SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLN A 490
HIS A 140
PRO A 886
 None
CL  A1001 (-4.5A)
CL  A1001 (-4.4A)
 0.98A 1d8cA-5nz7A:
undetectable		 1d8cA-5nz7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 HIS A 677
TRP A 894
ALA A 754
TRP A 755
 None
 1.27A 1dy4A-5nz7A:
undetectable		 1dy4A-5nz7A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 MET A 694
LEU A 697
SER A 698
 None
 0.60A 1ee2A-5nz7A:
undetectable		 1ee2A-5nz7A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 282
PHE A 201
LEU A 182
VAL A 165
 None
 1.11A 1gsfA-5nz7A:
3.9		 1gsfA-5nz7A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 282
PHE A 201
LEU A 182
VAL A 165
 None
 1.11A 1gsfB-5nz7A:
1.8		 1gsfB-5nz7A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 282
PHE A 201
LEU A 182
VAL A 165
 None
 1.11A 1gsfD-5nz7A:
3.9		 1gsfD-5nz7A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 MET A 770
PHE A 714
ILE A 705
ALA A 709
ALA A 733
 None
 1.21A 1jb0B-5nz7A:
undetectable		 1jb0B-5nz7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A 108
PHE A  88
GLY A  46
VAL A  15
LEU A  18
 None
 1.06A 1mx1A-5nz7A:
undetectable		 1mx1A-5nz7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A 110
VAL A 112
TRP A 118
 None
 0.80A 1nt5A-5nz7A:
undetectable		 1nt5A-5nz7A:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A 110
VAL A 112
TRP A 118
 None
 0.80A 1nt5B-5nz7A:
undetectable		 1nt5B-5nz7A:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 262
GLY A 287
ILE A 234
SER A 163
ILE A 248
 None
 1.18A 1q8jB-5nz7A:
undetectable		 1q8jB-5nz7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ALA A 822
SER A 819
PHE A 753
ILE A 845
 None
 1.03A 1yc2A-5nz7A:
undetectable		 1yc2A-5nz7A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 453
ALA A 508
SER A 509
THR A 482
 None
 1.06A 1yvpB-5nz7A:
undetectable		 1yvpB-5nz7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PHE A 459
PHE A 927
TYR A 456
TYR A 512
 None
 1.08A 2aoxA-5nz7A:
undetectable		 2aoxA-5nz7A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 453
ALA A 508
SER A 509
THR A 482
 None
 1.03A 2i91A-5nz7A:
undetectable		 2i91A-5nz7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 453
ALA A 508
SER A 509
THR A 482
 None
 1.05A 2i91B-5nz7A:
undetectable		 2i91B-5nz7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 SER A 175
LEU A 408
ASP A 413
GLU A 425
 None
 1.20A 2j2pE-5nz7A:
undetectable
2j2pF-5nz7A:
undetectable		 2j2pE-5nz7A:
12.96
2j2pF-5nz7A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 PRO A 137
HIS A 140
ASP A 166
TYR A 142
 None
CL  A1001 (-4.5A)
None
None
 1.01A 2lh8A-5nz7A:
undetectable		 2lh8A-5nz7A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 456
GLY A 454
PHE A 457
 None
 0.69A 2m2pB-5nz7A:
undetectable		 2m2pB-5nz7A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 HIS A 128
PRO A 869
TYR A 142
PRO A 137
 None
 1.49A 2ombA-5nz7A:
undetectable
2ombB-5nz7A:
undetectable		 2ombA-5nz7A:
11.58
2ombB-5nz7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMN_B_IPHB401_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 PRO A 137
HIS A 128
PRO A 869
TYR A 142
 None
 1.32A 2omnA-5nz7A:
1.0
2omnB-5nz7A:
1.4		 2omnA-5nz7A:
11.58
2omnB-5nz7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A 233
THR A 232
VAL A 165
GLY A 169
 None
 1.10A 2p2fA-5nz7A:
undetectable		 2p2fA-5nz7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 VAL A 233
THR A 232
VAL A 165
GLY A 169
 None
 1.11A 2p2fB-5nz7A:
undetectable		 2p2fB-5nz7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A 173
GLY A 148
ASN A 149
GLU A 262
ARG A 199
 None
 1.31A 2piwA-5nz7A:
undetectable		 2piwA-5nz7A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 167
GLN A 490
ARG A 199
GLN A 200
 None
 1.08A 2vxaA-5nz7A:
undetectable
2vxaC-5nz7A:
undetectable
2vxaE-5nz7A:
undetectable		 2vxaA-5nz7A:
5.46
2vxaC-5nz7A:
5.46
2vxaE-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A 490
ARG A 167
ARG A 199
GLN A 200
 None
 1.11A 2vxaA-5nz7A:
undetectable
2vxaB-5nz7A:
undetectable
2vxaK-5nz7A:
undetectable		 2vxaA-5nz7A:
5.46
2vxaB-5nz7A:
5.46
2vxaK-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A 490
ARG A 167
ARG A 199
GLN A 200
 None
 1.09A 2vxaB-5nz7A:
undetectable
2vxaC-5nz7A:
undetectable
2vxaG-5nz7A:
undetectable		 2vxaB-5nz7A:
5.46
2vxaC-5nz7A:
5.46
2vxaG-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 167
GLN A 490
ARG A 199
GLN A 200
 None
 1.07A 2vxaD-5nz7A:
undetectable
2vxaF-5nz7A:
undetectable
2vxaI-5nz7A:
undetectable		 2vxaD-5nz7A:
5.46
2vxaF-5nz7A:
5.46
2vxaI-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A 490
ARG A 167
ARG A 199
GLN A 200
 None
 1.11A 2vxaD-5nz7A:
undetectable
2vxaE-5nz7A:
undetectable
2vxaL-5nz7A:
undetectable		 2vxaD-5nz7A:
5.46
2vxaE-5nz7A:
5.46
2vxaL-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 199
GLN A 200
ARG A 167
GLN A 490
 None
 1.09A 2vxaF-5nz7A:
undetectable
2vxaG-5nz7A:
undetectable
2vxaI-5nz7A:
undetectable		 2vxaF-5nz7A:
5.46
2vxaG-5nz7A:
5.46
2vxaI-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 199
GLN A 200
GLN A 490
ARG A 167
 None
 1.06A 2vxaB-5nz7A:
undetectable
2vxaG-5nz7A:
undetectable
2vxaH-5nz7A:
undetectable		 2vxaB-5nz7A:
5.46
2vxaG-5nz7A:
5.46
2vxaH-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A 490
ARG A 167
ARG A 199
GLN A 200
 None
 1.10A 2vxaH-5nz7A:
undetectable
2vxaI-5nz7A:
undetectable
2vxaJ-5nz7A:
undetectable		 2vxaH-5nz7A:
5.46
2vxaI-5nz7A:
5.46
2vxaJ-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 199
GLN A 200
ARG A 167
GLN A 490
 None
 1.09A 2vxaD-5nz7A:
undetectable
2vxaJ-5nz7A:
undetectable
2vxaL-5nz7A:
undetectable		 2vxaD-5nz7A:
5.46
2vxaJ-5nz7A:
5.46
2vxaL-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 199
GLN A 200
GLN A 490
ARG A 167
 None
 1.10A 2vxaH-5nz7A:
undetectable
2vxaJ-5nz7A:
undetectable
2vxaK-5nz7A:
undetectable		 2vxaH-5nz7A:
5.46
2vxaJ-5nz7A:
5.46
2vxaK-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 199
GLN A 200
GLN A 490
ARG A 167
 None
 1.07A 2vxaA-5nz7A:
undetectable
2vxaK-5nz7A:
undetectable
2vxaL-5nz7A:
undetectable		 2vxaA-5nz7A:
5.46
2vxaK-5nz7A:
5.46
2vxaL-5nz7A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 171
ILE A 248
THR A 232
GLN A 200
 None
 1.02A 2xrhA-5nz7A:
undetectable		 2xrhA-5nz7A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 456
PHE A 457
GLY A 454
ASN A 452
PHE A 483
 None
 1.35A 2zznB-5nz7A:
undetectable		 2zznB-5nz7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 628
LEU A 792
TYR A 723
THR A 729
 None
 1.02A 3ag4N-5nz7A:
undetectable
3ag4W-5nz7A:
undetectable		 3ag4N-5nz7A:
18.92
3ag4W-5nz7A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 233
LYS A 226
HIS A 450
 None
 0.93A 3elzA-5nz7A:
1.6		 3elzA-5nz7A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A 750
SER A 752
PHE A 753
ILE A 774
 None
 0.99A 3ko0B-5nz7A:
undetectable		 3ko0B-5nz7A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 MET A 770
PHE A 714
ILE A 705
ALA A 709
ALA A 733
 None
 1.21A 3pcqB-5nz7A:
undetectable		 3pcqB-5nz7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A 200
TYR A 212
PHE A 211
TYR A 236
 None
 1.33A 3po7A-5nz7A:
undetectable		 3po7A-5nz7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 361
GLY A 363
THR A 364
LEU A 365
GLY A 370
 None
 1.10A 3sglA-5nz7A:
undetectable		 3sglA-5nz7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLN A  20
GLU A  93
LYS A  21
 None
 1.14A 3su9A-5nz7A:
undetectable		 3su9A-5nz7A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 LYS A 548
PRO A 550
LEU A 552
ASN A 542
 None
 1.20A 3tpxC-5nz7A:
0.0		 3tpxC-5nz7A:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 628
LEU A 792
TYR A 723
THR A 729
 None
 1.06A 3wg7A-5nz7A:
undetectable
3wg7J-5nz7A:
undetectable		 3wg7A-5nz7A:
18.92
3wg7J-5nz7A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLY A  23
ASN A  19
LEU A  28
ASN A  27
 None
 0.90A 3zqtA-5nz7A:
undetectable		 3zqtA-5nz7A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLU A 922
PHE A 459
TYR A 847
VAL A 853
 None
 1.09A 4a97E-5nz7A:
2.7		 4a97E-5nz7A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 340
PHE A 201
LEU A 278
VAL A 400
THR A 404
 None
 1.19A 4kyaB-5nz7A:
undetectable		 4kyaB-5nz7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 203
GLY A 389
CYH A 372
ASN A 373
ALA A 390
 None
 1.14A 4pclA-5nz7A:
undetectable		 4pclA-5nz7A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 718
SER A 659
ASP A 618
GLY A 610
LYS A 638
 None
 1.44A 4pevA-5nz7A:
undetectable		 4pevA-5nz7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A 281
THR A 283
THR A 364
HIS A 367
 None
 1.08A 4pgfA-5nz7A:
undetectable		 4pgfA-5nz7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 THR A 281
THR A 283
THR A 364
HIS A 367
 None
 1.08A 4pgfB-5nz7A:
undetectable		 4pgfB-5nz7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 628
LEU A 792
TYR A 723
THR A 729
 None
 1.03A 5b1aN-5nz7A:
undetectable
5b1aW-5nz7A:
undetectable		 5b1aN-5nz7A:
18.92
5b1aW-5nz7A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 489
PHE A 449
ILE A 516
TYR A 453
THR A 156
 CL  A1001 ( 3.8A)
None
None
None
None
 1.22A 5eslA-5nz7A:
undetectable		 5eslA-5nz7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 838
ALA A 829
ILE A 845
ALA A 846
ILE A 774
 None
 0.92A 5eypB-5nz7A:
1.8		 5eypB-5nz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 621
VAL A 609
GLY A 610
ARG A 656
 None
 0.99A 5nzyA-5nz7A:
undetectable		 5nzyA-5nz7A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 234
ILE A 210
LEU A 203
PHE A 201
 None
 0.95A 5vkqA-5nz7A:
undetectable
5vkqB-5nz7A:
undetectable		 5vkqA-5nz7A:
20.51
5vkqB-5nz7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 234
ILE A 210
LEU A 203
PHE A 201
 None
 0.93A 5vkqA-5nz7A:
undetectable
5vkqD-5nz7A:
undetectable		 5vkqA-5nz7A:
20.51
5vkqD-5nz7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 838
ALA A 829
ILE A 845
ALA A 846
ILE A 774
 None
 0.96A 5xiwB-5nz7A:
2.2		 5xiwB-5nz7A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ILE A 607
ILE A 705
ALA A 668
LEU A 671
ALA A 674
 None
 1.43A 5zjiB-5nz7A:
undetectable		 5zjiB-5nz7A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nz7 CELLODEXTRIN
PHOSPHORYLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 GLN A 864
THR A 880
THR A 873
HIS A 140
 None
None
None
CL  A1001 (-4.5A)
 1.20A 6aphA-5nz7A:
undetectable		 6aphA-5nz7A:
18.95