SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5o4m HCGC
(Methanococcus
maripaludis) 		4 / 6 LEU A 131
GLY A 157
ASN A 127
PHE A 126
 None
 0.81A 1xf1B-5o4mA:
undetectable		 1xf1B-5o4mA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 THR A 113
LEU A 131
VAL A 156
VAL A 109
CYH A 155
 SAH  A 301 ( 4.1A)
None
None
None
None
 1.32A 3u9fB-5o4mA:
undetectable
3u9fC-5o4mA:
undetectable		 3u9fB-5o4mA:
22.26
3u9fC-5o4mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 THR A 113
LEU A 131
VAL A 156
VAL A 109
CYH A 155
 SAH  A 301 ( 4.1A)
None
None
None
None
 1.26A 3u9fH-5o4mA:
undetectable
3u9fI-5o4mA:
undetectable		 3u9fH-5o4mA:
22.26
3u9fI-5o4mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 THR A 113
LEU A 131
VAL A 156
VAL A 109
CYH A 155
 SAH  A 301 ( 4.1A)
None
None
None
None
 1.25A 3u9fJ-5o4mA:
undetectable
3u9fK-5o4mA:
undetectable		 3u9fJ-5o4mA:
22.26
3u9fK-5o4mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 CYH A 155
THR A 113
LEU A 131
VAL A 156
VAL A 109
 None
SAH  A 301 ( 4.1A)
None
None
None
 1.36A 3u9fP-5o4mA:
undetectable
3u9fS-5o4mA:
undetectable		 3u9fP-5o4mA:
22.26
3u9fS-5o4mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 11 LEU A 246
LEU A 242
ILE A 245
SER A 234
LEU A 205
 None
 1.15A 4dm8A-5o4mA:
undetectable		 4dm8A-5o4mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5o4m HCGC
(Methanococcus
maripaludis) 		4 / 6 ILE A 132
ILE A  69
ILE A  57
LEU A  37
 None
 0.71A 4o8fB-5o4mA:
undetectable		 4o8fB-5o4mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 PHE A 126
ILE A 123
LEU A 108
VAL A  47
GLY A 117
 None
None
None
None
SAH  A 301 (-3.4A)
 1.05A 5byjA-5o4mA:
undetectable		 5byjA-5o4mA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		9 / 12 GLY A  49
TYR A  51
LEU A  52
ILE A  73
LEU A  91
THR A 113
GLY A 117
GLY A 176
PHE A 213
 SAH  A 301 (-3.4A)
None
SAH  A 301 ( 4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.9A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-3.4A)
9KH  A 302 ( 3.3A)
SAH  A 301 (-4.8A)
 0.40A 5d4uA-5o4mA:
36.1		 5d4uA-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 TYR A  51
LEU A  52
GLY A 116
GLY A 176
PHE A 213
 None
SAH  A 301 ( 4.3A)
None
9KH  A 302 ( 3.3A)
SAH  A 301 (-4.8A)
 0.89A 5d4uA-5o4mA:
36.1		 5d4uA-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		4 / 4 LYS A  29
ASP A  72
GLU A 134
THR A 177
 SAH  A 301 (-2.8A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
 0.31A 5d4uA-5o4mA:
36.1		 5d4uA-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		9 / 12 GLY A  49
TYR A  51
LEU A  52
ILE A  73
LEU A  91
THR A 113
GLY A 117
GLY A 176
PHE A 213
 SAH  A 301 (-3.4A)
None
SAH  A 301 ( 4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.9A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-3.4A)
9KH  A 302 ( 3.3A)
SAH  A 301 (-4.8A)
 0.42A 5d4uB-5o4mA:
35.8		 5d4uB-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 12 TYR A  51
LEU A  52
GLY A 116
GLY A 176
PHE A 213
 None
SAH  A 301 ( 4.3A)
None
9KH  A 302 ( 3.3A)
SAH  A 301 (-4.8A)
 0.95A 5d4uB-5o4mA:
35.8		 5d4uB-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		4 / 4 LYS A  29
ASP A  72
GLU A 134
THR A 177
 SAH  A 301 (-2.8A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
 0.36A 5d4uB-5o4mA:
35.8		 5d4uB-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		8 / 12 GLY A  49
TYR A  51
LEU A  52
ILE A  73
LEU A  91
THR A 113
GLY A 117
GLY A 176
 SAH  A 301 (-3.4A)
None
SAH  A 301 ( 4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.9A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-3.4A)
9KH  A 302 ( 3.3A)
 0.30A 5d4uC-5o4mA:
36.4		 5d4uC-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		4 / 4 LYS A  29
ASP A  72
GLU A 134
THR A 177
 SAH  A 301 (-2.8A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
 0.39A 5d4uC-5o4mA:
36.4		 5d4uC-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		8 / 12 GLY A  49
TYR A  51
LEU A  52
ILE A  73
LEU A  91
THR A 113
GLY A 117
GLY A 176
 SAH  A 301 (-3.4A)
None
SAH  A 301 ( 4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.9A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-3.4A)
9KH  A 302 ( 3.3A)
 0.33A 5d4uD-5o4mA:
36.2		 5d4uD-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5o4m HCGC
(Methanococcus
maripaludis) 		4 / 4 LYS A  29
ASP A  72
GLU A 134
THR A 177
 SAH  A 301 (-2.8A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
 0.30A 5d4uD-5o4mA:
36.2		 5d4uD-5o4mA:
51.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5o4m HCGC
(Methanococcus
maripaludis) 		5 / 10 GLY A 176
THR A 165
GLN A  74
LEU A 112
LEU A 163
 9KH  A 302 ( 3.3A)
None
None
SAH  A 301 (-4.9A)
None
 1.18A 5fhzC-5o4mA:
2.1		 5fhzC-5o4mA:
19.55