SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 THR A 580
GLY A 599
ALA A 563
THR A 575
ILE A 597
 None
 1.42A 1c9sC-5o1pA:
undetectable
1c9sD-5o1pA:
undetectable		 1c9sC-5o1pA:
8.38
1c9sD-5o1pA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 808
LEU A 763
LEU A 740
ALA A 782
 None
 0.88A 1j8uA-5o1pA:
undetectable		 1j8uA-5o1pA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 487
GLY A 489
ASP A 532
LEU A 554
PRO A 555
 None
 0.84A 1zq9B-5o1pA:
5.9		 1zq9B-5o1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 857
PHE A 692
ARG A 839
 None
 0.87A 2a3aA-5o1pA:
undetectable		 2a3aA-5o1pA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 554
PRO A 555
LEU A 558
ILE A 533
 None
 0.70A 2qd4A-5o1pA:
3.6		 2qd4A-5o1pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 815
VAL A 738
ILE A 680
GLY A 678
ILE A 743
 None
 1.09A 3ekqB-5o1pA:
undetectable		 3ekqB-5o1pA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 797
GLU A 798
LEU A 764
LEU A 803
LEU A 742
 None
 1.17A 3erdA-5o1pA:
undetectable		 3erdA-5o1pA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 797
GLU A 798
LEU A 764
LEU A 803
LEU A 742
 None
 1.16A 3erdB-5o1pA:
undetectable		 3erdB-5o1pA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 798
TRP A 799
LEU A 826
ASN A 644
 None
 1.38A 3k8mA-5o1pA:
2.3		 3k8mA-5o1pA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 809
LEU A 742
LEU A 800
PRO A 654
LEU A 658
 None
 1.04A 3vrmA-5o1pA:
undetectable		 3vrmA-5o1pA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 554
PRO A 555
LEU A 558
ILE A 533
 None
 0.74A 4f4dB-5o1pA:
3.4		 4f4dB-5o1pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 583
SER A 552
LEU A 553
PRO A 555
ASP A 604
 None
 1.48A 4j7xJ-5o1pA:
undetectable		 4j7xJ-5o1pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR A 730
VAL A 738
ILE A 743
LEU A 822
 None
 0.95A 4l1wB-5o1pA:
undetectable		 4l1wB-5o1pA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 903
ILE A 911
PRO A 877
LEU A 601
ILE A 579
 None
 0.97A 4pd4C-5o1pA:
undetectable		 4pd4C-5o1pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 631
TYR A 629
ASP A 604
 None
 0.77A 4rp8C-5o1pA:
undetectable		 4rp8C-5o1pA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 797
GLU A 798
LEU A 764
LEU A 803
LEU A 742
 None
 1.15A 4zn7B-5o1pA:
undetectable		 4zn7B-5o1pA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 HIS A 853
ILE A 616
GLU A 621
VAL A 622
GLU A 627
 None
 1.39A 5igzA-5o1pA:
undetectable		 5igzA-5o1pA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 507
GLU A 506
ASP A 548
ASN A 504
 None
 1.00A 5n5dA-5o1pA:
7.0		 5n5dA-5o1pA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 CYH A 566
MET A 573
ASN A 572
 None
 1.03A 5qh8A-5o1pA:
undetectable		 5qh8A-5o1pA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 855
LYS A 912
GLU A 614
SER A 615
 None
 1.12A 6c06C-5o1pA:
undetectable		 6c06C-5o1pA:
undetectable