SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		5 / 11 ALA A 209
GLU A 213
VAL B  58
PHE B  47
THR A 210
 None
 1.21A 3fl9C-5o2uA:
undetectable		 3fl9C-5o2uA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		5 / 9 ALA A 209
GLU A 213
VAL B  58
PHE B  47
THR A 210
 None
 1.21A 3fl9H-5o2uA:
undetectable		 3fl9H-5o2uA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		5 / 11 ALA A 209
GLU A 213
VAL B  58
PHE B  47
THR A 210
 None
 1.17A 3jw5A-5o2uA:
undetectable		 3jw5A-5o2uA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		5 / 10 ALA A 209
GLU A 213
VAL B  58
PHE B  47
THR A 210
 None
 1.19A 3jw5B-5o2uA:
undetectable		 3jw5B-5o2uA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		5 / 12 GLU B  46
GLY B  35
GLU A 213
PHE B  67
ASP B  86
 None
 1.07A 4xe5A-5o2uB:
undetectable		 4xe5A-5o2uB:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		3 / 3 VAL B  58
ALA A 209
PHE B  47
 None
 0.89A 4z4iA-5o2uB:
undetectable		 4z4iA-5o2uB:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		4 / 6 SER B  62
GLY A 208
THR A 188
GLU A 187
 None
 1.10A 5btaA-5o2uB:
undetectable
5btaB-5o2uB:
undetectable
5btaC-5o2uB:
undetectable		 5btaA-5o2uB:
15.26
5btaB-5o2uB:
22.78
5btaC-5o2uB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		4 / 5 SER B  62
GLY A 208
THR A 188
GLU A 187
 None
 1.16A 5btiA-5o2uB:
undetectable
5btiB-5o2uB:
undetectable		 5btiA-5o2uB:
15.26
5btiB-5o2uB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		4 / 5 SER B  62
GLY A 208
THR A 188
GLU A 187
 None
 1.16A 5btiC-5o2uB:
2.1
5btiD-5o2uB:
undetectable		 5btiC-5o2uB:
15.26
5btiD-5o2uB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5o2u CAPSID PROTEIN P24
VHH 59H10
(Human
immunodeficiency
virus
1;
Lama
glama) 		3 / 3 VAL B  58
ALA A 209
PHE B  47
 None
 0.90A 5js1A-5o2uB:
undetectable		 5js1A-5o2uB:
9.50