SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 8 LEU A 464
ALA A 479
VAL A 488
VAL A 543
 None
 0.82A 1epbB-5o0yA:
undetectable		 1epbB-5o0yA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 8 ASP A 536
SER A 539
TYR A 532
HIS A 508
 None
 1.37A 2v0gA-5o0yA:
undetectable		 2v0gA-5o0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		3 / 3 LEU A 556
TYR A 555
GLN A 558
 None
 0.67A 2wekA-5o0yA:
undetectable		 2wekA-5o0yA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		5 / 12 ASN A 576
ILE A 589
ASN A 660
SER A 617
HIS A 590
 None
 1.13A 3bwmA-5o0yA:
undetectable		 3bwmA-5o0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		5 / 10 LEU A 468
VAL A 476
LYS A 491
VAL A 527
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.66A 3cs9A-5o0yA:
20.9		 3cs9A-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 6 LEU A 468
VAL A 476
LYS A 491
ASP A 613
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
 0.61A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 6 VAL A 476
LYS A 491
LEU A 599
ASP A 613
 AGS  A 801 (-4.0A)
AGS  A 801 (-2.8A)
None
None
 0.80A 3cs9D-5o0yA:
20.1		 3cs9D-5o0yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 11 LEU A 468
VAL A 476
ALA A 489
TYR A 546
CYH A 547
GLY A 549
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.8A)
AGS  A 801 (-4.3A)
None
 0.61A 3g0fA-5o0yA:
20.9		 3g0fA-5o0yA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 10 LEU A 468
VAL A 476
ALA A 489
TYR A 546
CYH A 547
GLY A 549
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.8A)
AGS  A 801 (-4.3A)
None
 0.66A 3g0fB-5o0yA:
21.2		 3g0fB-5o0yA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		7 / 12 LEU A 468
GLY A 469
GLY A 471
VAL A 476
ALA A 489
LYS A 491
TYR A 546
 AGS  A 801 (-4.1A)
AGS  A 801 ( 4.0A)
AGS  A 801 (-3.5A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
AGS  A 801 ( 4.8A)
 0.50A 3lxnA-5o0yA:
23.8		 3lxnA-5o0yA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 8 VAL A 527
LEU A 599
ILE A 611
ASP A 613
 None
 0.62A 3wzeA-5o0yA:
20.6		 3wzeA-5o0yA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 6 VAL A 527
CYH A 547
LEU A 599
ILE A 611
 None
AGS  A 801 (-4.3A)
None
None
 0.87A 4asdA-5o0yA:
20.3		 4asdA-5o0yA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		4 / 8 PHE A 614
HIS A 518
GLU A 520
ILE A 588
 None
 1.00A 4cx7A-5o0yA:
undetectable
4cx7B-5o0yA:
undetectable		 4cx7A-5o0yA:
10.78
4cx7B-5o0yA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 11 VAL A 476
ALA A 489
LYS A 491
LEU A 544
ASP A 551
LEU A 599
 AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
AGS  A 801 ( 4.0A)
None
None
 0.75A 4iaaA-5o0yA:
25.3		 4iaaA-5o0yA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		7 / 12 LEU A 468
VAL A 476
ALA A 489
LYS A 491
VAL A 527
TYR A 546
THR A 612
 AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
None
AGS  A 801 ( 4.8A)
None
 0.77A 4mxxB-5o0yA:
14.4		 4mxxB-5o0yA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		3 / 3 PRO A 645
LEU A 644
GLN A 636
 None
 0.52A 4pevB-5o0yA:
undetectable		 4pevB-5o0yA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		5 / 12 ASN A 576
ILE A 589
ASN A 660
SER A 617
HIS A 590
 None
 1.14A 4xueA-5o0yA:
undetectable		 4xueA-5o0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2
(Homo
sapiens) 		6 / 11 LEU A 468
GLY A 469
VAL A 476
ALA A 489
LEU A 544
TYR A 546
 AGS  A 801 (-4.1A)
AGS  A 801 ( 4.0A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.0A)
AGS  A 801 ( 4.8A)
 0.37A 5lvnA-5o0yA:
27.5		 5lvnA-5o0yA:
13.59