SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 5nv5 FIC FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 VAL A 204
ASP A  38
ILE A 130
LEU A  60
ILE A 190
 None
 1.20A 1d1gB-5nv5A:
undetectable		 1d1gB-5nv5A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 5nv5 FIC FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 11 ASP A  38
PHE A 186
ASP A  41
LEU A  60
ILE A  56
 None
 1.43A 3ko0K-5nv5A:
undetectable
3ko0L-5nv5A:
undetectable
3ko0M-5nv5A:
undetectable
3ko0N-5nv5A:
0.6		 3ko0K-5nv5A:
24.04
3ko0L-5nv5A:
24.04
3ko0M-5nv5A:
24.04
3ko0N-5nv5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5nv5 FIC FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 5 ASN A 124
GLU A  25
TYR A  65
PHE A  61
 None
 1.35A 4twdC-5nv5A:
2.8
4twdD-5nv5A:
2.5		 4twdC-5nv5A:
13.98
4twdD-5nv5A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5nv5 FIC FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 ILE A 149
GLY A 189
VAL A 143
LEU A 176
ALA A 175
 None
 1.05A 5o96C-5nv5A:
undetectable
5o96D-5nv5A:
undetectable		 5o96C-5nv5A:
undetectable
5o96D-5nv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5nv5 FIC FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A  60
GLY A 123
ASN A  11
ASP A  63
ASN A  58
 None
 1.07A 6mhtA-5nv5A:
undetectable		 6mhtA-5nv5A:
undetectable