SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 4 VAL A  34
ALA A  26
LEU A  69
PHE A 105
 None
 1.17A 1q97B-5nzbA:
undetectable		 1q97B-5nzbA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ALA A 102
PHE A 105
LEU A  69
ILE A  49
THR A  99
 None
 1.13A 1rb2B-5nzbA:
undetectable		 1rb2B-5nzbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 6 LEU A  11
ALA A  36
SER A  38
SER A  40
 None
 1.06A 1tz8C-5nzbA:
undetectable
1tz8D-5nzbA:
undetectable		 1tz8C-5nzbA:
22.46
1tz8D-5nzbA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ILE A  27
ALA A 102
GLN A 101
LEU A 128
VAL A   7
 None
 1.09A 1xdkA-5nzbA:
undetectable		 1xdkA-5nzbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ILE A  27
ALA A 102
GLN A 101
LEU A 128
VAL A   7
 None
 1.00A 1xiuA-5nzbA:
undetectable		 1xiuA-5nzbA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 5 LEU A  62
VAL A 120
LEU A 124
MET A  53
 None
 1.00A 2oiqA-5nzbA:
undetectable		 2oiqA-5nzbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ILE A  27
ALA A 102
GLN A 101
LEU A 128
VAL A   7
 None
 1.03A 3dzyA-5nzbA:
undetectable		 3dzyA-5nzbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 8 GLY A 100
ILE A  27
ASP A  31
SER A  33
 None
 0.80A 3pwwA-5nzbA:
undetectable		 3pwwA-5nzbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 11 LEU A 103
GLU A  48
LEU A  67
PRO A  42
PHE A  41
 None
 1.19A 3ua5A-5nzbA:
undetectable		 3ua5A-5nzbA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ILE A 107
ALA A  26
ILE A  85
LEU A  67
ILE A  94
 None
 1.10A 4kjkA-5nzbA:
undetectable		 4kjkA-5nzbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 5 VAL A 120
GLU A 122
VAL A 104
LYS A  97
 None
 1.24A 4p6vB-5nzbA:
undetectable
4p6vE-5nzbA:
undetectable		 4p6vB-5nzbA:
15.38
4p6vE-5nzbA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ILE A 107
ALA A  26
ILE A  85
LEU A  67
ILE A  94
 None
 1.05A 4pthA-5nzbA:
undetectable		 4pthA-5nzbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ILE A  27
THR A  99
GLY A 125
GLY A  82
PHE A 105
 None
 1.14A 5d4uA-5nzbA:
undetectable		 5d4uA-5nzbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5nzb PROFILIN-2
(Betula
pendula) 		5 / 12 ALA A  24
LEU A  22
ALA A  26
PHE A 105
GLY A 106
 None
 1.26A 5jglA-5nzbA:
undetectable		 5jglA-5nzbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 8 ILE A  49
PHE A 105
PRO A  59
PHE A  56
 None
 1.08A 5x23A-5nzbA:
undetectable		 5x23A-5nzbA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5nzb PROFILIN-2
(Betula
pendula) 		4 / 6 GLU A  48
LYS A  45
PHE A  44
PRO A  42
 None
 1.09A 6fgdA-5nzbA:
undetectable		 6fgdA-5nzbA:
15.55