SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 208
ALA A 257
LEU A 135
PRO A 136
ILE A 265
 None
 1.00A 1dhjB-5o3mA:
undetectable		 1dhjB-5o3mA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 234
LEU A 330
LEU A 212
VAL A 167
ILE A 169
 None
9JE  A 601 ( 4.3A)
None
None
9JE  A 601 ( 4.5A)
 1.09A 1ee2A-5o3mA:
undetectable		 1ee2A-5o3mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 234
LEU A 330
LEU A 212
VAL A 167
ILE A 169
 None
9JE  A 601 ( 4.3A)
None
None
9JE  A 601 ( 4.5A)
 1.11A 1ee2B-5o3mA:
undetectable		 1ee2B-5o3mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 204
ALA A 156
LEU A 155
PHE A 129
ILE A 304
 None
 1.28A 1mx8A-5o3mA:
undetectable		 1mx8A-5o3mA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		3 / 3 GLN A 318
HIS A  76
ARG A  81
 None
 1.01A 1zlqA-5o3mA:
undetectable		 1zlqA-5o3mA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 GLU A 268
ASP A 178
PHE A 129
ARG A 177
 None
 1.11A 2a3bB-5o3mA:
undetectable		 2a3bB-5o3mA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 10 GLY A 332
LEU A 333
LEU A 330
ILE A 218
ARG A  79
 None
None
9JE  A 601 ( 4.3A)
None
None
 1.04A 2f8dA-5o3mA:
undetectable		 2f8dA-5o3mA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 10 GLY A 332
LEU A 333
LEU A 330
ILE A 218
ARG A  79
 None
None
9JE  A 601 ( 4.3A)
None
None
 1.01A 2f8dB-5o3mA:
undetectable		 2f8dB-5o3mA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 224
VAL A 236
ALA A 237
LEU A  86
ILE A 216
 None
 1.10A 2h42B-5o3mA:
undetectable		 2h42B-5o3mA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 263
ILE A 265
LEU A 135
VAL A 306
VAL A 174
 None
 1.03A 2nnhA-5o3mA:
undetectable		 2nnhA-5o3mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 7 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 0.93A 2v2gA-5o3mA:
undetectable
2v2gB-5o3mA:
undetectable		 2v2gA-5o3mA:
18.58
2v2gB-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 7 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 0.92A 2v2gC-5o3mA:
undetectable
2v2gD-5o3mA:
undetectable		 2v2gC-5o3mA:
18.58
2v2gD-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 7 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 0.93A 2v2gC-5o3mA:
undetectable
2v2gD-5o3mA:
undetectable		 2v2gC-5o3mA:
18.58
2v2gD-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 8 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 0.95A 2v41C-5o3mA:
undetectable
2v41D-5o3mA:
undetectable		 2v41C-5o3mA:
18.58
2v41D-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 8 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 0.91A 2v41C-5o3mA:
undetectable
2v41D-5o3mA:
undetectable		 2v41C-5o3mA:
18.58
2v41D-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 7 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 1.00A 2v41E-5o3mA:
undetectable
2v41F-5o3mA:
undetectable		 2v41E-5o3mA:
18.58
2v41F-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 8 THR A 335
PRO A 334
SER A 338
GLU A 394
 None
 0.93A 2v41G-5o3mA:
undetectable
2v41H-5o3mA:
undetectable		 2v41G-5o3mA:
18.58
2v41H-5o3mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 216
VAL A 245
VAL A 167
GLU A 255
ILE A 208
 None
 1.15A 2vn0A-5o3mA:
undetectable		 2vn0A-5o3mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 240
VAL A 236
GLY A 235
VAL A 105
ALA A 215
 None
 1.06A 2yy8A-5o3mA:
undetectable
2yy8B-5o3mA:
2.1		 2yy8A-5o3mA:
17.24
2yy8B-5o3mA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 10 GLU A 326
GLY A 219
VAL A 101
ALA A 100
LEU A  93
 None
 1.20A 3a3yA-5o3mA:
undetectable		 3a3yA-5o3mA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A 190
ILE A 216
TYR A 217
LEU A 184
 None
 1.15A 3adsA-5o3mA:
undetectable		 3adsA-5o3mA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 THR A 168
ASN A 232
ILE A 208
GLY A 152
HIS A 170
 None
 1.19A 3eeyF-5o3mA:
undetectable		 3eeyF-5o3mA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 4 ARG A 241
ASP A   7
ASP A 213
PRO A 214
 None
 1.36A 3fgrB-5o3mA:
undetectable		 3fgrB-5o3mA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A 206
HIS A 170
PRO A 302
LEU A 269
 None
 1.30A 3oi8A-5o3mA:
undetectable		 3oi8A-5o3mA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 4 PRO A 440
LEU A 438
HIS A 327
LEU A 330
 None
None
9JE  A 601 (-4.3A)
9JE  A 601 ( 4.3A)
 1.21A 3vw7A-5o3mA:
undetectable		 3vw7A-5o3mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 365
ILE A 430
ILE A 460
LEU A 400
VAL A 370
 None
 0.93A 3w67A-5o3mA:
undetectable		 3w67A-5o3mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 7 ALA A  77
GLY A  74
GLY A  55
ILE A  54
 None
 0.60A 4eatA-5o3mA:
2.7		 4eatA-5o3mA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 ARG A 132
ASP A 178
ASP A 130
ARG A 177
 None
 1.13A 4kcnA-5o3mA:
undetectable		 4kcnA-5o3mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 ARG A 132
ASP A 178
ASP A 130
ARG A 177
 None
 1.09A 4kcnB-5o3mA:
undetectable		 4kcnB-5o3mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 347
ALA A 346
ALA A 388
LEU A 400
ILE A 398
 None
 1.15A 4lnwA-5o3mA:
undetectable		 4lnwA-5o3mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 347
ALA A 346
ALA A 388
LEU A 400
ILE A 398
 None
 1.17A 4lnxA-5o3mA:
undetectable		 4lnxA-5o3mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 208
ALA A 257
LEU A 135
PRO A 136
ILE A 265
 None
 1.05A 4p3qA-5o3mA:
undetectable		 4p3qA-5o3mA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 SER A 338
LEU A 365
ALA A 356
ASN A 353
ALA A 388
 None
 1.17A 4x1kA-5o3mA:
undetectable
4x1kB-5o3mA:
undetectable		 4x1kA-5o3mA:
21.35
4x1kB-5o3mA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A  12
ARG A  70
ILE A 316
GLU A 262
 None
 1.32A 4zzcA-5o3mA:
undetectable
4zzcB-5o3mA:
undetectable		 4zzcA-5o3mA:
20.04
4zzcB-5o3mA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A  12
ARG A  70
ILE A 316
GLU A 262
 None
 1.35A 4zzcB-5o3mA:
undetectable
4zzcC-5o3mA:
undetectable		 4zzcB-5o3mA:
20.04
4zzcC-5o3mA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		4 / 6 HIS A 327
LEU A 330
CYH A 150
LEU A 320
 9JE  A 601 (-4.3A)
9JE  A 601 ( 4.3A)
None
None
 1.45A 5hrqD-5o3mA:
undetectable
5hrqG-5o3mA:
undetectable
5hrqH-5o3mA:
undetectable		 5hrqD-5o3mA:
4.59
5hrqG-5o3mA:
3.70
5hrqH-5o3mA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 6 ILE A 367
ARG A 420
MET A 417
THR A 418
LEU A 414
 None
9JE  A 602 ( 3.6A)
None
None
None
 1.49A 5z86N-5o3mA:
undetectable
5z86W-5o3mA:
undetectable		 5z86N-5o3mA:
23.71
5z86W-5o3mA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5o3m PROTOCATECHUATE
DECARBOXYLASE
(Klebsiella
pneumoniae) 		5 / 12 TYR A 217
ALA A  82
LEU A  72
ILE A  71
MET A 210
 None
 1.13A 6aybA-5o3mA:
undetectable		 6aybA-5o3mA:
21.81