SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 4 ASP A  18
ASP A  38
ASP A   6
GLY A   2
 None
None
None
HIC  A   1 ( 2.4A)
 1.12A 2igtC-5o2xA:
undetectable		 2igtC-5o2xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 12 GLN A  50
ASP A 105
PRO A  52
GLY A 195
LEU A 198
 None
None
MAN  A 304 (-4.0A)
None
None
 1.34A 2nv4A-5o2xA:
undetectable		 2nv4A-5o2xA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 5 ILE A  90
TYR A  93
ILE A 160
HIS A  86
 None
None
None
CU  A 318 ( 3.1A)
 1.24A 3eteB-5o2xA:
undetectable
3eteC-5o2xA:
undetectable		 3eteB-5o2xA:
17.16
3eteC-5o2xA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 11 LEU A 133
GLY A 235
ILE A  90
SER A 231
VAL A 141
 None
None
None
MAN  A 311 (-1.4A)
MAN  A 313 ( 4.9A)
 1.18A 3gyqB-5o2xA:
undetectable		 3gyqB-5o2xA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 7 GLN A 172
PRO A 175
GLN A 176
GLU A 158
 SO4  A 319 (-3.3A)
None
None
None
 1.09A 3l2vA-5o2xA:
undetectable		 3l2vA-5o2xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 8 GLN A 172
PRO A 175
GLN A 176
GLU A 158
 SO4  A 319 (-3.3A)
None
None
None
 1.15A 3oyaA-5o2xA:
undetectable		 3oyaA-5o2xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 12 TYR A  93
GLY A 116
GLY A 118
ASP A 115
PRO A 222
 None
None
None
None
SO4  A 321 (-4.2A)
 1.13A 4blvA-5o2xA:
undetectable		 4blvA-5o2xA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 12 VAL A 232
ASP A 115
ILE A 219
VAL A  91
ILE A 159
 None
 1.45A 4eb6B-5o2xA:
undetectable
4eb6C-5o2xA:
undetectable		 4eb6B-5o2xA:
20.22
4eb6C-5o2xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 7 ILE A 159
TRP A 140
ASP A  92
SER A 231
 None
None
None
MAN  A 311 (-1.4A)
 1.34A 5nr3A-5o2xA:
undetectable		 5nr3A-5o2xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 12 PRO A 220
VAL A  44
PHE A 178
PHE A  77
ILE A  54
 None
 1.41A 6becA-5o2xA:
undetectable
6becB-5o2xA:
undetectable
6becC-5o2xA:
undetectable		 6becA-5o2xA:
18.26
6becB-5o2xA:
18.26
6becC-5o2xA:
18.26