SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 THR A 307
LEU A 259
ILE A 194
LEU A 310
LEU A  58
 None
 1.19A 1errB-5nzgA:
undetectable		 1errB-5nzgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.25A 1mj2A-5nzgA:
undetectable		 1mj2A-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.29A 1mj2C-5nzgA:
undetectable		 1mj2C-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.31A 1mjoA-5nzgA:
undetectable		 1mjoA-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.28A 1mjoB-5nzgA:
undetectable		 1mjoB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.30A 1mjoC-5nzgA:
undetectable		 1mjoC-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 0.94A 1pxxA-5nzgA:
undetectable		 1pxxA-5nzgA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.27A 1pxxC-5nzgA:
undetectable		 1pxxC-5nzgA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 ILE A 360
ALA A 361
ALA A 359
LEU A 330
VAL A 246
LEU A 310
 None
 1.47A 1xlsB-5nzgA:
undetectable		 1xlsB-5nzgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 THR A 461
GLU A 251
HIS A 410
 None
EDO  A 609 (-4.8A)
EDO  A 609 (-3.1A)
 0.91A 1xwfB-5nzgA:
undetectable		 1xwfB-5nzgA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 THR A 461
GLU A 251
HIS A 410
 None
EDO  A 609 (-4.8A)
EDO  A 609 (-3.1A)
 0.90A 1xwfC-5nzgA:
undetectable		 1xwfC-5nzgA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 THR A 461
GLU A 251
HIS A 410
 None
EDO  A 609 (-4.8A)
EDO  A 609 (-3.1A)
 0.88A 1xwfD-5nzgA:
undetectable		 1xwfD-5nzgA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 GLN A  74
HIS A 124
ARG A 118
 None
 1.06A 1zlqA-5nzgA:
undetectable		 1zlqA-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 ASP A 108
PHE A 142
LEU A 143
ARG A 146
THR A  96
 None
 1.27A 2b8jB-5nzgA:
1.6		 2b8jB-5nzgA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 ALA A 486
ILE A 475
LEU A 458
LEU A 430
THR A 484
 None
 1.10A 2w3vA-5nzgA:
undetectable		 2w3vA-5nzgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 7 ILE A 194
LEU A 198
MET A 321
THR A 320
 None
 1.12A 2zxwN-5nzgA:
undetectable
2zxwW-5nzgA:
undetectable		 2zxwN-5nzgA:
undetectable
2zxwW-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 MET A 215
ILE A 312
LEU A 314
ILE A 194
LEU A 328
 None
 1.12A 3a50D-5nzgA:
undetectable		 3a50D-5nzgA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 VAL A 414
VAL A 413
ARG A 443
ARG A 249
 None
EDO  A 609 (-3.7A)
None
None
 1.24A 3bjwF-5nzgA:
undetectable		 3bjwF-5nzgA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 5 LEU A 314
LYS A 203
GLN A 205
LEU A 207
 None
None
EDO  A 605 (-2.9A)
None
 1.14A 3h5gA-5nzgA:
undetectable
3h5gB-5nzgA:
undetectable		 3h5gA-5nzgA:
undetectable
3h5gB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 VAL A 371
VAL A 231
TRP A 311
PHE A 216
 None
 1.43A 3jx4A-5nzgA:
undetectable
3jx4B-5nzgA:
undetectable		 3jx4A-5nzgA:
11.16
3jx4B-5nzgA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 TYR A 212
GLU A 157
SER A 122
ILE A 227
 EDO  A 603 (-3.8A)
None
None
None
 1.07A 3jz0B-5nzgA:
undetectable		 3jz0B-5nzgA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 VAL A 371
VAL A 231
TRP A 311
PHE A 216
 None
 1.42A 3n61A-5nzgA:
undetectable
3n61B-5nzgA:
undetectable		 3n61A-5nzgA:
11.16
3n61B-5nzgA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.03A 3nt1A-5nzgA:
undetectable		 3nt1A-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.03A 3nt1B-5nzgA:
undetectable		 3nt1B-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.00A 3rr3A-5nzgA:
undetectable		 3rr3A-5nzgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 0.99A 3rr3B-5nzgA:
undetectable		 3rr3B-5nzgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 ILE A 194
LEU A 198
MET A 321
THR A 320
 None
 1.19A 3wg7A-5nzgA:
undetectable
3wg7J-5nzgA:
undetectable		 3wg7A-5nzgA:
undetectable
3wg7J-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 5 PHE A 242
LEU A 330
GLY A 192
VAL A 217
 None
 0.90A 3wrkD-5nzgA:
undetectable		 3wrkD-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 ILE A 240
ILE A 194
LEU A  81
GLY A 357
ASN A 306
 None
None
UPG  A 601 (-3.6A)
None
UPG  A 601 (-3.7A)
 1.01A 4o1eB-5nzgA:
undetectable		 4o1eB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.26A 4rrwA-5nzgA:
undetectable		 4rrwA-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.27A 4rrwB-5nzgA:
undetectable		 4rrwB-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.26A 4rrwC-5nzgA:
undetectable		 4rrwC-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.27A 4rrwD-5nzgA:
undetectable		 4rrwD-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.26A 4rrzA-5nzgA:
undetectable		 4rrzA-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.27A 4rrzB-5nzgA:
undetectable		 4rrzB-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.26A 4rrzC-5nzgA:
undetectable		 4rrzC-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.27A 4rrzD-5nzgA:
undetectable		 4rrzD-5nzgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 VAL A 371
VAL A 231
TRP A 311
PHE A 216
 None
 1.42A 5addA-5nzgA:
undetectable
5addB-5nzgA:
undetectable		 5addA-5nzgA:
11.16
5addB-5nzgA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 VAL A 371
VAL A 231
TRP A 311
PHE A 216
 None
 1.46A 5adeA-5nzgA:
undetectable
5adeB-5nzgA:
undetectable		 5adeA-5nzgA:
11.16
5adeB-5nzgA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 326
ALA A  27
ALA A 197
LYS A 203
LEU A 204
 None
None
None
None
EDO  A 605 (-3.6A)
 0.92A 5bw4B-5nzgA:
undetectable		 5bw4B-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 ARG A 146
THR A 105
ASP A 108
 None
 0.82A 5g5gA-5nzgA:
undetectable
5g5gB-5nzgA:
undetectable		 5g5gA-5nzgA:
undetectable
5g5gB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 SER A  57
TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 1.25A 5ikrA-5nzgA:
undetectable		 5ikrA-5nzgA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 TYR A 234
VAL A 370
ALA A 368
SER A 367
LEU A 280
 None
 0.95A 5ikrB-5nzgA:
undetectable		 5ikrB-5nzgA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 ILE A 360
ALA A 361
ALA A 359
LEU A 330
VAL A 246
LEU A 310
 None
 1.47A 5z12B-5nzgA:
undetectable		 5z12B-5nzgA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 GLN A 287
GLU A 353
HIS A 191
ALA A 355
 None
None
UPG  A 601 (-3.8A)
UPG  A 601 ( 4.2A)
 1.42A 6f6jC-5nzgA:
undetectable
6f6jD-5nzgA:
undetectable		 6f6jC-5nzgA:
undetectable
6f6jD-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 5 GLY A  84
LEU A  85
SER A 132
GLN A 162
 UPG  A 601 (-3.2A)
None
None
UPG  A 601 (-3.3A)
 1.21A 6ji6A-5nzgA:
undetectable		 6ji6A-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 4 ASP A 171
ILE A 168
PRO A 175
LEU A 169
 EDO  A 606 ( 4.2A)
None
None
EDO  A 606 ( 3.3A)
 1.41A 6mkeA-5nzgA:
undetectable		 6mkeA-5nzgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 ILE A 194
LEU A 198
MET A 321
THR A 320
 None
 1.13A 6nmfN-5nzgA:
undetectable
6nmfW-5nzgA:
undetectable		 6nmfN-5nzgA:
undetectable
6nmfW-5nzgA:
undetectable