SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5nus P34
(Chaetomium
thermophilum) 		5 / 10 PHE A  62
ALA A  61
ASN A  57
LEU A 267
ILE A  54
 None
 1.25A 1claA-5nusA:
undetectable		 1claA-5nusA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5nus P34
(Chaetomium
thermophilum) 		5 / 11 SER A 242
LEU A 246
THR A 244
MET A 221
THR A 220
 None
 1.22A 1pkvA-5nusA:
undetectable
1pkvB-5nusA:
undetectable		 1pkvA-5nusA:
12.46
1pkvB-5nusA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5nus P34
(Chaetomium
thermophilum) 		5 / 11 ALA A 238
PRO A 263
ILE A 206
ASP A  30
PHE A 257
 None
 1.28A 2admA-5nusA:
undetectable		 2admA-5nusA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5nus P34
(Chaetomium
thermophilum) 		5 / 10 ALA A  48
LEU A 205
LEU A 237
LEU A 266
ARG A  25
 None
 1.30A 2ceoB-5nusA:
undetectable		 2ceoB-5nusA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5nus P34
(Chaetomium
thermophilum) 		5 / 12 MET A 127
PRO A  33
LEU A 148
ALA A 149
THR A  26
 None
 1.23A 2jjpA-5nusA:
undetectable		 2jjpA-5nusA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5nus P34
(Chaetomium
thermophilum) 		5 / 11 GLY A 199
ILE A 153
LEU A  24
SER A  23
ALA A 202
 None
 0.97A 3dcmX-5nusA:
3.5		 3dcmX-5nusA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5nus P34
(Chaetomium
thermophilum) 		5 / 12 ALA A 157
ALA A 233
ILE A 232
ASN A  66
GLN A  67
 None
 1.12A 4r38B-5nusA:
undetectable		 4r38B-5nusA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5nus P34
(Chaetomium
thermophilum) 		5 / 12 ALA A 157
ALA A 233
ILE A 232
ASN A  66
GLN A  67
 None
 1.11A 4r38C-5nusA:
undetectable		 4r38C-5nusA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5nus P34
(Chaetomium
thermophilum) 		5 / 12 ALA A 157
ALA A 233
ILE A 232
ASN A  66
GLN A  67
 None
 1.12A 4r38D-5nusA:
undetectable		 4r38D-5nusA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5nus P34
(Chaetomium
thermophilum) 		5 / 12 ALA A 157
ALA A 233
ILE A 232
ASN A  66
GLN A  67
 None
 1.12A 4r3aA-5nusA:
undetectable		 4r3aA-5nusA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5nus P34
(Chaetomium
thermophilum) 		5 / 12 LEU A 239
LEU A 270
ASN A  51
ILE A 258
ALA A 260
 None
 1.32A 5xiwD-5nusA:
4.3		 5xiwD-5nusA:
12.87