SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 TRP A 117
ALA A  79
VAL A 138
 None
 0.84A 1bdwA-5nyyA:
undetectable
1bdwB-5nyyA:
undetectable		 1bdwA-5nyyA:
5.42
1bdwB-5nyyA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.20A 1om5A-5nyyA:
undetectable
1om5B-5nyyA:
undetectable		 1om5A-5nyyA:
21.71
1om5B-5nyyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.29A 1rs6A-5nyyA:
undetectable
1rs6B-5nyyA:
undetectable		 1rs6A-5nyyA:
21.71
1rs6B-5nyyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 ALA A 291
VAL A 138
TRP A 117
 MRD  A 403 ( 3.8A)
None
None
 0.84A 1tkqA-5nyyA:
undetectable		 1tkqA-5nyyA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 PRO A 251
THR A 247
PRO A 245
 None
 0.80A 2d55C-5nyyA:
undetectable		 2d55C-5nyyA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		5 / 12 GLY A 265
GLY A 264
ALA A 281
ASN A 226
PHE A  88
 None
CA  A 407 ( 3.7A)
None
None
None
 1.13A 2dpmA-5nyyA:
undetectable		 2dpmA-5nyyA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.20A 2g6hA-5nyyA:
undetectable
2g6hB-5nyyA:
undetectable		 2g6hA-5nyyA:
22.56
2g6hB-5nyyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 6 SER A 290
SER A 139
ASP A  78
ASP A 288
 None
 1.22A 2j2pE-5nyyA:
undetectable
2j2pF-5nyyA:
undetectable		 2j2pE-5nyyA:
20.72
2j2pF-5nyyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.25A 3b3pA-5nyyA:
undetectable
3b3pB-5nyyA:
undetectable		 3b3pA-5nyyA:
21.71
3b3pB-5nyyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.14A 3e7gC-5nyyA:
undetectable
3e7gD-5nyyA:
undetectable		 3e7gC-5nyyA:
20.91
3e7gD-5nyyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		5 / 12 GLU A 161
ARG A  47
ALA A 246
ASP A 233
GLY A 253
 None
 1.39A 3jzjA-5nyyA:
undetectable		 3jzjA-5nyyA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 VAL A  70
VAL A  76
TRP A 117
 None
 0.90A 3l8lA-5nyyA:
undetectable
3l8lB-5nyyA:
undetectable		 3l8lA-5nyyA:
5.42
3l8lB-5nyyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.17A 3nlqA-5nyyA:
undetectable
3nlqB-5nyyA:
undetectable		 3nlqA-5nyyA:
22.45
3nlqB-5nyyA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 8 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.20A 4uchA-5nyyA:
undetectable
4uchB-5nyyA:
undetectable		 4uchA-5nyyA:
20.56
4uchB-5nyyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.14A 4v3wA-5nyyA:
undetectable
4v3wB-5nyyA:
undetectable		 4v3wA-5nyyA:
21.71
4v3wB-5nyyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 ASP A 233
ARG A 153
PRO A 155
 None
 1.03A 4wanC-5nyyA:
undetectable		 4wanC-5nyyA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		5 / 12 GLY A 206
HIS A 185
ASN A 226
GLN A 191
CYH A 269
 None
None
None
CA  A 406 ( 4.2A)
CD  A 401 (-2.4A)
 1.22A 4ypaC-5nyyA:
undetectable		 4ypaC-5nyyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		5 / 12 HIS A 185
ASN A 226
GLN A 191
CYH A 269
ILE A 189
 None
None
CA  A 406 ( 4.2A)
CD  A 401 (-2.4A)
None
 1.08A 4ypaC-5nyyA:
undetectable		 4ypaC-5nyyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 THR A  77
ASP A  78
ALA A  79
 None
 0.00A 5g5gB-5nyyA:
undetectable		 5g5gB-5nyyA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		5 / 12 THR A  48
GLU A  33
GLY A  32
ALA A  37
ALA A 280
 None
 1.23A 5kvaA-5nyyA:
undetectable		 5kvaA-5nyyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		5 / 12 THR A  48
GLU A  33
GLY A  32
ALA A  37
ALA A 280
 None
 1.18A 5kvaB-5nyyA:
undetectable		 5kvaB-5nyyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.19A 5uo9A-5nyyA:
undetectable
5uo9B-5nyyA:
undetectable		 5uo9A-5nyyA:
20.76
5uo9B-5nyyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.16A 5uo9C-5nyyA:
undetectable
5uo9D-5nyyA:
undetectable		 5uo9C-5nyyA:
20.76
5uo9D-5nyyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 5 TRP A 230
THR A 262
ASN A 285
TRP A 235
 None
None
MRD  A 403 (-3.5A)
None
 1.49A 5vkqB-5nyyA:
undetectable
5vkqC-5nyyA:
undetectable		 5vkqB-5nyyA:
10.55
5vkqC-5nyyA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.11A 5vv9A-5nyyA:
undetectable
5vv9B-5nyyA:
undetectable		 5vv9A-5nyyA:
21.27
5vv9B-5nyyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.10A 5vvaA-5nyyA:
undetectable
5vvaB-5nyyA:
undetectable		 5vvaA-5nyyA:
21.27
5vvaB-5nyyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.13A 5vvdA-5nyyA:
undetectable
5vvdB-5nyyA:
undetectable		 5vvdA-5nyyA:
20.76
5vvdB-5nyyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		3 / 3 THR A 242
THR A 247
ARG A 248
 None
 1.05A 5wm2A-5nyyA:
undetectable		 5wm2A-5nyyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 6 ASP A  36
GLY A  44
PRO A  45
GLY A  32
 None
 0.72A 6ag0C-5nyyA:
undetectable		 6ag0C-5nyyA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.12A 6auuA-5nyyA:
undetectable
6auuB-5nyyA:
undetectable		 6auuA-5nyyA:
12.46
6auuB-5nyyA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.13A 6av6A-5nyyA:
undetectable
6av6B-5nyyA:
undetectable		 6av6A-5nyyA:
14.72
6av6B-5nyyA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE
(Thermomonospora
curvata) 		4 / 7 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.10A 6cieA-5nyyA:
undetectable
6cieB-5nyyA:
undetectable		 6cieA-5nyyA:
14.72
6cieB-5nyyA:
14.72