SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		3 / 3 TRP A 378
ALA A 371
VAL A 347
 HEM  A 504 ( 3.3A)
None
None
 0.92A 1c4dC-5o0tA:
undetectable
1c4dD-5o0tA:
undetectable		 1c4dC-5o0tA:
12.04
1c4dD-5o0tA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 11 LEU A 250
HIS A 317
HIS A 313
ALA A 255
GLY A 259
 None
HEM  A 505 (-3.5A)
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
 1.06A 1cmaA-5o0tA:
undetectable
1cmaB-5o0tA:
undetectable		 1cmaA-5o0tA:
19.31
1cmaB-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
LEU A 250
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.5A)
 1.00A 1mj2A-5o0tA:
undetectable
1mj2B-5o0tA:
undetectable		 1mj2A-5o0tA:
19.31
1mj2B-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
LEU A 250
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.5A)
 1.00A 1mj2C-5o0tA:
undetectable
1mj2D-5o0tA:
undetectable		 1mj2C-5o0tA:
19.31
1mj2D-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
LEU A 250
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.5A)
 1.02A 1mjoC-5o0tA:
undetectable
1mjoD-5o0tA:
undetectable		 1mjoC-5o0tA:
19.31
1mjoD-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 11 LEU A 250
HIS A 317
HIS A 313
ALA A 255
GLY A 259
 None
HEM  A 505 (-3.5A)
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
 1.01A 1mjqA-5o0tA:
undetectable
1mjqB-5o0tA:
undetectable		 1mjqA-5o0tA:
19.31
1mjqB-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
ALA A 316
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
GOL  A 511 (-3.9A)
HEM  A 505 (-3.5A)
 0.76A 1mjqC-5o0tA:
undetectable
1mjqD-5o0tA:
undetectable		 1mjqC-5o0tA:
19.31
1mjqD-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
LEU A 250
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.5A)
 1.00A 1mjqC-5o0tA:
undetectable
1mjqD-5o0tA:
undetectable		 1mjqC-5o0tA:
19.31
1mjqD-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 11 LEU A 250
HIS A 317
HIS A 313
ALA A 255
GLY A 259
 None
HEM  A 505 (-3.5A)
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
 1.02A 1mjqI-5o0tA:
undetectable
1mjqJ-5o0tA:
undetectable		 1mjqI-5o0tA:
19.31
1mjqJ-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
ALA A 316
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
GOL  A 511 (-3.9A)
HEM  A 505 (-3.5A)
 0.76A 1mjqI-5o0tA:
undetectable
1mjqJ-5o0tA:
undetectable		 1mjqI-5o0tA:
19.31
1mjqJ-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 HIS A 313
ALA A 255
GLY A 259
LEU A 250
HIS A 317
 HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.5A)
 1.00A 1mjqI-5o0tA:
undetectable
1mjqJ-5o0tA:
undetectable		 1mjqI-5o0tA:
19.31
1mjqJ-5o0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		4 / 5 LEU A 264
TRP A 378
MET A 306
LEU A 309
 None
HEM  A 504 ( 3.3A)
HEM  A 504 ( 4.6A)
LFA  A 507 ( 4.8A)
 1.49A 1p93D-5o0tA:
undetectable		 1p93D-5o0tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		4 / 5 VAL A 302
GLY A 303
VAL A 305
TRP A 352
 None
HEM  A 504 (-3.6A)
LFA  A 507 ( 4.5A)
None
 1.30A 1tkqB-5o0tA:
undetectable		 1tkqB-5o0tA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 10 ASN A 320
HIS A 317
HIS A 313
VAL A 252
ALA A 337
 None
HEM  A 505 (-3.5A)
HEM  A 505 (-3.2A)
None
HEM  A 505 (-3.6A)
 1.43A 4yhaH-5o0tA:
undetectable		 4yhaH-5o0tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5o0t PUTATIVE FERRIC
REDUCTASE
(Cylindrospermum
stagnale) 		5 / 12 LEU A 250
ILE A 254
LEU A 262
GLY A 315
ALA A 308
 None
GOL  A 511 ( 4.4A)
HEM  A 505 ( 4.0A)
GOL  A 511 (-3.3A)
LFA  A 507 (-3.6A)
 1.28A 6qxsD-5o0tA:
undetectable		 6qxsD-5o0tA:
21.45