SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A 188
VAL A 140
TRP A 144
 None
 0.81A 1av2C-5nxyA:
undetectable
1av2D-5nxyA:
undetectable		 1av2C-5nxyA:
undetectable
1av2D-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A  60
VAL A 218
TRP A  99
 None
 0.80A 1nt6A-5nxyA:
undetectable		 1nt6A-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A  60
VAL A 218
TRP A  99
 None
 0.80A 1nt6B-5nxyA:
undetectable		 1nt6B-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A 188
VAL A 140
TRP A 144
 None
 0.81A 1w5uC-5nxyA:
undetectable
1w5uD-5nxyA:
undetectable		 1w5uC-5nxyA:
undetectable
1w5uD-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ASN A 250
TYR A  63
SER A 190
 None
1Y8  A 301 ( 3.6A)
None
 0.86A 2gvcB-5nxyA:
undetectable		 2gvcB-5nxyA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ASN A 250
TYR A  63
SER A 190
 None
1Y8  A 301 ( 3.6A)
None
 0.87A 2gvcE-5nxyA:
undetectable		 2gvcE-5nxyA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		4 / 7 ASP A 101
SER A 216
VAL A 218
LEU A  72
 None
 1.01A 2hdnE-5nxyA:
undetectable
2hdnF-5nxyA:
undetectable
2hdnH-5nxyA:
undetectable		 2hdnE-5nxyA:
21.05
2hdnF-5nxyA:
11.68
2hdnH-5nxyA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		4 / 7 SER A 216
VAL A 218
LEU A  72
ASP A 101
 None
 1.05A 2hdnF-5nxyA:
undetectable
2hdnG-5nxyA:
undetectable
2hdnH-5nxyA:
undetectable		 2hdnF-5nxyA:
11.68
2hdnG-5nxyA:
21.05
2hdnH-5nxyA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 TRP A  99
ALA A  60
VAL A 218
 None
 0.77A 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable		 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 TRP A 144
ALA A 188
VAL A 140
 None
 0.77A 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable		 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 11 ALA A  10
SER A  16
TYR A 103
ALA A  60
GLY A   9
 None
 1.44A 2xfsB-5nxyA:
undetectable		 2xfsB-5nxyA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		4 / 5 ILE A 195
THR A 108
PHE A 210
PHE A 111
 None
 1.18A 3em0A-5nxyA:
undetectable		 3em0A-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 TYR A 143
TYR A 189
ILE A 171
 None
1Y8  A 301 (-3.5A)
None
 0.69A 3eteA-5nxyA:
2.3
3eteB-5nxyA:
2.5		 3eteA-5nxyA:
11.63
3eteB-5nxyA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 12 ALA A  60
GLN A  25
ILE A 241
LEU A 249
TYR A  63
 None
None
None
None
1Y8  A 301 ( 3.6A)
 1.20A 3ia4A-5nxyA:
undetectable		 3ia4A-5nxyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 12 ALA A  60
GLN A  25
ILE A 241
LEU A 249
TYR A  63
 None
None
None
None
1Y8  A 301 ( 3.6A)
 1.21A 3ia4B-5nxyA:
undetectable		 3ia4B-5nxyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 12 ALA A  60
GLN A  25
ILE A 241
LEU A 249
TYR A  63
 None
None
None
None
1Y8  A 301 ( 3.6A)
 1.23A 3ia4C-5nxyA:
undetectable		 3ia4C-5nxyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A  85
ARG A  89
LYS A  93
 None
 0.79A 3kp3B-5nxyA:
undetectable		 3kp3B-5nxyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A  60
VAL A 218
TRP A  99
 None
 0.76A 3l8lA-5nxyA:
undetectable
3l8lB-5nxyA:
undetectable		 3l8lA-5nxyA:
undetectable
3l8lB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A 188
VAL A 140
TRP A 144
 None
 0.79A 3l8lA-5nxyA:
undetectable
3l8lB-5nxyA:
undetectable		 3l8lA-5nxyA:
undetectable
3l8lB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		3 / 3 ALA A 188
VAL A 140
TRP A 144
 None
 0.83A 3l8lC-5nxyA:
undetectable
3l8lD-5nxyA:
undetectable		 3l8lC-5nxyA:
undetectable
3l8lD-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 9 ASN A  44
TYR A  63
TYR A 109
TYR A 189
TYR A 213
 1Y8  A 301 ( 4.2A)
1Y8  A 301 ( 3.6A)
1Y8  A 301 (-4.1A)
1Y8  A 301 (-3.5A)
1Y8  A 301 (-3.3A)
 0.92A 3ppoA-5nxyA:
42.4		 3ppoA-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 9 TYR A  63
ASN A 107
TYR A 109
TYR A 189
TYR A 213
 1Y8  A 301 ( 3.6A)
1Y8  A 301 (-3.8A)
1Y8  A 301 (-4.1A)
1Y8  A 301 (-3.5A)
1Y8  A 301 (-3.3A)
 0.49A 3ppoA-5nxyA:
42.4		 3ppoA-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 9 ASN A  44
TYR A  63
TYR A 109
TYR A 189
TYR A 213
 1Y8  A 301 ( 4.2A)
1Y8  A 301 ( 3.6A)
1Y8  A 301 (-4.1A)
1Y8  A 301 (-3.5A)
1Y8  A 301 (-3.3A)
 0.93A 3ppoB-5nxyA:
42.3		 3ppoB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		5 / 9 TYR A  63
ASN A 107
TYR A 109
TYR A 189
TYR A 213
 1Y8  A 301 ( 3.6A)
1Y8  A 301 (-3.8A)
1Y8  A 301 (-4.1A)
1Y8  A 301 (-3.5A)
1Y8  A 301 (-3.3A)
 0.46A 3ppoB-5nxyA:
42.3		 3ppoB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		4 / 5 ILE A   8
GLN A  23
ILE A 233
GLU A 229
 None
 1.17A 4a99D-5nxyA:
undetectable		 4a99D-5nxyA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		4 / 5 TYR A 267
ILE A  18
TYR A 103
ILE A  19
 None
 1.02A 4jtpA-5nxyA:
undetectable		 4jtpA-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC
(Bacillus
subtilis) 		4 / 6 GLU A  17
ASP A 254
ASP A 192
ASN A 107
 None
None
None
1Y8  A 301 (-3.8A)
 1.27A 4ntxA-5nxyA:
undetectable
4ntxC-5nxyA:
undetectable		 4ntxA-5nxyA:
11.00
4ntxC-5nxyA:
18.81