SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 11 SER C 358
LEU C 370
LEU C 400
VAL C 334
ILE C 390
 None
 1.35A 1ee2A-5o4gC:
undetectable		 1ee2A-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY C 386
GLY C 411
LEU C 414
GLY C 322
LEU C 352
 None
 1.20A 1jg2A-5o4gC:
undetectable		 1jg2A-5o4gC:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 9 GLY C 442
SER C 420
LEU C 443
PHE C 464
LEU C 472
 None
 1.44A 1y7iA-5o4gC:
undetectable		 1y7iA-5o4gC:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 5 LEU C  24
LEU C  38
LEU C  63
LEU C  52
 None
 1.06A 1yajD-5o4gC:
undetectable		 1yajD-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 TYR C 419
SER C  16
ALA C  15
THR C  19
 None
 1.10A 1yvpB-5o4gC:
undetectable		 1yvpB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 SER C 186
LEU C 120
LEU C 115
LEU C 139
 None
 0.97A 2bfpA-5o4gC:
undetectable		 2bfpA-5o4gC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 ASN C 476
HIS C 473
ASN C 449
ILE C 390
 None
 1.23A 2hkkA-5o4gC:
undetectable		 2hkkA-5o4gC:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 TYR C 419
SER C  16
ALA C  15
THR C  19
 None
 1.08A 2i91A-5o4gC:
undetectable		 2i91A-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 TYR C 419
SER C  16
ALA C  15
THR C  19
 None
 1.07A 2i91B-5o4gC:
undetectable		 2i91B-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY C 502
LEU C 433
GLY C 432
GLY C 500
ILE C 428
 None
 0.99A 2nxeB-5o4gC:
undetectable		 2nxeB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		3 / 3 LEU C  43
PRO C  44
ARG C  25
 None
 0.36A 2qd4B-5o4gC:
undetectable		 2qd4B-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		3 / 3 LEU C  43
PRO C  44
ARG C  25
 None
 0.58A 2qd5A-5o4gC:
undetectable		 2qd5A-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 LEU C 423
ALA C 444
LEU C 439
LEU C 436
ILE C 384
 None
 1.12A 2w9gA-5o4gC:
undetectable		 2w9gA-5o4gC:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 LEU C 423
ALA C 444
LEU C 439
LEU C 436
ILE C 384
 None
 1.13A 2w9hA-5o4gC:
undetectable		 2w9hA-5o4gC:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY C 502
LEU C 433
GLY C 432
GLY C 500
ILE C 428
 None
 1.02A 2zbpA-5o4gC:
undetectable		 2zbpA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 GLY C 322
GLY C 350
GLY C 386
ILE C 409
 None
 0.57A 3d41A-5o4gC:
undetectable		 3d41A-5o4gC:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.24A 3elzB-5o4gC:
undetectable		 3elzB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.21A 3elzC-5o4gC:
undetectable		 3elzC-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.31A 3em0A-5o4gC:
undetectable		 3em0A-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 GLY C 432
GLN C 404
ASP C 399
ILE C 428
 None
 0.91A 3fi0P-5o4gC:
undetectable		 3fi0P-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 11 LEU C 423
ALA C 444
LEU C 439
LEU C 436
ILE C 384
 None
 1.09A 3frbX-5o4gC:
undetectable		 3frbX-5o4gC:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 5 TYR C 267
THR C 268
PHE C 269
LEU C 282
 None
 1.24A 3qelC-5o4gC:
undetectable		 3qelC-5o4gC:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 ILE C 339
SER C 391
GLU C 357
LEU C 323
 None
 0.86A 3ua5B-5o4gC:
undetectable		 3ua5B-5o4gC:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY C 411
GLY C 442
LEU C 443
TYR C 419
LEU C 291
 None
 1.09A 3vywA-5o4gC:
undetectable		 3vywA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY C 411
GLY C 442
LEU C 443
TYR C 419
LEU C 291
 None
 1.12A 3vywB-5o4gC:
undetectable		 3vywB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY C 411
GLY C 442
LEU C 443
TYR C 419
LEU C 291
 None
 1.07A 3vywD-5o4gC:
undetectable		 3vywD-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 LEU C 352
ILE C 384
GLY C 386
PHE C 354
THR C 422
 None
 1.06A 4fakA-5o4gC:
undetectable		 4fakA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 ILE C 126
ALA C 158
ALA C  93
ILE C 145
ILE C 150
 None
 1.02A 4kjjA-5o4gC:
undetectable		 4kjjA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 9 TYR C  28
VAL C  62
ILE C  64
LEU C  21
LEU C  43
 None
 1.48A 4l1xB-5o4gC:
undetectable		 4l1xB-5o4gC:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 LEU C 421
LEU C 388
LEU C 352
ALA C 353
LEU C 426
 None
 1.15A 4ltwA-5o4gC:
undetectable		 4ltwA-5o4gC:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 VAL C  72
LEU C  74
LEU C 115
VAL C  62
LEU C  43
 None
 1.02A 4m11C-5o4gC:
undetectable		 4m11C-5o4gC:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 LEU C  92
VAL C  58
TRP C 183
LEU C 118
 None
 1.12A 4pwdC-5o4gC:
undetectable		 4pwdC-5o4gC:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 5 LEU C 452
GLU C 479
LEU C 471
HIS C 447
 None
 1.26A 4xi3B-5o4gC:
undetectable		 4xi3B-5o4gC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 VAL C 131
TRP C 147
ILE C 150
LEU C  74
 None
 1.07A 4xo7B-5o4gC:
undetectable		 4xo7B-5o4gC:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 LEU C  38
VAL C  34
HIS C  20
LEU C  43
LEU C  49
 None
 1.38A 4yvpB-5o4gC:
undetectable		 4yvpB-5o4gC:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		3 / 3 HIS C  26
SER C 420
ASN C 466
 None
 0.91A 5cprB-5o4gC:
undetectable		 5cprB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 ASN C 262
GLU C 243
HIS C 245
THR C 254
 None
 1.33A 5hqaA-5o4gC:
undetectable		 5hqaA-5o4gC:
9.22