SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 10 ASP A 606
ASN A 563
GLY A 480
GLY A 516
GLU A 517
 None
 0.98A 1mehA-5o3wA:
undetectable		 1mehA-5o3wA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 HIS A 479
GLY A 560
ASN A 585
GLU A 706
VAL A 568
 None
 1.47A 1qu3A-5o3wA:
undetectable		 1qu3A-5o3wA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 11 ALA A 145
GLY A 189
ILE A 182
VAL A 176
ILE A 158
 None
 1.03A 1sduA-5o3wA:
undetectable		 1sduA-5o3wA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 4 HIS A 238
ASP A 297
ASN A 315
ASP A 257
 None
 1.34A 1wg8A-5o3wA:
0.8		 1wg8A-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.34A 2eimJ-5o3wA:
undetectable		 2eimJ-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.35A 2eimW-5o3wA:
undetectable		 2eimW-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		3 / 3 ARG A  87
SER A 400
TYR A  92
 None
 0.90A 2q2hA-5o3wA:
undetectable
2q2hB-5o3wA:
undetectable		 2q2hA-5o3wA:
undetectable
2q2hB-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 8 TYR A 168
LEU A 169
LEU A 161
ALA A 145
 None
 0.99A 2wekA-5o3wA:
undetectable		 2wekA-5o3wA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.38A 3ag1J-5o3wA:
undetectable		 3ag1J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.33A 3ag2J-5o3wA:
undetectable		 3ag2J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.32A 3ag4J-5o3wA:
undetectable		 3ag4J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 11 ASN A 573
VAL A 628
THR A 645
ILE A 647
LEU A 664
 None
 1.40A 3bf1C-5o3wA:
undetectable
3bf1D-5o3wA:
undetectable		 3bf1C-5o3wA:
undetectable
3bf1D-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		3 / 3 PHE A 106
GLN A 103
PHE A  86
 None
 0.67A 3rv5A-5o3wA:
undetectable		 3rv5A-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 7 GLY A 608
ASP A 606
GLY A 605
HIS A 523
 None
 0.83A 4c5nA-5o3wA:
undetectable		 4c5nA-5o3wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 8 GLY A 608
ASP A 606
GLY A 605
HIS A 523
 None
 0.82A 4c5nC-5o3wA:
2.2		 4c5nC-5o3wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 9 LEU A 374
ALA A 351
LEU A 359
GLN A 313
THR A 311
 None
 1.17A 4ltwA-5o3wA:
undetectable		 4ltwA-5o3wA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 VAL A 326
ILE A 293
VAL A 265
LEU A 292
ALA A 302
 None
 1.03A 4m11B-5o3wA:
undetectable		 4m11B-5o3wA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 LEU A 292
GLY A 307
PHE A 310
GLY A 248
ASP A 247
 None
 1.16A 4n09A-5o3wA:
undetectable		 4n09A-5o3wA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 ASN A 355
GLN A 380
LEU A 359
ALA A 378
LEU A 337
 None
 1.29A 4qckA-5o3wA:
0.0		 4qckA-5o3wA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 GLN A 103
LEU A 132
SER A 133
ASP A 654
 None
 1.23A 4qtuD-5o3wA:
undetectable		 4qtuD-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 GLU A 583
GLU A 559
ALA A 541
PHE A 507
ILE A 512
 None
 1.26A 4xe5A-5o3wA:
2.9		 4xe5A-5o3wA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 7 GLU A 521
ARG A 320
GLU A 340
ALA A 318
 None
 1.04A 4zz8A-5o3wA:
undetectable		 4zz8A-5o3wA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 8 ASN A 683
PRO A 684
PHE A   6
SER A   7
 None
 1.36A 5amiB-5o3wA:
undetectable		 5amiB-5o3wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 GLY A 483
ILE A 512
GLY A 480
GLY A 587
PHE A 535
 None
 1.07A 5d4uA-5o3wA:
undetectable		 5d4uA-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 GLY A 483
ILE A 512
GLY A 480
GLY A 587
PHE A 535
 None
 1.08A 5d4uB-5o3wA:
undetectable		 5d4uB-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 ALA A 145
ALA A 181
ILE A 158
LEU A 173
 None
 0.71A 5jncD-5o3wA:
undetectable		 5jncD-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 PRO A 490
SER A 408
VAL A 445
ASP A 386
GLY A 388
 None
 0.99A 5nnaA-5o3wA:
undetectable		 5nnaA-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 PRO A 490
SER A 408
VAL A 445
ASP A 386
GLY A 388
 None
 1.01A 5nnaB-5o3wA:
undetectable		 5nnaB-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 PRO A 490
SER A 408
VAL A 445
ASP A 386
GLY A 388
 None
 1.07A 5nnaC-5o3wA:
undetectable		 5nnaC-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 PRO A 490
SER A 408
VAL A 445
ASP A 386
GLY A 388
 None
 0.99A 5nnaD-5o3wA:
undetectable		 5nnaD-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.40A 5w97J-5o3wA:
undetectable		 5w97J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.32A 5wauJ-5o3wA:
undetectable		 5wauJ-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.30A 5x19J-5o3wA:
undetectable		 5x19J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.38A 5x1bJ-5o3wA:
undetectable		 5x1bJ-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.37A 5x1bW-5o3wA:
undetectable		 5x1bW-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.36A 5x1fW-5o3wA:
undetectable		 5x1fW-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 ALA A 351
LEU A 374
ASP A 247
GLY A 307
LEU A 252
 None
 1.16A 5x24A-5o3wA:
undetectable		 5x24A-5o3wA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.34A 5z86J-5o3wA:
undetectable		 5z86J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 GLY A 189
SER A 179
VAL A 176
ILE A 158
ASP A 171
 None
 1.21A 6bxmA-5o3wA:
undetectable		 6bxmA-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 8 ASN A 263
VAL A 265
LEU A 292
ILE A 293
 None
 0.94A 6cb4A-5o3wA:
undetectable		 6cb4A-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		5 / 12 GLY A 485
GLY A 516
GLY A 560
ASN A 511
GLU A 559
 None
 1.08A 6gngB-5o3wA:
2.5		 6gngB-5o3wA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5o3w PEPTIDE CYCLASE 1
(Gypsophila
vaccaria) 		4 / 5 TYR A 642
MET A 668
THR A 667
LEU A 664
 None
 1.42A 6nknJ-5o3wA:
undetectable		 6nknJ-5o3wA:
undetectable