SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 5 HIS A 172
SER A 184
LEU A 186
GLY A 261
 FMN  A1001 (-3.8A)
None
None
None
 0.92A 1a4lB-5nuxA:
7.6		 1a4lB-5nuxA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 7 GLU A 170
LEU A 171
VAL A 212
LEU A 162
 None
 0.92A 1hk3A-5nuxA:
undetectable		 1hk3A-5nuxA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 5 HIS A  79
ARG A 160
ILE A  90
HIS A  39
 None
 1.47A 1osvB-5nuxA:
undetectable		 1osvB-5nuxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 ARG A 213
PHE A 223
LEU A  53
LEU A  13
LEU A 220
 None
 0.99A 1p33A-5nuxA:
undetectable		 1p33A-5nuxA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 LEU A  80
LEU A  83
LEU A  86
ALA A  87
LEU A 162
 None
 1.05A 1ya3C-5nuxA:
undetectable		 1ya3C-5nuxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 PHE A 223
GLY A 292
LEU A 306
LEU A  53
LEU A   4
 None
 0.97A 1ya4B-5nuxA:
undetectable		 1ya4B-5nuxA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 7 ARG A  89
ALA A  47
PRO A  97
ALA A  95
 None
 1.08A 2ejfA-5nuxA:
undetectable		 2ejfA-5nuxA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 THR A 110
THR A  59
ALA A  58
ALA A 104
HIS A 103
 None
None
FMN  A1001 (-3.3A)
None
None
 0.89A 2gluB-5nuxA:
undetectable		 2gluB-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 LEU A  19
ASN A  17
LEU A   8
LEU A 255
LEU A  55
 None
 1.26A 2oaxB-5nuxA:
undetectable		 2oaxB-5nuxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 LEU A  19
ASN A  17
LEU A   8
LEU A 255
LEU A  55
 None
 1.26A 2oaxE-5nuxA:
undetectable		 2oaxE-5nuxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 PHE A 166
HIS A  39
VAL A  51
LEU A  83
LEU A  72
 None
 1.43A 2prgB-5nuxA:
undetectable		 2prgB-5nuxA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 11 LEU A 317
ILE A 297
GLY A 295
LEU A  19
LEU A 314
 None
None
FMN  A1001 (-3.7A)
None
None
 0.94A 2qmmA-5nuxA:
undetectable
2qmmB-5nuxA:
undetectable		 2qmmA-5nuxA:
undetectable
2qmmB-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 9 LEU A 317
ILE A 297
GLY A 295
LEU A  19
LEU A 314
 None
None
FMN  A1001 (-3.7A)
None
None
 1.02A 3ai9X-5nuxA:
undetectable		 3ai9X-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 PHE A   5
LEU A  19
GLY A 292
LEU A 316
LEU A   4
 None
 1.13A 3e23A-5nuxA:
undetectable		 3e23A-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 10 LEU A  86
ALA A 164
GLY A 157
VAL A  35
LEU A  83
 None
 1.03A 3ogpB-5nuxA:
undetectable		 3ogpB-5nuxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 10 LEU A  86
ALA A 164
GLY A 157
VAL A  35
LEU A  83
 None
 1.00A 3ogpA-5nuxA:
undetectable		 3ogpA-5nuxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 5 LEU A 178
GLY A 126
PHE A 182
PHE A 204
 None
 1.19A 3smtA-5nuxA:
undetectable		 3smtA-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 GLY A 105
GLY A 126
PHE A 132
GLU A  62
ALA A 108
 None
 1.31A 3t7sA-5nuxA:
undetectable		 3t7sA-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 GLY A 105
GLY A 126
PHE A 132
GLU A  62
ALA A 108
 None
 1.34A 3t7sB-5nuxA:
undetectable		 3t7sB-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 9 ALA A 102
HIS A 172
HIS A 175
TYR A 177
TYR A  27
 None
FMN  A1001 (-3.8A)
FMN  A1001 (-4.5A)
None
None
 1.29A 3upwA-5nuxA:
35.9		 3upwA-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 8 HIS A  39
TRP A  38
PRO A 113
TRP A 114
 None
 1.33A 3v35A-5nuxA:
11.2		 3v35A-5nuxA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 6 HIS A 172
HIS A 175
TYR A 177
TYR A  27
 FMN  A1001 (-3.8A)
FMN  A1001 (-4.5A)
None
None
 1.00A 4df2A-5nuxA:
35.8		 4df2A-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 9 PHE A 154
ALA A 158
ALA A 161
LEU A  83
LEU A 171
 None
 1.31A 4or0A-5nuxA:
undetectable		 4or0A-5nuxA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 4 LEU A 317
ILE A 297
PRO A 300
LEU A   4
 None
 0.89A 5eb3A-5nuxA:
undetectable		 5eb3A-5nuxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 VAL A 212
ILE A  99
LEU A 162
LEU A 220
VAL A 216
 None
 1.16A 5im2A-5nuxA:
undetectable		 5im2A-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 9 ALA A  60
THR A  59
ALA A  58
ALA A 102
GLY A  33
 None
None
FMN  A1001 (-3.3A)
None
None
 1.01A 5l5zK-5nuxA:
undetectable
5l5zL-5nuxA:
undetectable		 5l5zK-5nuxA:
19.49
5l5zL-5nuxA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 9 ALA A  60
THR A  59
ALA A  58
ALA A 102
GLY A  33
 None
None
FMN  A1001 (-3.3A)
None
None
 1.01A 5l5zY-5nuxA:
undetectable
5l5zZ-5nuxA:
undetectable		 5l5zY-5nuxA:
19.49
5l5zZ-5nuxA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 LEU A  41
LEU A  40
ILE A  90
LEU A  86
LEU A  48
 None
 1.00A 5toaB-5nuxA:
undetectable		 5toaB-5nuxA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		5 / 12 VAL A 215
LEU A 179
ALA A 211
GLY A 252
LEU A 251
 None
 0.97A 6b0iB-5nuxA:
4.3		 6b0iB-5nuxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 5nux CHROMATE REDUCTASE
(Thermus
scotoductus) 		4 / 6 SER A 184
ALA A 174
SER A 180
SER A 227
 None
 1.04A 6bocA-5nuxA:
undetectable
6bocB-5nuxA:
undetectable
6bocC-5nuxA:
undetectable
6bocD-5nuxA:
undetectable		 6bocA-5nuxA:
undetectable
6bocB-5nuxA:
undetectable
6bocC-5nuxA:
undetectable
6bocD-5nuxA:
undetectable