SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RD7_B_FOLB361_0 (DIHYDROFOLATE REDUCTASE)	5nwm	NUCLEAR RECEPTOR COACTIVATOR 1 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (Homo sapiens; Homo sapiens)	5 / 12	ALA A 340 THR A 264 ILE A 275 LEU B 806 ILE A 296	None	1.03A	1rd7B-5nwmA: undetectable	1rd7B-5nwmA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_B_RIMB299_1 (MATRIX PROTEIN 2)	5nwm	NUCLEAR RECEPTOR COACTIVATOR 1 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (Homo sapiens)	4 / 6	LEU B 805 LEU B 802 ASP B 801 ILE A 273	None	1.06A	2rlfB-5nwmB: undetectable 2rlfC-5nwmB: undetectable	2rlfB-5nwmB: 19.51 2rlfC-5nwmB: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H5F_A_SAMA301_0 (PROTEIN ARGININE N-METHYLTRANSFERASE SFM1)	5nwm	NUCLEAR RECEPTOR COACTIVATOR 1 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (Homo sapiens; Homo sapiens)	5 / 12	LEU A 313 ILE B 790 GLY A 270 ASP A 267 ALA A 310	None	1.13A	5h5fA-5nwmA: undetectable	5h5fA-5nwmA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RD7_B_FOLB361_0","DIHYDROFOLATE REDUCTASE","5nwm","NUCLEAR RECEPTOR COACTIVATOR 1;SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6","Homo sapiens;Homo sapiens",5,"ALA A 340;THR A 264;ILE A 275;LEU B 806;ILE A 296","None","1.03A","1rd7B-5nwmA:undetectable","1rd7B-5nwmA:undetectable"],["2RLF_B_RIMB299_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","5nwm","NUCLEAR RECEPTOR COACTIVATOR 1;SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6","Homo sapiens",4,"LEU B 805;LEU B 802;ASP B 801;ILE A 273","None","1.06A","2rlfB-5nwmB:undetectable;2rlfC-5nwmB:undetectable","2rlfB-5nwmB:19.51;2rlfC-5nwmB:19.51"],["5H5F_A_SAMA301_0","PROTEIN ARGININE N-METHYLTRANSFERASE SFM1","5nwm","NUCLEAR RECEPTOR COACTIVATOR 1;SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6","Homo sapiens;Homo sapiens",5,"LEU A 313;ILE B 790;GLY A 270;ASP A 267;ALA A 310","None","1.13A","5h5fA-5nwmA:undetectable","5h5fA-5nwmA:undetectable"]]