SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 GLY A 317
THR A 286
THR A 285
THR A 311
 None
 0.84A 1c9sT-5o0sA:
undetectable
1c9sU-5o0sA:
undetectable		 1c9sT-5o0sA:
6.51
1c9sU-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 GLY A 317
THR A 286
THR A 285
THR A 311
 None
 0.83A 1gtfL-5o0sA:
undetectable
1gtfM-5o0sA:
undetectable		 1gtfL-5o0sA:
6.51
1gtfM-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 GLY A 317
THR A 286
THR A 285
THR A 311
 None
 0.82A 1gtfN-5o0sA:
undetectable
1gtfO-5o0sA:
undetectable		 1gtfN-5o0sA:
6.51
1gtfO-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 6 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.88A 1gtnD-5o0sA:
undetectable
1gtnE-5o0sA:
undetectable		 1gtnD-5o0sA:
6.51
1gtnE-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.88A 1gtnF-5o0sA:
undetectable
1gtnG-5o0sA:
undetectable		 1gtnF-5o0sA:
6.51
1gtnG-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.89A 1gtnJ-5o0sA:
undetectable
1gtnK-5o0sA:
undetectable		 1gtnJ-5o0sA:
6.51
1gtnK-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 VAL A 113
SER A 210
ASN A 323
ASP A 208
 None
 1.29A 1hwiC-5o0sA:
undetectable		 1hwiC-5o0sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 VAL A 113
SER A 210
ASN A 323
ASP A 208
 None
 1.29A 1hwiD-5o0sA:
undetectable		 1hwiD-5o0sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 11 TRP A 340
GLU A 264
GLY A 365
VAL A 192
PRO A 191
 None
EDO  A 902 (-3.1A)
None
None
None
 1.29A 1i9jH-5o0sA:
2.4
1i9jL-5o0sA:
2.3		 1i9jH-5o0sA:
14.36
1i9jL-5o0sA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 6 TRP A 595
ASP A 655
SER A 601
SER A 663
 None
 1.34A 1kiaC-5o0sA:
0.5		 1kiaC-5o0sA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 6 ASN A 578
ASP A 579
GLY A 580
PRO A 582
 None
CA  A 910 (-2.8A)
None
None
 0.92A 1n4fA-5o0sA:
undetectable		 1n4fA-5o0sA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 LEU A 451
GLU A 777
VAL A 735
TYR A 456
LEU A 607
 None
9FQ  A 911 (-3.6A)
None
None
None
 1.22A 1s9pB-5o0sA:
undetectable		 1s9pB-5o0sA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 ILE A 211
ILE A 332
VAL A 272
LEU A 376
PHE A 336
 None
 1.12A 1xozA-5o0sA:
undetectable		 1xozA-5o0sA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 PHE A  91
GLN A 176
TYR A 161
TYR A 163
 None
 1.46A 2aoxA-5o0sA:
undetectable		 2aoxA-5o0sA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 PHE A 213
GLN A 176
TYR A 161
TYR A 163
 None
 1.34A 2aoxA-5o0sA:
undetectable		 2aoxA-5o0sA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 SER A 112
ALA A 319
PHE A 213
LEU A 338
 None
 0.83A 2bxmA-5o0sA:
2.4		 2bxmA-5o0sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 4 SER A 512
GLY A  99
HIS A 507
ASP A 593
 None
None
9FQ  A 911 (-3.9A)
9FQ  A 911 (-3.5A)
 1.35A 2oxtC-5o0sA:
undetectable		 2oxtC-5o0sA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 9 ILE A 468
GLY A 418
TYR A 448
GLU A 449
ARG A 454
 None
 1.07A 2pivA-5o0sA:
undetectable		 2pivA-5o0sA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 10 ILE A 468
GLY A 417
TYR A 448
GLU A 449
ARG A 454
 None
 1.46A 2piwA-5o0sA:
undetectable		 2piwA-5o0sA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 10 ILE A 468
GLY A 418
TYR A 448
GLU A 449
ARG A 454
 None
 1.05A 2piwA-5o0sA:
undetectable		 2piwA-5o0sA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 TYR A 603
THR A 594
ASP A 593
HIS A 660
MET A 665
 None
None
9FQ  A 911 (-3.5A)
None
None
 1.30A 2qo4A-5o0sA:
undetectable		 2qo4A-5o0sA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 ILE A  33
ILE A 332
THR A 331
LEU A 326
VAL A 322
 None
 1.21A 2qo5A-5o0sA:
2.6		 2qo5A-5o0sA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 TYR A 603
THR A 594
ASP A 593
HIS A 660
MET A 665
 None
None
9FQ  A 911 (-3.5A)
None
None
 1.31A 2qo6A-5o0sA:
5.3		 2qo6A-5o0sA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 ILE A 344
PHE A 556
ALA A 477
THR A 479
LEU A 509
 None
 1.37A 2x2nD-5o0sA:
undetectable		 2x2nD-5o0sA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 TYR A 161
ILE A  48
PHE A 111
PHE A 213
SER A  92
 None
 1.31A 3apwA-5o0sA:
undetectable		 3apwA-5o0sA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 LEU A 607
LYS A 537
ASP A 667
ALA A 670
 None
 1.28A 3mbgA-5o0sA:
undetectable
3mbgB-5o0sA:
undetectable		 3mbgA-5o0sA:
9.25
3mbgB-5o0sA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 LEU A 292
ILE A 320
SER A 318
ALA A 125
VAL A 334
 None
 1.11A 3vw1D-5o0sA:
undetectable		 3vw1D-5o0sA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 5 GLU A 132
GLY A 131
TYR A 107
GLN A 110
 None
 1.33A 3w9tB-5o0sA:
undetectable		 3w9tB-5o0sA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 LEU A 693
ILE A 696
ALA A 738
ALA A 756
GLY A 758
 None
 0.82A 4enhA-5o0sA:
undetectable		 4enhA-5o0sA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASP A 589
ASP A 579
ASN A 584
ASP A 583
 None
CA  A 910 (-2.8A)
None
CA  A 910 (-3.2A)
 1.18A 4feuB-5o0sA:
undetectable		 4feuB-5o0sA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 ASP A 589
ASP A 579
ASN A 584
ASP A 583
 None
CA  A 910 (-2.8A)
None
CA  A 910 (-3.2A)
 1.19A 4feuF-5o0sA:
undetectable		 4feuF-5o0sA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASP A 589
ASP A 579
ASN A 584
ASP A 583
 None
CA  A 910 (-2.8A)
None
CA  A 910 (-3.2A)
 1.23A 4fevD-5o0sA:
undetectable		 4fevD-5o0sA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASP A 589
ASP A 579
ASN A 584
ASP A 583
 None
CA  A 910 (-2.8A)
None
CA  A 910 (-3.2A)
 1.22A 4fevF-5o0sA:
undetectable		 4fevF-5o0sA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 6 PHE A 195
PRO A 335
PHE A 336
PHE A 111
 None
 1.15A 4fgkA-5o0sA:
undetectable		 4fgkA-5o0sA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASP A 589
ASP A 579
ASN A 584
ASP A 583
 None
CA  A 910 (-2.8A)
None
CA  A 910 (-3.2A)
 1.22A 4gkhG-5o0sA:
undetectable		 4gkhG-5o0sA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 11 ASN A 409
ALA A  43
GLN A 390
PRO A 460
ILE A 796
 None
 1.28A 4j4vA-5o0sA:
undetectable		 4j4vA-5o0sA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 11 ASN A 409
ALA A  43
GLN A 390
PRO A 460
ILE A 796
 None
 1.26A 4j4vD-5o0sA:
undetectable
4j4vE-5o0sA:
undetectable		 4j4vD-5o0sA:
15.98
4j4vE-5o0sA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASP A 288
SER A 140
HIS A 294
SER A 290
 None
 1.09A 4k7gB-5o0sA:
undetectable		 4k7gB-5o0sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		3 / 3 ASP A 545
TRP A 673
SER A 458
 None
 0.98A 4lrhB-5o0sA:
undetectable		 4lrhB-5o0sA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 6 ASP A 765
ASN A  54
ALA A  55
TYR A  69
 None
 1.18A 4mdbA-5o0sA:
undetectable		 4mdbA-5o0sA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 ALA A 615
TYR A 543
PHE A 556
GLY A 619
THR A 560
 None
 1.24A 4mm4B-5o0sA:
undetectable		 4mm4B-5o0sA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 5 TYR A 790
ASP A 667
GLU A 730
VAL A 721
 None
 1.30A 4nkvA-5o0sA:
undetectable		 4nkvA-5o0sA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 5 TYR A 790
ASP A 667
GLU A 730
VAL A 721
 None
 1.32A 4nkvB-5o0sA:
undetectable		 4nkvB-5o0sA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB607_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 4 TYR A 456
TRP A 732
ARG A 792
TYR A 603
 None
9FQ  A 911 (-4.7A)
9FQ  A 911 (-3.6A)
None
 1.39A 4qn9A-5o0sA:
0.1
4qn9B-5o0sA:
0.1		 4qn9A-5o0sA:
18.59
4qn9B-5o0sA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 GLY A 365
ILE A 371
SER A 368
ILE A 344
TRP A 340
 None
None
EDO  A 902 (-3.6A)
None
None
 1.13A 4qtuB-5o0sA:
undetectable		 4qtuB-5o0sA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 9 ALA A 319
THR A 214
VAL A 247
GLY A 268
ALA A 249
 None
 1.09A 4qvnK-5o0sA:
undetectable
4qvnL-5o0sA:
undetectable		 4qvnK-5o0sA:
15.05
4qvnL-5o0sA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 9 ALA A 319
THR A 214
VAL A 247
GLY A 268
ALA A 249
 None
 1.09A 4qvnY-5o0sA:
undetectable
4qvnZ-5o0sA:
undetectable		 4qvnY-5o0sA:
15.05
4qvnZ-5o0sA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		3 / 3 THR A 311
ASN A 229
SER A 230
 None
 0.71A 4tvtA-5o0sA:
undetectable		 4tvtA-5o0sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		3 / 3 GLU A 118
LYS A 116
ASN A 206
 None
 0.90A 4y1dA-5o0sA:
undetectable
4y1dD-5o0sA:
undetectable		 4y1dA-5o0sA:
12.52
4y1dD-5o0sA:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASN A 158
LYS A 175
TYR A 161
TYR A 163
 None
 1.10A 4yv5A-5o0sA:
undetectable		 4yv5A-5o0sA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 ASN A 158
LYS A 175
TYR A 161
TYR A 163
 None
 1.06A 4yv5B-5o0sA:
undetectable		 4yv5B-5o0sA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 10 TYR A 523
ASN A 521
ASP A 508
LEU A 534
GLN A 590
 9FQ  A 911 (-4.0A)
None
None
None
None
 1.25A 4zp0A-5o0sA:
1.1		 4zp0A-5o0sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 LEU A 794
GLY A 457
TYR A 764
TYR A 412
LEU A 411
 None
 1.38A 5czyA-5o0sA:
undetectable		 5czyA-5o0sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5eevL-5o0sA:
undetectable
5eevV-5o0sA:
undetectable		 5eevL-5o0sA:
6.51
5eevV-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5eewL-5o0sA:
undetectable
5eewV-5o0sA:
undetectable		 5eewL-5o0sA:
6.51
5eewV-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5eezL-5o0sA:
undetectable
5eezV-5o0sA:
undetectable		 5eezL-5o0sA:
6.51
5eezV-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5ef1L-5o0sA:
undetectable
5ef1V-5o0sA:
undetectable		 5ef1L-5o0sA:
6.51
5ef1V-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5ef2L-5o0sA:
undetectable
5ef2V-5o0sA:
0.4		 5ef2L-5o0sA:
6.51
5ef2V-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.87A 5ef3L-5o0sA:
undetectable
5ef3V-5o0sA:
0.4		 5ef3L-5o0sA:
6.51
5ef3V-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 GLY A 503
ALA A 567
TYR A 538
LEU A 568
VAL A 539
 None
 1.21A 5hw4A-5o0sA:
undetectable		 5hw4A-5o0sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 GLY A 503
ALA A 567
TYR A 538
LEU A 568
VAL A 539
 None
 1.22A 5hw4C-5o0sA:
undetectable		 5hw4C-5o0sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 7 THR A 780
ASP A 782
TYR A 771
GLY A  56
 None
 1.09A 5hwaA-5o0sA:
undetectable		 5hwaA-5o0sA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 LEU A 411
TYR A 412
ALA A 406
GLY A 457
LEU A 439
 None
 0.93A 5kirA-5o0sA:
undetectable		 5kirA-5o0sA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 10 PRO A 793
LEU A 411
ILE A 180
PRO A 182
PHE A  78
 None
 1.43A 5m0oA-5o0sA:
undetectable		 5m0oA-5o0sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		4 / 8 ALA A 610
LEU A 568
ILE A 618
VAL A 542
 None
 0.84A 5nujA-5o0sA:
2.2		 5nujA-5o0sA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 VAL A 127
ALA A 249
PHE A 283
VAL A 106
LEU A 138
 None
 1.19A 5tudD-5o0sA:
undetectable		 5tudD-5o0sA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 GLN A 110
VAL A 106
TRP A  94
PHE A 111
LEU A  75
 None
 1.03A 5uc3B-5o0sA:
undetectable		 5uc3B-5o0sA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		5 / 12 TYR A 745
LEU A 540
LEU A 678
LEU A 680
ILE A 683
 None
 1.22A 5v0vA-5o0sA:
undetectable		 5v0vA-5o0sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		3 / 3 LYS A 373
ASN A 377
SER A 244
 None
 1.19A 5yw0A-5o0sA:
undetectable		 5yw0A-5o0sA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5o0s GLUCOSYLCERAMIDASE
(Thermoanaerobact
erium
xylanolyticum) 		3 / 3 GLN A 616
TYR A 635
ASN A 632
 None
 0.67A 6dwdC-5o0sA:
undetectable		 6dwdC-5o0sA:
20.92