SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 8 LEU A 426
ASP A 168
LEU A 169
LEU A 170
 None
 1.06A 1e7cA-5nwsA:
3.8		 1e7cA-5nwsA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 GLN A 340
TYR A  40
VAL A 344
GLY A 422
 None
 1.17A 1ekjC-5nwsA:
undetectable
1ekjD-5nwsA:
undetectable		 1ekjC-5nwsA:
undetectable
1ekjD-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 VAL A 344
GLY A 422
GLN A 340
TYR A  40
 None
 1.11A 1ekjC-5nwsA:
undetectable
1ekjD-5nwsA:
undetectable		 1ekjC-5nwsA:
undetectable
1ekjD-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		3 / 3 GLN A 368
TYR A  66
ARG A  44
 None
 0.80A 1gtbA-5nwsA:
undetectable		 1gtbA-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 399
LEU A 406
ARG A 432
VAL A 167
ALA A 409
 None
 0.89A 1n5xA-5nwsA:
undetectable		 1n5xA-5nwsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 399
LEU A 406
ARG A 432
VAL A 167
ALA A 409
 None
 0.89A 1n5xB-5nwsA:
undetectable		 1n5xB-5nwsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		3 / 3 ALA A 267
THR A 271
CYH A 382
 HEM  A 504 (-3.4A)
HEM  A 504 (-3.9A)
HEM  A 504 (-2.3A)
 0.51A 3e4eA-5nwsA:
30.1		 3e4eA-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		3 / 3 ALA A 267
THR A 271
CYH A 382
 HEM  A 504 (-3.4A)
HEM  A 504 (-3.9A)
HEM  A 504 (-2.3A)
 0.44A 3e4eB-5nwsA:
30.1		 3e4eB-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 7 MET A 260
LEU A 241
ARG A 127
GLY A 384
 None
None
HEM  A 504 (-4.0A)
HEM  A 504 (-3.4A)
 1.00A 3hcnA-5nwsA:
undetectable		 3hcnA-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		3 / 3 ARG A 128
ILE A 115
THR A  81
 GOL  A 501 (-3.9A)
HEM  A 504 (-4.1A)
None
 0.71A 3ia4D-5nwsA:
undetectable		 3ia4D-5nwsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 7 TYR A 175
ASN A 278
LEU A 396
LEU A 170
 None
 1.23A 3nk2X-5nwsA:
undetectable		 3nk2X-5nwsA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 LEU A 406
ALA A 282
THR A 285
LEU A 429
 None
 1.00A 3t3zA-5nwsA:
29.8		 3t3zA-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 LEU A 431
ALA A 282
THR A 285
LEU A 426
 None
 0.99A 3t3zA-5nwsA:
29.8		 3t3zA-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 LEU A 406
ALA A 282
THR A 285
LEU A 429
 None
 0.99A 3t3zB-5nwsA:
29.8		 3t3zB-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 LEU A 406
ALA A 282
THR A 285
LEU A 429
 None
 1.01A 3t3zD-5nwsA:
29.7		 3t3zD-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5nws SAACMM
(Streptomyces
antibioticus) 		4 / 6 LEU A 431
ALA A 282
THR A 285
LEU A 426
 None
 1.00A 3t3zD-5nwsA:
29.7		 3t3zD-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5nws SAACMM
(Streptomyces
antibioticus) 		3 / 3 ARG A 152
LEU A 153
GLU A 156
 None
 0.74A 4l3gF-5nwsA:
undetectable		 4l3gF-5nwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 PHE A  37
ILE A 361
GLU A 414
ALA A 281
LEU A 283
 PG4  A 503 (-3.6A)
None
PG4  A 503 ( 4.6A)
None
None
 1.09A 5ienA-5nwsA:
undetectable		 5ienA-5nwsA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 GLU A 414
HIS A 286
ALA A 282
PRO A 413
LEU A 408
 PG4  A 503 ( 4.6A)
None
None
None
None
 1.29A 5nd2B-5nwsA:
undetectable		 5nd2B-5nwsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.20A 5uahC-5nwsA:
undetectable		 5uahC-5nwsA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.48A 5uhbC-5nwsA:
undetectable		 5uhbC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.40A 5uhcC-5nwsA:
0.0		 5uhcC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.43A 5uhdC-5nwsA:
undetectable		 5uhdC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.44A 5uhgC-5nwsA:
undetectable		 5uhgC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5nws SAACMM
(Streptomyces
antibioticus) 		5 / 12 TYR A 221
VAL A 130
THR A 131
LEU A 262
VAL A 186
 None
 1.09A 6a93B-5nwsA:
undetectable		 6a93B-5nwsA:
undetectable