SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5nzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 300
ALA A 299
PHE A 351
GLY A 301
 None
 1.41A 1mjoB-5nzzA:
undetectable		 1mjoB-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ARG A 104
GLU A 269
PRO A 270
ALA A 181
 None
 1.13A 2ejfB-5nzzA:
undetectable		 2ejfB-5nzzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 104
GLU A 269
PRO A 270
ALA A 181
 None
 1.17A 2ejgA-5nzzA:
undetectable		 2ejgA-5nzzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 185
ASN A 186
GLU A 290
 None
 0.75A 3v4tA-5nzzA:
undetectable
3v4tC-5nzzA:
undetectable		 3v4tA-5nzzA:
undetectable
3v4tC-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.86A 4d33A-5nzzA:
undetectable		 4d33A-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.81A 4d33B-5nzzA:
undetectable		 4d33B-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.79A 4d39A-5nzzA:
undetectable		 4d39A-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.79A 4d39B-5nzzA:
undetectable		 4d39B-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 250
TYR A 246
VAL A  76
SER A 163
GLY A 165
 None
 1.30A 4mm6A-5nzzA:
2.9		 4mm6A-5nzzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 322
LEU A 323
ASP A 324
LEU A 369
 None
 0.82A 4wozA-5nzzA:
undetectable
4wozB-5nzzA:
undetectable		 4wozA-5nzzA:
undetectable
4wozB-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 110
ALA A 188
GLY A 184
GLU A 269
LEU A 107
 None
 1.03A 5ul4A-5nzzA:
undetectable		 5ul4A-5nzzA:
undetectable