SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_A_MTXA2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	5o05	NANOBODY (VHH) NANO-42 (Vicugna pacos)	5 / 12	VAL C 2 ALA C 24 SER C 29 ASN C 76 VAL C 78	None	0.82A	3qxtA-5o05C: 17.3	3qxtA-5o05C: 66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	5o05	NANOBODY (VHH) NANO-42 (Vicugna pacos)	6 / 12	VAL C 2 LEU C 4 ALA C 24 SER C 29 VAL C 78 TYR C 109	None	0.81A	3qxtB-5o05C: 17.1	3qxtB-5o05C: 66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_D_MTXD2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5o05	NANOBODY (VHH) NANO-42 (Vicugna pacos)	5 / 12	VAL C 2 ALA C 24 SER C 29 VAL C 78 TYR C 109	None	0.90A	3qxvD-5o05C: 17.1	3qxvD-5o05C: 67.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_D_MIYD392_1 (TETX2 PROTEIN)	5o05	NANOBODY (VHH) NANO-42 (Vicugna pacos)	4 / 5	SER C 27 GLN C 3 SER C 25 VAL C 28	EDO C 201 (-3.4A) None None None	1.45A	4a99D-5o05C: undetectable	4a99D-5o05C: 14.36