SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 5 LEU A1122
VAL A1030
TYR A1088
THR A1119
 None
 1.36A 1nw3A-5o2dA:
undetectable		 1nw3A-5o2dA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 LEU A1164
LEU A1014
ALA A1128
HIS A1168
ALA A1026
 None
 1.08A 2bm9F-5o2dA:
undetectable		 2bm9F-5o2dA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 ILE A1112
LEU A1137
GLU A1146
PRO A1140
ASN A1142
 None
 1.32A 3eigA-5o2dA:
undetectable		 3eigA-5o2dA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		3 / 3 SER A1048
SER A1042
HIS A1091
 None
 0.85A 3mzeA-5o2dA:
undetectable		 3mzeA-5o2dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 LEU A1077
VAL A1069
ALA A1070
THR A1075
ARG A1098
 None
 1.13A 3n23C-5o2dA:
undetectable		 3n23C-5o2dA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 4 VAL A1065
THR A1064
GLU A1061
GLU A1060
 None
 1.23A 4l78A-5o2dA:
undetectable		 4l78A-5o2dA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5o2d POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 GLU A1177
LEU A1018
LEU A1171
ILE A1148
ALA A1145
 None
None
9HH  A1201 (-4.7A)
9HH  A1201 ( 3.5A)
None
 0.96A 5v0vA-5o2dA:
undetectable		 5v0vA-5o2dA:
15.82