SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 ASN A 352
THR A 345
GLY A 320
ASP A 319
 None
 0.86A 1bu5A-5nxkA:
undetectable		 1bu5A-5nxkA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 12 LEU A 440
LEU A 393
ILE A 447
ILE A 432
LEU A 472
 None
 1.23A 1tw4B-5nxkA:
undetectable		 1tw4B-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 LEU A 424
MET A 474
THR A 473
LEU A 472
 None
 1.09A 2eikA-5nxkA:
undetectable
2eikJ-5nxkA:
undetectable		 2eikA-5nxkA:
undetectable
2eikJ-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 6 LEU A 424
MET A 474
THR A 473
LEU A 472
 None
 1.06A 2eilA-5nxkA:
undetectable
2eilJ-5nxkA:
undetectable		 2eilA-5nxkA:
undetectable
2eilJ-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 6 LEU A 424
MET A 474
THR A 473
LEU A 472
 None
 1.10A 2zxwA-5nxkA:
undetectable
2zxwJ-5nxkA:
undetectable		 2zxwA-5nxkA:
undetectable
2zxwJ-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 LEU A 424
MET A 474
THR A 473
LEU A 472
 None
 1.07A 3ablA-5nxkA:
undetectable
3ablJ-5nxkA:
undetectable		 3ablA-5nxkA:
undetectable
3ablJ-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 6 LEU A 424
MET A 474
THR A 473
LEU A 472
 None
 1.07A 3abmA-5nxkA:
undetectable
3abmJ-5nxkA:
undetectable		 3abmA-5nxkA:
undetectable
3abmJ-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		3 / 3 GLY A 329
GLY A 381
GLY A 357
 None
 0.32A 3bogD-5nxkA:
undetectable		 3bogD-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.90A 3u5kA-5nxkA:
undetectable		 3u5kA-5nxkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.98A 3u5kB-5nxkA:
undetectable		 3u5kB-5nxkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.89A 3u5kC-5nxkA:
undetectable		 3u5kC-5nxkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 12 LEU A 536
VAL A 502
LEU A 472
ILE A 430
LEU A 424
 None
 1.36A 3w67D-5nxkA:
undetectable		 3w67D-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 9 GLY A 321
LEU A 335
LEU A 275
ASN A 293
ILE A 297
 None
 1.17A 3wdmC-5nxkA:
undetectable		 3wdmC-5nxkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 5 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.94A 4a9jA-5nxkA:
undetectable		 4a9jA-5nxkA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 5 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.94A 4a9jC-5nxkA:
undetectable		 4a9jC-5nxkA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		3 / 3 ASP A 509
ARG A 545
ASP A 417
 None
 0.80A 4fp9D-5nxkA:
undetectable		 4fp9D-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 12 VAL A 426
VAL A 464
LEU A 424
LEU A 472
MET A 504
 None
 1.22A 4i1rA-5nxkA:
undetectable		 4i1rA-5nxkA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 4 LYS A 332
ASN A 299
ASP A 277
ASP A 334
 None
 1.32A 4o1eB-5nxkA:
undetectable		 4o1eB-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 12 GLY A 357
GLY A 381
ILE A 333
GLY A 300
ASN A 325
 None
 1.07A 4obwB-5nxkA:
undetectable		 4obwB-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 ALA A 368
THR A 341
ALA A 340
THR A 391
 None
 0.88A 4qw0K-5nxkA:
undetectable		 4qw0K-5nxkA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 ALA A 368
THR A 341
ALA A 340
THR A 391
 None
 0.88A 4qw0Y-5nxkA:
undetectable		 4qw0Y-5nxkA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 7 THR A 345
GLY A 320
GLY A 321
ALA A 315
ILE A 295
 None
 1.15A 4yjiA-5nxkA:
undetectable		 4yjiA-5nxkA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		5 / 12 VAL A 502
LEU A 472
LEU A 536
VAL A 464
LEU A 528
 None
 1.09A 5ikrB-5nxkA:
undetectable		 5ikrB-5nxkA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 4 LEU A 373
MET A 449
ILE A 337
LEU A 387
 None
 1.28A 5nfpA-5nxkA:
undetectable		 5nfpA-5nxkA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 7 THR A 372
LEU A 373
VAL A 366
TYR A 363
 None
 1.01A 5ov9A-5nxkA:
undetectable		 5ov9A-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 THR A 372
LEU A 373
VAL A 366
TYR A 363
 None
 1.02A 5ov9B-5nxkA:
undetectable		 5ov9B-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.90A 5y1yA-5nxkA:
undetectable		 5y1yA-5nxkA:
23.08