SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 276
TRP A 274
TRP A 243
 None
 1.24A 1c4dA-5nx2A:
undetectable
1c4dB-5nx2A:
undetectable		 1c4dA-5nx2A:
4.45
1c4dB-5nx2A:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A 321
ASN A 320
GLU A 247
GLY A 248
 None
 0.70A 1ykiA-5nx2A:
undetectable
1ykiB-5nx2A:
undetectable		 1ykiA-5nx2A:
18.62
1ykiB-5nx2A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A 321
ASN A 320
GLU A 247
GLY A 248
 None
 0.70A 1ykiA-5nx2A:
undetectable
1ykiB-5nx2A:
undetectable		 1ykiA-5nx2A:
18.62
1ykiB-5nx2A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A 321
ASN A 320
GLU A 247
GLY A 248
 None
 0.70A 1ykiC-5nx2A:
undetectable
1ykiD-5nx2A:
undetectable		 1ykiC-5nx2A:
18.62
1ykiD-5nx2A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A 321
ASN A 320
GLU A 247
GLY A 248
 None
 0.70A 1ykiC-5nx2A:
undetectable
1ykiD-5nx2A:
undetectable		 1ykiC-5nx2A:
18.62
1ykiD-5nx2A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 7 TYR A  88
TRP A 214
TYR A  69
ARG A 215
 None
 1.30A 3wipA-5nx2A:
undetectable
3wipB-5nx2A:
undetectable		 3wipA-5nx2A:
19.46
3wipB-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 TYR A  88
TRP A 214
TYR A  69
ARG A 215
 None
 1.36A 3wipB-5nx2A:
undetectable
3wipC-5nx2A:
undetectable		 3wipB-5nx2A:
19.46
3wipC-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 TYR A  88
TRP A 214
TYR A  69
ARG A 215
 None
 1.29A 3wipC-5nx2A:
undetectable
3wipD-5nx2A:
undetectable		 3wipC-5nx2A:
19.46
3wipD-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 TYR A  88
TRP A 214
TYR A  69
ARG A 215
 None
 1.35A 3wipD-5nx2A:
undetectable
3wipE-5nx2A:
undetectable		 3wipD-5nx2A:
19.46
3wipE-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 ARG A 215
TYR A  88
TRP A 214
TYR A  69
 None
 1.36A 3wipA-5nx2A:
undetectable
3wipE-5nx2A:
undetectable		 3wipA-5nx2A:
19.46
3wipE-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 7 TYR A  88
TRP A 214
TYR A  69
ARG A 215
 None
 1.30A 3wipF-5nx2A:
undetectable
3wipG-5nx2A:
undetectable		 3wipF-5nx2A:
19.46
3wipG-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 ARG A 215
TYR A  88
TRP A 214
TYR A  69
 None
 1.29A 3wipF-5nx2A:
undetectable
3wipJ-5nx2A:
undetectable		 3wipF-5nx2A:
19.46
3wipJ-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 SER A 301
MET A 303
ARG A 380
TRP A 306
 None
 1.19A 4cx7C-5nx2A:
undetectable
4cx7D-5nx2A:
0.4		 4cx7C-5nx2A:
21.04
4cx7D-5nx2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 149
LEU A 388
TYR A 152
ARG A 190
 None
 1.01A 4m5mA-5nx2A:
undetectable		 4m5mA-5nx2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A 121
ASP A  67
TRP A  72
 None
 0.95A 4xdqA-5nx2A:
undetectable		 4xdqA-5nx2A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A  39
ARG A  40
LEU A 218
 None
 0.92A 5dbyA-5nx2A:
undetectable		 5dbyA-5nx2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 6 PHE A 187
SER A 193
ALA A 191
LEU A 189
 None
 1.17A 5dzkB-5nx2A:
undetectable
5dzkP-5nx2A:
undetectable		 5dzkB-5nx2A:
21.43
5dzkP-5nx2A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 6 PHE A 187
SER A 193
ALA A 191
LEU A 189
 None
 1.26A 5dzkg-5nx2A:
undetectable
5dzku-5nx2A:
undetectable		 5dzkg-5nx2A:
21.43
5dzku-5nx2A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens) 		4 / 5 TYR A 250
ASN A 177
TYR A 178
PHE A 266
 None
 1.20A 6h3dA-5nx2A:
undetectable		 6h3dA-5nx2A:
20.97