A3664
VAL A3648
ASP A3642
 None
 1.12A 3wrhE-5nugA:
undetectable		 3wrhE-5nugA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A3619
LEU A3664
VAL A3648
ASP A3642
 None
 1.13A 3wrjE-5nugA:
undetectable		 3wrjE-5nugA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 VAL A1582
LEU A1475
ILE A1487
VAL A1597
 None
 0.94A 4a9kA-5nugA:
undetectable		 4a9kA-5nugA:
2.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 ARG A3007
ASP A2636
GLU A3048
LEU A3020
 None
 1.32A 4ax8A-5nugA:
undetectable		 4ax8A-5nugA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 TRP A4240
LEU A4179
LEU A4223
THR A4226
 None
 1.15A 4bboD-5nugA:
undetectable		 4bboD-5nugA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 HIS A1810
SER A2056
GLU A1814
ASP A1886
 None
 1.36A 4blvA-5nugA:
undetectable		 4blvA-5nugA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A2592
ILE A2666
ASN A2667
PHE A2727
HIS A2725
 None
 1.27A 4c49D-5nugA:
undetectable		 4c49D-5nugA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 TRP A1741
TYR A1738
THR A1788
LEU A1815
LEU A1811
 None
 1.43A 4c9kA-5nugA:
undetectable		 4c9kA-5nugA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 9 TRP A1741
TYR A1738
THR A1788
LEU A1815
LEU A1811
 None
 1.39A 4c9pA-5nugA:
undetectable		 4c9pA-5nugA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.05A 4coxC-5nugA:
undetectable		 4coxC-5nugA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 LEU A1716
SER A1720
THR A1740
ASP A1743
 None
 1.10A 4drjB-5nugA:
undetectable		 4drjB-5nugA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A3619
LEU A3664
VAL A3648
ASP A3642
 None
 1.07A 4ek1A-5nugA:
undetectable		 4ek1A-5nugA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 ILE A4164
PRO A4297
VAL A4309
TRP A4308
 None
 1.19A 4f4dB-5nugA:
undetectable		 4f4dB-5nugA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 ILE A4294
GLY A4322
ASN A4325
GLU A4637
 None
 0.96A 4fgjA-5nugA:
undetectable
4fgjB-5nugA:
undetectable		 4fgjA-5nugA:
4.40
4fgjB-5nugA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 GLY A2201
GLY A2200
MET A2373
GLU A2205
 None
None
ATP  A4802 (-3.4A)
None
 1.31A 4fglC-5nugA:
undetectable		 4fglC-5nugA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 GLU A4206
TYR A4205
GLY A4254
ARG A4255
 None
 0.93A 4fgzA-5nugA:
undetectable		 4fgzA-5nugA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A3619
LEU A3664
VAL A3648
ASP A3642
 None
 1.12A 4g3rA-5nugA:
undetectable		 4g3rA-5nugA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 THR A1552
ASN A1643
GLN A1651
LEU A1650
 None
 1.11A 4ib4A-5nugA:
undetectable		 4ib4A-5nugA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 ILE A2254
HIS A2218
LEU A2335
LEU A2284
 None
 0.91A 4l1wA-5nugA:
undetectable		 4l1wA-5nugA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A3619
LEU A3664
VAL A3648
ASP A3642
 None
 1.10A 4l4cA-5nugA:
undetectable		 4l4cA-5nugA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 PHE A3675
LEU A3664
VAL A3635
ILE A3677
 None
 0.97A 4l4cB-5nugA:
undetectable		 4l4cB-5nugA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 TRP A1544
GLN A1566
THR A1573
 None
 0.85A 4m2xA-5nugA:
undetectable		 4m2xA-5nugA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 CYH A3712
LEU A3829
VAL A3703
LEU A3863
LEU A3840
 None
 1.08A 4o8fB-5nugA:
undetectable		 4o8fB-5nugA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 GLN A3667
ASP A3666
ARG A3620
GLU A3624
 None
 1.48A 4qyqC-5nugA:
undetectable		 4qyqC-5nugA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 GLY A4104
ILE A4069
ALA A4070
GLY A4072
GLU A1965
 None
 1.02A 4r29D-5nugA:
undetectable		 4r29D-5nugA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.01A 4rrwA-5nugA:
undetectable		 4rrwA-5nugA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.02A 4rrwB-5nugA:
undetectable		 4rrwB-5nugA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.00A 4rrwC-5nugA:
undetectable		 4rrwC-5nugA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.00A 4rrxA-5nugA:
undetectable		 4rrxA-5nugA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.00A 4rrxB-5nugA:
undetectable		 4rrxB-5nugA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.01A 4rrzA-5nugA:
undetectable		 4rrzA-5nugA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.02A 4rrzB-5nugA:
undetectable		 4rrzB-5nugA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.00A 4rrzC-5nugA:
undetectable		 4rrzC-5nugA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 ASP A2717
LYS A4443
THR A2716
THR A4445
 None
 1.46A 4w5qA-5nugA:
undetectable		 4w5qA-5nugA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 ASP A2717
LYS A4443
THR A2716
THR A4445
 None
 1.48A 4w5tA-5nugA:
undetectable		 4w5tA-5nugA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 10 LEU A3679
ASP A3642
TYR A3641
SER A3640
ILE A3677
 None
 0.89A 4xj7C-5nugA:
undetectable
4xj7D-5nugA:
undetectable		 4xj7C-5nugA:
4.62
4xj7D-5nugA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 VAL A2701
THR A2699
ARG A2694
 None
 0.69A 5b2sB-5nugA:
undetectable		 5b2sB-5nugA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 VAL A2701
THR A2699
ARG A2694
 None
 0.74A 5b2tB-5nugA:
undetectable		 5b2tB-5nugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 SER A2780
TYR A2794
PHE A2784
HIS A2791
 None
 1.37A 5dlvB-5nugA:
undetectable		 5dlvB-5nugA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 7 VAL A4642
LEU A4585
VAL A4543
THR A4588
 None
 1.02A 5e4dA-5nugA:
undetectable
5e4dB-5nugA:
undetectable		 5e4dA-5nugA:
3.68
5e4dB-5nugA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 GLU A2331
PHE A1551
ILE A1557
TYR A1618
GLY A1549
 None
 1.34A 5esgA-5nugA:
undetectable		 5esgA-5nugA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 CYH A2454
LEU A2502
LEU A2437
ALA A2436
 None
 1.00A 5hpuA-5nugA:
undetectable
5hpuB-5nugA:
undetectable		 5hpuA-5nugA:
0.56
5hpuB-5nugA:
0.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 GLN A3667
ASP A3666
ARG A3620
GLU A3624
 None
 1.48A 5hpwC-5nugA:
undetectable		 5hpwC-5nugA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 TYR A3586
LEU A3627
LEU A3623
THR A3612
 None
 1.13A 5hs6A-5nugA:
undetectable		 5hs6A-5nugA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A2701
PRO A2652
ALA A2651
VAL A2649
LEU A2661
 None
 1.16A 5hv1A-5nugA:
undetectable		 5hv1A-5nugA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 10 ILE A2990
MET A2994
LEU A3062
VAL A3017
LEU A3020
 None
 1.07A 5ienB-5nugA:
undetectable		 5ienB-5nugA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.05A 5ikqA-5nugA:
undetectable		 5ikqA-5nugA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.03A 5ikqB-5nugA:
undetectable		 5ikqB-5nugA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.07A 5ikrB-5nugA:
undetectable		 5ikrB-5nugA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ILE A2016
LEU A2028
SER A4210
ARG A2037
GLY A1902
 None
 1.31A 5il1A-5nugA:
undetectable		 5il1A-5nugA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.03A 5kirA-5nugA:
undetectable		 5kirA-5nugA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 LEU A2723
ARG A2684
ILE A2680
PHE A2727
 None
ATP  A4802 (-3.7A)
None
None
 1.18A 5kirB-5nugA:
undetectable		 5kirB-5nugA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 LYS A1775
LEU A1778
LEU A1825
SER A1824
 None
 1.21A 5l4iB-5nugA:
undetectable		 5l4iB-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ARG A1710
HIS A1810
GLU A1682
GLY A1874
GLY A1660
 None
 1.18A 5l6eA-5nugA:
undetectable		 5l6eA-5nugA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ILE A2680
ILE A2666
VAL A2679
THR A2626
GLU A3006
 None
 1.06A 5lg3E-5nugA:
undetectable		 5lg3E-5nugA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ILE A2680
ILE A2666
VAL A2679
THR A2626
GLU A3006
 None
 1.07A 5lg3J-5nugA:
undetectable		 5lg3J-5nugA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ALA A4641
LEU A4643
LEU A4563
LEU A4511
LEU A4618
 None
 1.04A 5toaA-5nugA:
undetectable		 5toaA-5nugA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 GLN A3826
PHE A3832
ASP A3834
LEU A4139
PRO A4040
 None
 1.48A 5uacC-5nugA:
undetectable		 5uacC-5nugA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 5 THR A3704
GLU A3575
THR A3550
LEU A3567
 None
 1.27A 5utuH-5nugA:
undetectable		 5utuH-5nugA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ARG A2576
VAL A2524
LEU A2432
GLY A2515
ILE A2534
 None
 0.98A 5vooA-5nugA:
undetectable		 5vooA-5nugA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 LEU A1896
ALA A1895
THR A1913
ILE A2014
ALA A2013
 None
None
ADP  A4801 (-3.8A)
None
None
 1.24A 5xiwD-5nugA:
undetectable		 5xiwD-5nugA:
1.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 GLU A2344
HIS A2689
PHE A2682
LEU A2632
 MG  A4803 ( 3.1A)
None
None
None
 1.02A 5y2tB-5nugA:
undetectable		 5y2tB-5nugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 SER A3002
ALA A3080
ALA A2625
SER A2624
 None
 0.96A 6bocA-5nugA:
undetectable
6bocB-5nugA:
undetectable
6bocC-5nugA:
undetectable
6bocD-5nugA:
undetectable		 6bocA-5nugA:
0.62
6bocB-5nugA:
0.62
6bocC-5nugA:
0.62
6bocD-5nugA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		5 / 12 ALA A3512
THR A3153
LEU A3154
ALA A3157
TYR A3516
 None
 1.07A 6djzC-5nugA:
undetectable		 6djzC-5nugA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A2972
VAL A3064
LEU A2980
LEU A2976
 None
 1.02A 6e43A-5nugA:
undetectable		 6e43A-5nugA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 PHE A2972
VAL A3064
LEU A2980
LEU A2976
 None
 1.01A 6e43C-5nugA:
undetectable		 6e43C-5nugA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 HIS A4100
HIS A4054
ASP A2030
GLU A4206
 None
 1.26A 6mn4B-5nugA:
undetectable		 6mn4B-5nugA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 8 HIS A4100
HIS A4054
ASP A2030
GLU A4206
 None
 1.19A 6mn4D-5nugA:
undetectable		 6mn4D-5nugA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 6 THR A2326
LEU A2324
THR A2281
LEU A2319
 None
 1.18A 6mvxA-5nugA:
undetectable
6mvxB-5nugA:
undetectable
6mvxC-5nugA:
undetectable		 6mvxA-5nugA:
4.89
6mvxB-5nugA:
4.89
6mvxC-5nugA:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		3 / 3 ASP A4050
SER A1969
SER A1972
 None
 0.78A 6mxtA-5nugA:
undetectable		 6mxtA-5nugA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens) 		4 / 4 HIS A4187
LEU A4321
TYR A4196
GLY A4152
 None
 1.39A 6n91B-5nugA:
undetectable		 6n91B-5nugA:
1.64