SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		5 / 10 ILE A  77
ASN A  11
LEU A   9
VAL A  37
ILE A  62
 None
 1.18A 2nnhB-5o00A:
undetectable		 2nnhB-5o00A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		4 / 6 LEU A  78
ILE A 168
MET A  23
VAL A 185
 None
 1.19A 2ygoA-5o00A:
undetectable		 2ygoA-5o00A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		3 / 3 PHE A 173
ASN A 177
PHE A 117
 None
 0.80A 2zbuD-5o00A:
undetectable		 2zbuD-5o00A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		5 / 11 MET A  23
ARG A 210
ILE A 208
VAL A 174
ILE A 171
 None
None
GOL  A 309 ( 3.7A)
None
None
 1.26A 3rf4A-5o00A:
undetectable
3rf4C-5o00A:
undetectable		 3rf4A-5o00A:
18.06
3rf4C-5o00A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		5 / 11 ILE A 171
MET A  23
ARG A 210
ILE A 208
VAL A 174
 None
None
None
GOL  A 309 ( 3.7A)
None
 1.28A 3rf4A-5o00A:
undetectable
3rf4B-5o00A:
undetectable		 3rf4A-5o00A:
18.06
3rf4B-5o00A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		5 / 11 ILE A 171
MET A  23
ARG A 210
ILE A 208
VAL A 174
 None
None
None
GOL  A 309 ( 3.7A)
None
 1.28A 3rf4B-5o00A:
undetectable
3rf4C-5o00A:
undetectable		 3rf4B-5o00A:
18.06
3rf4C-5o00A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		4 / 7 PHE A  32
ARG A  26
ASP A  22
TYR A  36
 None
SO4  A 305 (-2.9A)
None
None
 1.02A 5a06F-5o00A:
undetectable		 5a06F-5o00A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5o00 GLUTATHIONE
TRANSFERASE URE2P5
(Phanerochaete
chrysosporium) 		4 / 4 LEU A  79
LEU A 106
SER A  92
ALA A 169
 None
 1.13A 5uunA-5o00A:
22.3		 5uunA-5o00A:
25.94