SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ALA A 204
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.73A 1bx4A-5o0jA:
23.5
1bx4A-5o0jA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
LEU A  93
GLY A 114
GLY A 115
ALA A 204
GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
0.59A 1bx4A-5o0jA:
23.5
1bx4A-5o0jA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 6 GLN A 116
ASP A 443
VAL A 439
GLY A 114
GLC  A 503 (-3.0A)
GLC  A 503 (-2.6A)
GLC  A 503 ( 4.8A)
GLC  A 503 (-3.5A)
1.28A 1ekjC-5o0jA:
undetectable
1ekjD-5o0jA:
undetectable
1ekjC-5o0jA:
undetectable
1ekjD-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 6 ASP A 443
VAL A 439
GLY A 114
GLN A 116
GLC  A 503 (-2.6A)
GLC  A 503 ( 4.8A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.0A)
1.28A 1ekjC-5o0jA:
undetectable
1ekjD-5o0jA:
undetectable
1ekjC-5o0jA:
undetectable
1ekjD-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 9 VAL A 292
VAL A 302
LEU A 333
ILE A 282
LEU A 294
None
1.17A 1eqgA-5o0jA:
undetectable
1eqgA-5o0jA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ILE A 249
LEU A 256
LEU A 237
ILE A 234
PHE A 270
None
1.14A 1fmlB-5o0jA:
undetectable
1fmlB-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 6 ASN A  33
ASN A  35
ILE A 119
GLY A 114
GLC  A 503 (-4.3A)
GLC  A 503 (-3.4A)
None
GLC  A 503 (-3.5A)
0.84A 1oniA-5o0jA:
undetectable
1oniB-5o0jA:
0.3
1oniA-5o0jA:
undetectable
1oniB-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 6 ASN A  33
ASN A  35
ILE A 119
GLY A 114
GLC  A 503 (-4.3A)
GLC  A 503 (-3.4A)
None
GLC  A 503 (-3.5A)
0.90A 1oniD-5o0jA:
undetectable
1oniF-5o0jA:
undetectable
1oniD-5o0jA:
undetectable
1oniF-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 6 ARG A 168
ASP A 176
ASP A 206
ASN A 209
None
1.30A 1rjdB-5o0jA:
undetectable
1rjdB-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ILE A 225
PHE A 222
SER A 235
ILE A 234
LEU A 259
None
1.10A 1rx3A-5o0jA:
undetectable
1rx3A-5o0jA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 8 GLU A 298
VAL A 297
ARG A 341
HIS A 267
8BR  A 501 ( 4.6A)
8BR  A 502 ( 4.5A)
None
None
1.29A 1s3zA-5o0jA:
undetectable
1s3zB-5o0jA:
undetectable
1s3zA-5o0jA:
undetectable
1s3zB-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
None
1.16A 1ya3C-5o0jA:
undetectable
1ya3C-5o0jA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.34A 2pkkA-5o0jA:
19.3
2pkkA-5o0jA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.35A 2pkmA-5o0jA:
undetectable
2pkmA-5o0jA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
None
1.21A 2w8yB-5o0jA:
undetectable
2w8yB-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
ASN A 260
LEU A 262
GLY A 263
ARG A  26
None
1.41A 2yhdA-5o0jA:
undetectable
2yhdA-5o0jA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ALA A 271
GLU A 298
MET A 120
ILE A 119
GLY A 115
None
8BR  A 501 ( 4.6A)
None
None
GLC  A 503 (-3.7A)
1.13A 2yjaB-5o0jA:
undetectable
2yjaB-5o0jA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
3 / 3 SER A 446
GLU A 296
ASP A 319
None
8BR  A 501 ( 4.7A)
None
0.66A 2zulA-5o0jA:
4.1
2zulA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
None
1.20A 3d90A-5o0jA:
undetectable
3d90A-5o0jA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
None
1.31A 3d90B-5o0jA:
undetectable
3d90B-5o0jA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
3 / 3 SER A 446
GLU A 296
ASP A 319
None
8BR  A 501 ( 4.7A)
None
0.70A 3dmhA-5o0jA:
3.6
3dmhA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 8 VAL A  25
VAL A  18
TYR A 128
VAL A  28
None
0.73A 3fhxB-5o0jA:
14.6
3fhxB-5o0jA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 10 ALA A 205
VAL A  99
ILE A  80
LEU A  77
ILE A  70
None
1.17A 3jw3A-5o0jA:
undetectable
3jw3A-5o0jA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 9 ALA A 205
VAL A  99
ILE A  80
LEU A  77
ILE A  70
None
1.21A 3jw3B-5o0jA:
undetectable
3jw3B-5o0jA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
3 / 3 VAL A 190
VAL A  59
SER A  63
None
0.66A 3n8xB-5o0jA:
0.7
3n8xB-5o0jA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 4 ASP A  16
GLU A  12
GLU A  19
ARG A 388
None
1.39A 3o0mA-5o0jA:
undetectable
3o0mA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 11 ILE A 225
PHE A 222
SER A 235
ILE A 234
LEU A  29
None
1.26A 3qg2B-5o0jA:
undetectable
3qg2B-5o0jA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
3 / 3 ARG A 200
PRO A 196
PHE A 184
8BR  A 501 (-3.2A)
None
None
0.72A 3thrC-5o0jA:
undetectable
3thrC-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
6 / 12 ASP A  37
GLY A 114
GLY A 115
ARG A 200
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
8BR  A 501 (-3.2A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.63A 3uboA-5o0jA:
24.2
3uboA-5o0jA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.47A 3uq6A-5o0jA:
24.0
3uq6A-5o0jA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.51A 3vaqA-5o0jA:
23.9
3vaqA-5o0jA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.49A 3vasA-5o0jA:
23.9
3vasA-5o0jA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.52A 3vasB-5o0jA:
23.3
3vasB-5o0jA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.47A 4dc3B-5o0jA:
24.0
4dc3B-5o0jA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.39A 4e3aB-5o0jA:
24.5
4e3aB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
None
1.21A 4fn9B-5o0jA:
undetectable
4fn9B-5o0jA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.46A 4jksA-5o0jA:
24.5
4jksA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.46A 4jksB-5o0jA:
24.4
4jksB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.46A 4jkuA-5o0jA:
24.5
4jkuA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.45A 4k8cA-5o0jA:
24.4
4k8cA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.45A 4k8cB-5o0jA:
24.5
4k8cB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.47A 4k8kA-5o0jA:
24.5
4k8kA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.47A 4k8kB-5o0jA:
24.5
4k8kB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.45A 4kahA-5o0jA:
24.6
4kahA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.45A 4kahB-5o0jA:
24.5
4kahB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.47A 4kalA-5o0jA:
24.5
4kalA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.47A 4kalB-5o0jA:
24.5
4kalB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.45A 4kanA-5o0jA:
24.6
4kanA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.44A 4kanB-5o0jA:
24.4
4kanB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.45A 4kbeA-5o0jA:
24.6
4kbeA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.44A 4kbeB-5o0jA:
24.5
4kbeB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.46A 4lbgA-5o0jA:
24.5
4lbgA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.46A 4lbgB-5o0jA:
24.5
4lbgB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.44A 4lcaA-5o0jA:
24.5
4lcaA-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ILE A 181
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.44A 4lcaB-5o0jA:
24.5
4lcaB-5o0jA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
None
1.16A 4ltwA-5o0jA:
undetectable
4ltwA-5o0jA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 115
ALA A 204
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.7A)
None
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.96A 4n09A-5o0jA:
24.1
4n09A-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
LEU A  93
GLY A 115
ALA A 204
GLY A 440
GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.7A)
None
GLC  A 503 ( 4.1A)
1.15A 4n09A-5o0jA:
24.1
4n09A-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ALA A 204
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.79A 4n09B-5o0jA:
22.7
4n09B-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
LEU A  93
GLY A 114
GLY A 115
ALA A 204
GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
0.59A 4n09B-5o0jA:
22.7
4n09B-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
LEU A  93
GLY A 114
GLY A 115
ALA A 204
GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
0.60A 4n09C-5o0jA:
24.2
4n09C-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
ALA A 204
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
0.79A 4n09D-5o0jA:
23.9
4n09D-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
LEU A  93
GLY A 114
GLY A 115
ALA A 204
GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
0.59A 4n09D-5o0jA:
23.9
4n09D-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A 363
ILE A 445
SER A 446
HIS A 343
LEU A 370
None
1.36A 4pooA-5o0jA:
undetectable
4pooA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 5 PHE A 147
HIS A 135
LEU A  30
PRO A 167
None
1.34A 5csyB-5o0jA:
undetectable
5csyB-5o0jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ALA A 271
GLU A 298
MET A 120
ILE A 119
GLY A 115
None
8BR  A 501 ( 4.6A)
None
None
GLC  A 503 (-3.7A)
1.11A 5gs4A-5o0jA:
undetectable
5gs4A-5o0jA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 TYR A 347
THR A 438
ILE A 441
GLY A 442
ILE A 445
8BR  A 501 (-4.3A)
8BR  A 501 ( 4.3A)
8BR  A 501 (-3.4A)
8BR  A 501 ( 3.9A)
None
0.71A 5ifuA-5o0jA:
2.7
5ifuA-5o0jA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A  37
GLY A 114
GLY A 115
GLY A 440
ASP A 443
GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
0.42A 5kb5A-5o0jA:
24.5
5kb5A-5o0jA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 8 ARG A 215
TRP A 218
GLU A 217
PRO A 155
None
1.14A 5kgpB-5o0jA:
undetectable
5kgpB-5o0jA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ASP A 363
GLU A 453
LEU A 406
LEU A 351
ALA A 352
None
1.16A 5nd7B-5o0jA:
4.2
5nd7B-5o0jA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 GLY A 236
ASP A 443
GLY A 114
ASN A  35
ILE A 119
None
GLC  A 503 (-2.6A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.4A)
None
0.85A 5vopA-5o0jA:
3.3
5vopA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 ALA A 232
PHE A 289
LEU A  29
GLY A 236
LEU A 285
None
1.05A 5x24A-5o0jA:
undetectable
5x24A-5o0jA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 SER A  21
LEU A 384
VAL A 127
GLY A 129
PHE A 367
None
1.14A 6a94A-5o0jA:
undetectable
6a94A-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
5 / 12 SER A  21
LEU A 384
VAL A 127
GLY A 129
PHE A 367
None
1.14A 6a94B-5o0jA:
undetectable
6a94B-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii)
4 / 4 ARG A 171
GLU A 174
GLU A 217
ARG A 215
None
1.32A 6fk2A-5o0jA:
undetectable
6fk2A-5o0jA:
undetectable