SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 7 MET A 466
SER A 483
ALA A 481
ILE A 484
 None
 1.07A 1fxhA-5o2cA:
undetectable
1fxhB-5o2cA:
undetectable		 1fxhA-5o2cA:
18.54
1fxhB-5o2cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 GLU A 228
GLY A 164
VAL A 226
PHE A 149
PHE A 146
 None
 1.11A 1nw3A-5o2cA:
undetectable		 1nw3A-5o2cA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 ILE A 396
ILE A 292
LEU A 295
ILE A 271
ILE A 206
 None
None
GOL  A 602 ( 4.9A)
None
None
 1.05A 1oipA-5o2cA:
undetectable		 1oipA-5o2cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 8 MET A 466
SER A 483
ALA A 481
ILE A 484
 None
 1.01A 1pnlA-5o2cA:
undetectable
1pnlB-5o2cA:
undetectable		 1pnlA-5o2cA:
18.54
1pnlB-5o2cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
PHE A 282
 GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
GOL  A 604 ( 4.5A)
 1.33A 1uwhA-5o2cA:
25.4		 1uwhA-5o2cA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 VAL A 161
ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
 0.64A 1uwjA-5o2cA:
9.8		 1uwjA-5o2cA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 VAL A 161
ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
 0.63A 1uwjB-5o2cA:
8.6		 1uwjB-5o2cA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 9 LEU A 153
VAL A 161
LEU A 225
LEU A 229
MET A 230
 None
None
None
GOL  A 604 ( 4.8A)
None
 0.83A 1xkkA-5o2cA:
25.8		 1xkkA-5o2cA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		3 / 3 ARG A 412
GLU A 433
SER A 344
 None
None
PEG  A 601 (-4.7A)
 0.92A 2xctD-5o2cA:
2.7		 2xctD-5o2cA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 7 TYR A 348
SER A 349
CYH A 351
SER A 369
 None
 1.15A 2xz5A-5o2cA:
undetectable
2xz5B-5o2cA:
undetectable		 2xz5A-5o2cA:
19.79
2xz5B-5o2cA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 8 TYR A 348
SER A 349
CYH A 351
SER A 369
 None
 1.13A 2xz5B-5o2cA:
undetectable
2xz5E-5o2cA:
undetectable		 2xz5B-5o2cA:
19.79
2xz5E-5o2cA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 LEU A 339
VAL A 290
ILE A 281
CYH A 278
LEU A 239
 None
 1.00A 3h0aA-5o2cA:
undetectable		 3h0aA-5o2cA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 VAL A 161
ALA A 174
LEU A 198
THR A 227
PHE A 282
 None
GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
 0.73A 3og7A-5o2cA:
26.3		 3og7A-5o2cA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 5 SER A 143
GLY A 164
GLU A 132
GLU A 172
 None
 1.49A 3raeB-5o2cA:
4.8
3raeD-5o2cA:
undetectable		 3raeB-5o2cA:
22.74
3raeD-5o2cA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 5 VAL A 161
ILE A 206
MET A 230
ILE A 292
 None
 0.34A 4c8bA-5o2cA:
23.8		 4c8bA-5o2cA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 5 VAL A 161
ILE A 292
MET A 230
ILE A 281
 None
 0.94A 4c8bA-5o2cA:
23.8		 4c8bA-5o2cA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.59A 4xv2A-5o2cA:
26.1		 4xv2A-5o2cA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 ALA A 174
LEU A 198
THR A 227
PHE A 282
GLY A 293
 GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.53A 4xv2B-5o2cA:
25.9		 4xv2B-5o2cA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 ILE A 206
GLY A 296
PHE A 209
THR A 227
LEU A 276
 None
GOL  A 603 (-3.6A)
None
GOL  A 604 (-3.9A)
None
 1.16A 5byjA-5o2cA:
undetectable		 5byjA-5o2cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 6 GLU A 214
ASP A 166
ARG A 145
GLY A 144
 None
 0.80A 5cdnC-5o2cA:
3.7
5cdnD-5o2cA:
undetectable		 5cdnC-5o2cA:
19.46
5cdnD-5o2cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 6 GLU A 214
ASP A 166
ARG A 145
GLY A 144
 None
 0.83A 5cdnT-5o2cA:
3.7
5cdnU-5o2cA:
undetectable		 5cdnT-5o2cA:
19.46
5cdnU-5o2cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 VAL A 161
ALA A 174
LEU A 198
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.73A 5cswA-5o2cA:
25.7		 5cswA-5o2cA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 VAL A 161
ALA A 174
LEU A 198
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.72A 5cswB-5o2cA:
26.0		 5cswB-5o2cA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.62A 5hieA-5o2cA:
10.1		 5hieA-5o2cA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.61A 5hieB-5o2cA:
10.1		 5hieB-5o2cA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 GLY A 154
VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.73A 5hieC-5o2cA:
24.8		 5hieC-5o2cA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 12 VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.63A 5hieD-5o2cA:
25.0		 5hieD-5o2cA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		4 / 7 GLY A 154
GLY A 156
VAL A 161
LEU A 178
 None
 0.45A 5izjA-5o2cA:
21.8		 5izjA-5o2cA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 10 GLY A 154
VAL A 161
ALA A 174
LEU A 229
MET A 230
 None
None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.8A)
None
 0.53A 5lw1E-5o2cA:
21.0		 5lw1E-5o2cA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		5 / 9 GLY A 154
VAL A 161
ALA A 174
LEU A 229
MET A 230
 None
None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.8A)
None
 0.42A 5lw1H-5o2cA:
21.2		 5lw1H-5o2cA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 ALA A 174
VAL A 207
LEU A 225
THR A 227
PHE A 282
GLY A 293
 GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.9A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.64A 5vcvA-5o2cA:
23.1		 5vcvA-5o2cA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens) 		6 / 12 LEU A 153
ALA A 174
VAL A 207
LEU A 225
THR A 227
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.9A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.6A)
 0.66A 5vcvA-5o2cA:
23.1		 5vcvA-5o2cA:
23.95