SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		5 / 12 GLN A  84
ASN A  59
GLY A  86
ALA A 169
GLY A 168
 None
 1.17A 3v3oA-5nvmA:
2.3		 3v3oA-5nvmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		5 / 11 GLN A  84
ASN A  59
GLY A  86
ALA A 169
GLY A 168
 None
 1.03A 4a6nA-5nvmA:
2.2		 4a6nA-5nvmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		4 / 7 ASP A 112
GLY A 109
THR A 108
PHE A 113
 None
 0.86A 4ac9C-5nvmA:
undetectable		 4ac9C-5nvmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		4 / 7 ASP A 112
GLY A 109
THR A 108
PHE A 113
 None
 0.87A 4acaC-5nvmA:
undetectable		 4acaC-5nvmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		4 / 8 ILE A 152
PHE A  88
LEU A 115
LEU A  56
 None
 0.90A 4qopC-5nvmA:
undetectable		 4qopC-5nvmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		4 / 7 ILE A 120
HIS A 114
LEU A 115
ALA A 169
 None
 1.01A 5hrqE-5nvmA:
undetectable
5hrqF-5nvmA:
undetectable
5hrqJ-5nvmA:
undetectable		 5hrqE-5nvmA:
9.35
5hrqF-5nvmA:
12.90
5hrqJ-5nvmA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		3 / 3 TYR A  78
TYR A  64
SER A 111
 None
 0.98A 5iktB-5nvmA:
undetectable		 5iktB-5nvmA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		3 / 3 LYS A 134
TRP A 135
SER A 181
 None
 1.00A 5nwwA-5nvmA:
undetectable		 5nwwA-5nvmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
GRB10-INTERACTING
GYF PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE A  94
LEU B  51
TRP A  95
ARG A  96
 None
None
None
PO4  B 101 (-2.9A)
 1.05A 5o4yA-5nvmA:
undetectable		 5o4yA-5nvmA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
GRB10-INTERACTING
GYF PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE A  94
LEU B  51
TRP A  95
ARG A  96
 None
None
None
PO4  B 101 (-2.9A)
 1.09A 5o4yF-5nvmA:
undetectable		 5o4yF-5nvmA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		5 / 12 HIS A 217
VAL A 170
VAL A 162
THR A 186
GLY A 132
 None
 1.42A 6brdA-5nvmA:
2.1		 6brdA-5nvmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens) 		5 / 12 HIS A 217
VAL A 162
THR A 186
GLY A 132
GLY A 133
 None
 1.20A 6brdB-5nvmA:
2.1		 6brdB-5nvmA:
17.20