SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ny5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 11 LEU A 234
LEU A 330
LEU A 212
VAL A 167
ILE A 169
 None
 1.10A 1ee2A-5ny5A:
undetectable		 1ee2A-5ny5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 11 LEU A 234
LEU A 330
LEU A 212
VAL A 167
ILE A 169
 None
 1.13A 1ee2B-5ny5A:
undetectable		 1ee2B-5ny5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 LEU A 204
ALA A 156
LEU A 155
PHE A 129
ILE A 304
 None
 1.28A 1mx8A-5ny5A:
undetectable		 1mx8A-5ny5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 5 PRO A 138
ASN A 140
VAL A  73
ILE A  71
 None
 1.05A 1z2bC-5ny5A:
undetectable		 1z2bC-5ny5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		3 / 3 GLN A 318
HIS A  76
ARG A  81
 None
 1.01A 1zlqA-5ny5A:
undetectable		 1zlqA-5ny5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 GLY A 332
LEU A 333
LEU A 330
ILE A 218
ARG A  79
 None
 1.09A 2f8dA-5ny5A:
undetectable		 2f8dA-5ny5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 GLY A 332
LEU A 333
LEU A 330
ILE A 218
ARG A  79
 None
 1.06A 2f8dB-5ny5A:
undetectable		 2f8dB-5ny5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 GLU A 326
GLY A 219
VAL A 101
ALA A 100
LEU A  93
 None
 1.19A 3a3yA-5ny5A:
undetectable		 3a3yA-5ny5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 6 ILE A 190
ILE A 216
TYR A 217
LEU A 184
 None
 1.10A 3adsA-5ny5A:
undetectable		 3adsA-5ny5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 4 ARG A 241
ASP A   7
ASP A 213
PRO A 214
 None
 1.43A 3fgrB-5ny5A:
undetectable		 3fgrB-5ny5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		3 / 3 ARG A 475
GLU A 480
ASP A 482
 None
 0.61A 3g2oA-5ny5A:
undetectable		 3g2oA-5ny5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 ARG A 260
ALA A 259
LEU A 234
LEU A 247
VAL A 110
 None
 0.96A 3o02A-5ny5A:
undetectable
3o02B-5ny5A:
undetectable		 3o02A-5ny5A:
21.44
3o02B-5ny5A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 6 ARG A 132
ASP A 178
ASP A 130
ARG A 177
 None
 1.26A 4kcnA-5ny5A:
undetectable		 4kcnA-5ny5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 6 ARG A 132
ASP A 178
ASP A 130
ARG A 177
 None
 1.22A 4kcnB-5ny5A:
undetectable		 4kcnB-5ny5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 SER A 338
LEU A 365
ALA A 356
ASN A 353
ALA A 388
 None
 1.09A 4x1kA-5ny5A:
undetectable
4x1kB-5ny5A:
undetectable		 4x1kA-5ny5A:
21.31
4x1kB-5ny5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 6 ILE A  12
ARG A  70
ILE A 316
GLU A 262
 None
GOL  A 502 (-2.5A)
None
None
 1.33A 4zzcA-5ny5A:
undetectable
4zzcB-5ny5A:
undetectable		 4zzcA-5ny5A:
20.08
4zzcB-5ny5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 6 ILE A  12
ARG A  70
ILE A 316
GLU A 262
 None
GOL  A 502 (-2.5A)
None
None
 1.36A 4zzcB-5ny5A:
undetectable
4zzcC-5ny5A:
undetectable		 4zzcB-5ny5A:
20.08
4zzcC-5ny5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 5 GLU A 160
LYS A 196
ASP A 158
HIS A 189
 None
 1.23A 5a06A-5ny5A:
undetectable		 5a06A-5ny5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 5 GLU A 326
THR A 319
THR A 141
HIS A 285
 None
 1.29A 5axaA-5ny5A:
undetectable		 5axaA-5ny5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 5 GLU A 326
THR A 319
THR A 141
HIS A 285
 None
 1.29A 5axaC-5ny5A:
undetectable		 5axaC-5ny5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 LEU A   8
THR A 329
LEU A 330
ILE A 208
ARG A 241
 None
 1.48A 5dlvA-5ny5A:
undetectable		 5dlvA-5ny5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 4 ALA A 186
PRO A 302
LEU A 172
HIS A 170
 None
 1.35A 5eskA-5ny5A:
undetectable		 5eskA-5ny5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		4 / 6 HIS A 327
LEU A 330
CYH A 150
LEU A 320
 None
 1.47A 5hrqD-5ny5A:
undetectable
5hrqG-5ny5A:
undetectable
5hrqH-5ny5A:
undetectable		 5hrqD-5ny5A:
4.65
5hrqG-5ny5A:
4.26
5hrqH-5ny5A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 9 LEU A 368
ILE A 387
GLU A 403
VAL A 405
GLU A 336
 None
None
GOL  A 501 ( 4.2A)
None
None
 1.48A 5igzA-5ny5A:
undetectable		 5igzA-5ny5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 ALA A  82
LEU A  86
GLY A  87
ILE A 258
LEU A 247
 None
 1.21A 5oy01-5ny5A:
undetectable
5oy07-5ny5A:
undetectable		 5oy01-5ny5A:
9.94
5oy07-5ny5A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 LEU A  72
ILE A   5
SER A  10
ALA A  11
HIS A  76
 None
 1.12A 6n91A-5ny5A:
undetectable		 6n91A-5ny5A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 LEU A  72
ILE A   5
SER A  10
ALA A  11
HIS A  76
 None
 1.11A 6n91B-5ny5A:
undetectable		 6n91B-5ny5A:
11.34