SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		6 / 9 ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
 None
 0.94A 1bcuH-5o32I:
31.9		 1bcuH-5o32I:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		3 / 3 TRP I 399
VAL I 397
TRP I 393
 None
 1.14A 1c4dA-5o32I:
undetectable
1c4dB-5o32I:
undetectable		 1c4dA-5o32I:
6.44
1c4dB-5o32I:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 6 ILE D 318
ARG D 317
TYR D  85
PHE D 100
 None
NAG  D 403 (-4.7A)
None
None
 1.42A 1e73M-5o32D:
undetectable		 1e73M-5o32D:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 12 PHE D 112
VAL D 184
VAL D 114
ALA D 153
ILE D 126
 None
 1.03A 1epbA-5o32D:
undetectable		 1epbA-5o32D:
18.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 12 ASP I 519
VAL I 544
TRP I 546
GLY I 547
GLY I 557
 None
 0.86A 1etrH-5o32I:
31.0		 1etrH-5o32I:
34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 12 HIS I 380
VAL I 544
TRP I 546
GLY I 547
GLY I 557
 None
 0.61A 1etrH-5o32I:
31.0		 1etrH-5o32I:
34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 8 ASP I 519
VAL I 544
GLY I 547
GLY I 557
 None
 0.73A 1f5lA-5o32I:
32.5		 1f5lA-5o32I:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		7 / 12 ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.82A 2p16A-5o32I:
30.9		 2p16A-5o32I:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		7 / 12 TYR I 426
ASP I 519
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.81A 2p16A-5o32I:
30.9		 2p16A-5o32I:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		7 / 12 ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.79A 2w26A-5o32I:
10.9		 2w26A-5o32I:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		7 / 12 TYR I 426
ASP I 519
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.78A 2w26A-5o32I:
10.9		 2w26A-5o32I:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens) 		5 / 12 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
 None
 1.29A 2yzqA-5o32C:
undetectable		 2yzqA-5o32C:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 5 VAL I 540
VAL I 454
THR I 377
THR I 538
 None
 1.24A 3bjwG-5o32I:
undetectable		 3bjwG-5o32I:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 5 VAL I 540
VAL I 454
THR I 377
THR I 538
 None
 1.24A 3bjwD-5o32I:
undetectable		 3bjwD-5o32I:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 12 GLY I 343
GLY I 342
GLN I 485
VAL I 341
LEU I 484
 None
 1.21A 3h52B-5o32I:
undetectable		 3h52B-5o32I:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens) 		5 / 12 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
 None
 1.20A 3kpbA-5o32C:
undetectable		 3kpbA-5o32C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens) 		5 / 12 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
 None
 1.20A 3kpbC-5o32C:
undetectable		 3kpbC-5o32C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens) 		5 / 12 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
 None
 1.16A 3kpdB-5o32C:
undetectable		 3kpdB-5o32C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		3 / 3 VAL I 558
VAL I 544
TRP I 546
 None
 0.96A 3l8lC-5o32I:
undetectable
3l8lD-5o32I:
undetectable		 3l8lC-5o32I:
6.44
3l8lD-5o32I:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		3 / 3 LYS D 319
ARG D 315
ASP D 289
 None
None
CA  D 401 (-3.3A)
 1.06A 3o7wA-5o32D:
undetectable		 3o7wA-5o32D:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 6 VAL I 544
TRP I 546
GLY I 547
GLY I 557
 None
 0.45A 3rxfA-5o32I:
11.9		 3rxfA-5o32I:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 6 ILE I 370
ILE D 285
TRP I 456
TRP I 541
 None
 1.45A 3welA-5o32I:
undetectable		 3welA-5o32I:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens) 		4 / 8 ARG C1215
GLU C1198
GLU C1195
ARG C1192
 None
 1.14A 4bqfB-5o32C:
undetectable		 4bqfB-5o32C:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 12 ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 557
 None
 0.83A 4hfpD-5o32I:
31.2		 4hfpD-5o32I:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		6 / 12 HIS I 380
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
 None
 0.74A 4rn6B-5o32I:
27.8		 4rn6B-5o32I:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens) 		4 / 4 LEU C1214
VAL C1200
GLU C1198
ARG C1182
 None
 1.43A 4ww7A-5o32C:
undetectable		 4ww7A-5o32C:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
COMPLEMENT FACTOR I
(Homo
sapiens) 		4 / 7 ILE I 407
GLY C 122
PHE C 170
PHE C  93
 None
 0.77A 5hieA-5o32I:
undetectable		 5hieA-5o32I:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 11 ARG D 167
PHE D 159
GLY D 162
GLY D 232
GLN D 217
 None
 1.15A 5w97G-5o32D:
undetectable
5w97a-5o32D:
undetectable
5w97b-5o32D:
undetectable		 5w97G-5o32D:
12.73
5w97a-5o32D:
17.95
5w97b-5o32D:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		3 / 3 LYS D 233
ASN D 231
SER D 251
 None
 1.24A 5yw0A-5o32D:
undetectable		 5yw0A-5o32D:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 5o32 COMPLEMENT FACTOR I
(Homo
sapiens) 		5 / 12 GLY I 526
ASP I 429
VAL I 562
ILE I 430
ILE I 375
 None
 0.96A 6dj1B-5o32I:
undetectable		 6dj1B-5o32I:
16.39