SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5o16 AMBC
(Sorangium
cellulosum) 		4 / 8 PHE A 290
ALA A 272
LEU A 221
ASP A 268
 None
 1.11A 2bxkA-5o16A:
undetectable		 2bxkA-5o16A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5o16 AMBC
(Sorangium
cellulosum) 		4 / 7 SER A 243
SER A  81
ARG A 286
GLU A  82
 None
 1.30A 2c8aA-5o16A:
undetectable		 2c8aA-5o16A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5o16 AMBC
(Sorangium
cellulosum) 		4 / 6 SER A 243
SER A  81
ARG A 286
GLU A  82
 None
 1.27A 2c8aC-5o16A:
undetectable		 2c8aC-5o16A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 12 VAL A 116
LEU A  36
VAL A 103
ALA A  74
LEU A  69
 None
 1.11A 4i1rA-5o16A:
undetectable		 4i1rA-5o16A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 9 LEU A 209
HIS A 210
PRO A 211
GLY A 251
LEU A  69
 None
 1.10A 5o96E-5o16A:
undetectable
5o96F-5o16A:
undetectable		 5o96E-5o16A:
22.74
5o96F-5o16A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 12 LEU A  36
SER A  23
LEU A  22
THR A  98
LEU A  99
 None
 0.96A 5twjA-5o16A:
undetectable		 5twjA-5o16A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 12 LEU A  36
SER A  23
THR A  98
LEU A  99
HIS A 117
 None
 0.93A 5twjA-5o16A:
undetectable		 5twjA-5o16A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 12 LEU A  69
SER A 243
VAL A 245
ALA A 287
GLY A 288
 None
 1.06A 5tzoB-5o16A:
undetectable		 5tzoB-5o16A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 11 VAL A 259
ALA A 217
LEU A 270
TRP A 242
ALA A 220
 None
 1.31A 6dk1A-5o16A:
undetectable		 6dk1A-5o16A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 11 VAL A 259
ALA A 217
LEU A 270
TRP A 242
ALA A 220
 None
 1.40A 6dk1B-5o16A:
undetectable		 6dk1B-5o16A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5o16 AMBC
(Sorangium
cellulosum) 		5 / 11 VAL A 259
ALA A 217
LEU A 270
TRP A 242
ALA A 220
 None
 1.28A 6dk1C-5o16A:
undetectable		 6dk1C-5o16A:
24.61