SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.05A 1fkbA-5nv6A:
undetectable		 1fkbA-5nv6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.11A 1fklA-5nv6A:
undetectable		 1fklA-5nv6A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 GLY A 486
GLN A 443
THR A 292
ILE A 296
LEU A 382
 None
 1.41A 1m2zD-5nv6A:
undetectable		 1m2zD-5nv6A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 6 VAL A 505
THR A 504
LEU A 531
ARG A 533
 None
 0.94A 1s8fB-5nv6A:
undetectable		 1s8fB-5nv6A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 5 VAL A 112
GLY A 111
VAL A 113
TRP A 148
 None
 1.35A 1tkqB-5nv6A:
undetectable		 1tkqB-5nv6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.93A 2ceoA-5nv6A:
undetectable		 2ceoA-5nv6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 10 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.93A 2ceoB-5nv6A:
undetectable		 2ceoB-5nv6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.12A 2dg3A-5nv6A:
undetectable		 2dg3A-5nv6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.11A 2dg4A-5nv6A:
undetectable		 2dg4A-5nv6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 PHE A 492
LEU A 413
ASP A 483
ALA A 384
PHE A 380
 None
 1.14A 2g70A-5nv6A:
undetectable		 2g70A-5nv6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 PHE A 492
LEU A 413
ASP A 483
ALA A 384
PHE A 380
 None
 1.10A 2g70B-5nv6A:
undetectable		 2g70B-5nv6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 9 VAL A 113
THR A 109
VAL A 228
ASP A 221
VAL A 229
 None
 1.36A 2l8mA-5nv6A:
undetectable		 2l8mA-5nv6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 10 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.97A 2riwA-5nv6A:
undetectable
2riwB-5nv6A:
undetectable		 2riwA-5nv6A:
19.16
2riwB-5nv6A:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 11 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.89A 2xn5A-5nv6A:
undetectable		 2xn5A-5nv6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 10 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.88A 2xn6A-5nv6A:
undetectable
2xn6B-5nv6A:
undetectable		 2xn6A-5nv6A:
19.03
2xn6B-5nv6A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 6 ARG A  59
VAL A 322
ILE A 321
TYR A  61
 None
 1.17A 2yfbB-5nv6A:
undetectable		 2yfbB-5nv6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 8 HIS A 203
LEU A 269
LEU A 277
ASN A 361
 None
 1.02A 3lm8B-5nv6A:
undetectable
3lm8D-5nv6A:
undetectable		 3lm8B-5nv6A:
15.57
3lm8D-5nv6A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 LEU A 278
HIS A 365
LEU A 371
THR A 329
THR A 334
 None
None
ACT  A 701 ( 4.2A)
None
None
 1.30A 3thrA-5nv6A:
undetectable
3thrB-5nv6A:
undetectable
3thrC-5nv6A:
undetectable
3thrD-5nv6A:
undetectable		 3thrA-5nv6A:
20.09
3thrB-5nv6A:
20.09
3thrC-5nv6A:
20.09
3thrD-5nv6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 ASP A 356
LEU A 312
VAL A 363
THR A 276
LEU A 278
 None
 1.12A 3uq6B-5nv6A:
undetectable		 3uq6B-5nv6A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 ASP A 356
LEU A 312
VAL A 363
THR A 276
LEU A 278
 None
 1.07A 3vaqB-5nv6A:
undetectable		 3vaqB-5nv6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 7 VAL A 627
VAL A 625
ASN A 513
MET A 502
 None
 0.93A 4e1gB-5nv6A:
undetectable		 4e1gB-5nv6A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 8 GLU A 248
ASN A 266
GLY A 264
SER A 263
 None
 0.92A 4f93B-5nv6A:
undetectable		 4f93B-5nv6A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 LEU A 106
VAL A 228
LEU A 217
VAL A 212
VAL A 113
 None
 1.03A 4ib4A-5nv6A:
undetectable		 4ib4A-5nv6A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		3 / 5 GLY A 623
GLY A 535
GLU A 534
 None
 0.46A 4z2eA-5nv6A:
undetectable
4z2eD-5nv6A:
undetectable		 4z2eA-5nv6A:
22.78
4z2eD-5nv6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		3 / 3 ASP A 299
SER A 407
TYR A 488
 None
 0.86A 5glmA-5nv6A:
undetectable		 5glmA-5nv6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		3 / 3 SER A 516
LEU A 531
MET A 506
 None
 0.81A 5ikrB-5nv6A:
undetectable		 5ikrB-5nv6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		5 / 12 HIS A 174
VAL A 235
LEU A 156
LEU A 167
ALA A 170
 None
 1.47A 5xprA-5nv6A:
undetectable		 5xprA-5nv6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens) 		4 / 7 HIS A 626
PRO A 616
ASP A 617
SER A 471
 None
 1.32A 6g6rA-5nv6A:
undetectable		 6g6rA-5nv6A:
21.24