SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		3 / 3 TRP A 126
VAL A 103
TRP A 145
 None
 1.33A 1c4dC-5nx7A:
undetectable
1c4dD-5nx7A:
undetectable		 1c4dC-5nx7A:
14.12
1c4dD-5nx7A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 5 HIS A 152
TRP A 145
ALA A 121
TRP A  76
 None
 1.23A 1dy4A-5nx7A:
undetectable		 1dy4A-5nx7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 6 PRO A  18
LEU A  61
ARG A  22
GLY A  64
 None
None
NDS  A 406 (-4.0A)
NDS  A 406 (-3.3A)
 0.95A 2hs2B-5nx7A:
undetectable		 2hs2B-5nx7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 4 ILE A 302
GLN A 214
ILE A 268
LEU A 237
 None
 1.26A 3dzyD-5nx7A:
1.9		 3dzyD-5nx7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		3 / 3 ARG A 139
GLU A 194
ASP A 287
 None
 0.87A 3g2oA-5nx7A:
undetectable		 3g2oA-5nx7A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 8 HIS A 152
LEU A  36
TRP A 330
ASP A  82
 None
 1.10A 3n2oC-5nx7A:
2.8
3n2oD-5nx7A:
3.2		 3n2oC-5nx7A:
17.86
3n2oD-5nx7A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		6 / 12 ALA A  23
GLY A  55
GLY A  70
LEU A 183
LEU A 186
ALA A  52
 None
None
None
0FV  A 400 (-4.7A)
None
None
 1.48A 4lg1A-5nx7A:
undetectable		 4lg1A-5nx7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		6 / 12 ALA A  23
GLY A  55
GLY A  70
LEU A 183
LEU A 186
ALA A  52
 None
None
None
0FV  A 400 (-4.7A)
None
None
 1.47A 4lg1B-5nx7A:
undetectable		 4lg1B-5nx7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		6 / 12 ALA A  23
GLY A  55
GLY A  70
LEU A 183
LEU A 186
ALA A  52
 None
None
None
0FV  A 400 (-4.7A)
None
None
 1.47A 4lg1C-5nx7A:
undetectable		 4lg1C-5nx7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		7 / 9 ASP A  81
ARG A 174
ASN A 220
SER A 224
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.69A 5dz2A-5nx7A:
38.8		 5dz2A-5nx7A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		7 / 9 ASP A  81
ARG A 174
ASN A 220
SER A 224
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.66A 5dz2B-5nx7A:
39.0		 5dz2B-5nx7A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		8 / 10 ASP A  81
ARG A 174
ASN A 220
SER A 224
LYS A 227
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
0FV  A 400 ( 2.5A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.56A 5ermA-5nx7A:
22.5		 5ermA-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		5 / 10 ASP A  81
ARG A 174
ASN A 220
SER A 224
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
0FV  A 400 ( 4.4A)
 1.23A 5ermA-5nx7A:
22.5		 5ermA-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		5 / 10 ASP A  81
ASP A  85
LYS A 227
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
MG  A 403 ( 4.6A)
0FV  A 400 ( 2.5A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.88A 5ermA-5nx7A:
22.5		 5ermA-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		6 / 10 ASP A 233
ARG A 174
ASN A 220
SER A 224
LYS A 227
TYR A 315
 None
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
0FV  A 400 ( 2.5A)
0FV  A 400 ( 4.4A)
 1.19A 5ermA-5nx7A:
22.5		 5ermA-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		8 / 9 ASP A  81
ARG A 174
ASN A 220
SER A 224
LYS A 227
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
0FV  A 400 ( 2.5A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.47A 5ermB-5nx7A:
9.1		 5ermB-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 8 PHE A 267
ARG A 303
ILE A 302
GLY A 304
 None
 0.89A 5nzxA-5nx7A:
undetectable		 5nzxA-5nx7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 5 ASN A 217
ASP A 221
ASN A 236
ASP A 233
 LA6  A 401 (-4.4A)
None
None
None
 1.45A 5vooC-5nx7A:
undetectable		 5vooC-5nx7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A  27
LEU A 118
TRP A  30
LEU A 125
ILE A  73
 None
 1.09A 5xprA-5nx7A:
2.5		 5xprA-5nx7A:
21.70