SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5nx4 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		5 / 11 PHE A  82
ILE A 116
ALA A  97
THR A 100
VAL A 144
 None
 1.18A 3rukD-5nx4A:
undetectable		 3rukD-5nx4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5nx4 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 8 ASP A 226
ASP A  79
ASP A  80
GLU A 219
 None
 1.10A 4feuD-5nx4A:
undetectable		 4feuD-5nx4A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5nx4 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		3 / 3 ARG A 126
ASP A 122
ARG A  24
 GOL  A 403 ( 4.0A)
GOL  A 403 (-2.5A)
GOL  A 403 (-4.2A)
 0.96A 4mx0A-5nx4A:
undetectable		 4mx0A-5nx4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5nx4 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		3 / 3 GLU A 142
TYR A 288
GLU A 186
 None
 0.80A 4ryaA-5nx4A:
undetectable		 4ryaA-5nx4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5nx4 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 GLU A 281
VAL A 280
LEU A 292
ALA A 197
GLY A 270
 None
 1.27A 5syeB-5nx4A:
undetectable		 5syeB-5nx4A:
21.22