SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 911
ASP A 938
ASN A 931
 None
 0.71A 1wg8B-5nvrA:
undetectable		 1wg8B-5nvrA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 216
ASN A 267
SER A 270
ILE A 271
ILE A 217
 None
 1.10A 2blaA-5nvrA:
undetectable		 2blaA-5nvrA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 6 SER A 417
ARG A 343
PHE A 381
PHE A 403
 None
 1.08A 2qeiA-5nvrA:
undetectable		 2qeiA-5nvrA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 6 SER A 417
PHE A 381
ILE A 377
PHE A 403
 None
 1.27A 2qeiA-5nvrA:
undetectable		 2qeiA-5nvrA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 530
ILE A 412
ILE A 463
ILE A 378
VAL A 423
 None
 0.98A 2ygoA-5nvrA:
undetectable		 2ygoA-5nvrA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 579
LEU A 595
ILE A 652
PRO A 651
PHE A 602
 None
 1.04A 2ygqA-5nvrA:
undetectable		 2ygqA-5nvrA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1159
LEU A1162
PHE A1166
LEU A1227
 None
 1.00A 3asnP-5nvrA:
undetectable
3asnW-5nvrA:
undetectable		 3asnP-5nvrA:
12.42
3asnW-5nvrA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 761
SER A 759
PHE A 758
ILE A 738
 None
 0.90A 3ko0B-5nvrA:
undetectable		 3ko0B-5nvrA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 761
SER A 759
PHE A 758
ILE A 738
 None
 0.88A 3ko0S-5nvrA:
undetectable		 3ko0S-5nvrA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 464
THR A 504
ASP A 533
LEU A 450
LEU A 523
 None
 1.38A 3lcvB-5nvrA:
undetectable		 3lcvB-5nvrA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 368
GLU A 269
ILE A 268
PHE A 364
ILE A 317
 None
 1.36A 3ndiA-5nvrA:
undetectable		 3ndiA-5nvrA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 778
ILE A 762
ASN A 681
PHE A 779
 None
 1.34A 3octA-5nvrA:
undetectable		 3octA-5nvrA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 328
PHE A 308
ILE A 311
PHE A 307
 None
 0.89A 3owxB-5nvrA:
undetectable		 3owxB-5nvrA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 350
VAL A 302
ARG A 306
 None
 0.73A 3p73A-5nvrA:
undetectable		 3p73A-5nvrA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 447
LEU A 523
ILE A 574
GLY A 529
LEU A 530
 None
 1.15A 3q95A-5nvrA:
undetectable		 3q95A-5nvrA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 374
PHE A 403
THR A 338
ILE A 377
THR A 366
 None
 1.38A 3um5A-5nvrA:
undetectable		 3um5A-5nvrA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1023
LEU A 996
GLN A1016
GLU A1052
 None
 1.18A 4i41A-5nvrA:
undetectable		 4i41A-5nvrA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 401
ASP A 522
ASP A 516
 None
 0.67A 4kicB-5nvrA:
undetectable		 4kicB-5nvrA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 534
GLY A 535
ARG A 537
GLU A 461
 None
 1.33A 4r82A-5nvrA:
undetectable
4r82B-5nvrA:
undetectable		 4r82A-5nvrA:
9.46
4r82B-5nvrA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 503
ILE A 476
ILE A 429
GLY A 430
LEU A 523
 None
 1.03A 4y8wC-5nvrA:
undetectable		 4y8wC-5nvrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 214
GLU A 218
GLY A 219
GLY A 220
 None
 0.76A 5a06D-5nvrA:
undetectable		 5a06D-5nvrA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 191
LYS A 214
GLU A 218
 None
 0.76A 5d0yA-5nvrA:
undetectable		 5d0yA-5nvrA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 355
ILE A 351
ILE A 350
TYR A 301
 None
 1.24A 5dnuA-5nvrA:
undetectable		 5dnuA-5nvrA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 355
ILE A 351
ILE A 350
TYR A 301
 None
 1.23A 5dnvA-5nvrA:
undetectable		 5dnvA-5nvrA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 941
LEU A 943
ILE A 969
PRO A 948
LEU A 947
 None
 1.26A 5g48B-5nvrA:
undetectable		 5g48B-5nvrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 583
CYH A 580
HIS A 647
LEU A 648
 None
 1.00A 5hrqE-5nvrA:
undetectable
5hrqF-5nvrA:
undetectable
5hrqJ-5nvrA:
undetectable		 5hrqE-5nvrA:
2.46
5hrqF-5nvrA:
2.49
5hrqJ-5nvrA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 407
PHE A 381
THR A 338
LEU A 369
 None
 0.75A 5hs1A-5nvrA:
undetectable		 5hs1A-5nvrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 533
ILE A 575
ILE A 691
ILE A 467
ILE A 463
 None
 1.03A 5hw8A-5nvrA:
undetectable
5hw8D-5nvrA:
undetectable		 5hw8A-5nvrA:
8.73
5hw8D-5nvrA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 476
PRO A 425
ILE A 433
LEU A 494
 None
 0.91A 5ieoA-5nvrA:
undetectable		 5ieoA-5nvrA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 6 LYS A1159
LEU A1162
PHE A1166
LEU A1227
 None
 1.05A 5w97C-5nvrA:
undetectable
5w97J-5nvrA:
undetectable		 5w97C-5nvrA:
12.42
5w97J-5nvrA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 418
THR A 414
CYH A 453
LEU A 404
 None
 1.12A 6cnjD-5nvrA:
2.7
6cnjE-5nvrA:
4.0		 6cnjD-5nvrA:
5.25
6cnjE-5nvrA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 418
THR A 414
CYH A 453
LEU A 404
 None
 1.32A 6cnjD-5nvrA:
2.7
6cnjE-5nvrA:
4.0		 6cnjD-5nvrA:
5.25
6cnjE-5nvrA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 499
LEU A 424
PRO A 420
LEU A 481
PHE A 480
 None
 1.13A 6hupA-5nvrA:
3.7
6hupB-5nvrA:
2.3		 6hupA-5nvrA:
6.15
6hupB-5nvrA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 575
PRO A 601
MET A 604
THR A 605
MET A 567
 None
 0.93A 6hupA-5nvrA:
3.7
6hupB-5nvrA:
2.3		 6hupA-5nvrA:
6.15
6hupB-5nvrA:
6.33