SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 5 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.98A 1wrkB-5o33B:
undetectable		 1wrkB-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 7 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.98A 1wrlA-5o33B:
undetectable
1wrlB-5o33B:
undetectable		 1wrlA-5o33B:
17.68
1wrlB-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 6 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.98A 1wrlB-5o33B:
undetectable		 1wrlB-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 5 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.95A 1wrlC-5o33B:
undetectable		 1wrlC-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 7 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.97A 1wrlE-5o33B:
undetectable		 1wrlE-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 7 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 1.00A 1wrlE-5o33B:
undetectable
1wrlF-5o33B:
undetectable		 1wrlE-5o33B:
17.68
1wrlF-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 8 SER B1334
ASN B1335
ILE B1338
TYR B1327
 None
 0.95A 2v57C-5o33B:
undetectable		 2v57C-5o33B:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5o33 KALIRIN
(Rattus
norvegicus) 		5 / 10 PHE B1291
GLU B1245
VAL B1310
TYR B1373
PHE B1314
 None
 1.25A 3r6wA-5o33B:
undetectable
3r6wB-5o33B:
undetectable		 3r6wA-5o33B:
18.72
3r6wB-5o33B:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5o33 KALIRIN
(Rattus
norvegicus) 		4 / 6 LEU B1252
PRO B1366
GLU B1245
TYR B1248
 None
None
None
EDO  B1502 ( 4.5A)
 1.26A 4z4gA-5o33B:
undetectable		 4z4gA-5o33B:
13.71