SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 6 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.27A 1nsiA-5o51A:
undetectable
1nsiB-5o51A:
undetectable		 1nsiA-5o51A:
10.92
1nsiB-5o51A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 6 PHE A1106
GLU A1090
ARG A1115
ILE A1136
 None
 1.26A 1nsiA-5o51A:
undetectable
1nsiB-5o51A:
undetectable		 1nsiA-5o51A:
10.92
1nsiB-5o51A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.24A 2nsiA-5o51A:
undetectable
2nsiB-5o51A:
undetectable		 2nsiA-5o51A:
10.92
2nsiB-5o51A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 PHE A1106
GLU A1090
ARG A1115
ILE A1136
 None
 1.26A 2nsiA-5o51A:
undetectable
2nsiB-5o51A:
undetectable		 2nsiA-5o51A:
10.92
2nsiB-5o51A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.25A 2nsiC-5o51A:
undetectable
2nsiD-5o51A:
undetectable		 2nsiC-5o51A:
10.92
2nsiD-5o51A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.27A 3e7gA-5o51A:
undetectable
3e7gB-5o51A:
undetectable		 3e7gA-5o51A:
11.14
3e7gB-5o51A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 PHE A1106
GLU A1090
ARG A1115
ILE A1136
 None
 1.31A 3e7gA-5o51A:
undetectable
3e7gB-5o51A:
undetectable		 3e7gA-5o51A:
11.14
3e7gB-5o51A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.30A 3e7gC-5o51A:
undetectable
3e7gD-5o51A:
undetectable		 3e7gC-5o51A:
11.14
3e7gD-5o51A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 8 PHE A1106
GLU A1090
ARG A1115
ILE A1136
 None
 1.33A 3e7gC-5o51A:
undetectable
3e7gD-5o51A:
undetectable		 3e7gC-5o51A:
11.14
3e7gD-5o51A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		5 / 11 ALA A1079
LEU A1068
GLU A1082
VAL A1084
PHE A1103
 None
 1.28A 3jw5A-5o51A:
undetectable		 3jw5A-5o51A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		5 / 11 LEU A1067
PHE A1054
ILE A1089
PHE A1105
SER A1074
 None
 1.22A 3ko0E-5o51A:
undetectable
3ko0F-5o51A:
undetectable
3ko0G-5o51A:
undetectable
3ko0H-5o51A:
undetectable		 3ko0E-5o51A:
12.87
3ko0F-5o51A:
12.87
3ko0G-5o51A:
12.87
3ko0H-5o51A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 8 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.21A 4cx7A-5o51A:
undetectable
4cx7B-5o51A:
undetectable		 4cx7A-5o51A:
10.92
4cx7B-5o51A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 PHE A1106
GLU A1090
ARG A1115
ILE A1136
 None
 1.28A 4nosA-5o51A:
undetectable
4nosB-5o51A:
undetectable		 4nosA-5o51A:
11.39
4nosB-5o51A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 7 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.35A 4nosC-5o51A:
undetectable
4nosD-5o51A:
undetectable		 4nosC-5o51A:
11.39
4nosD-5o51A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		4 / 6 PHE A1106
GLU A1090
ARG A1115
ILE A1136
 None
 1.36A 4nosC-5o51A:
undetectable
4nosD-5o51A:
undetectable		 4nosC-5o51A:
11.39
4nosD-5o51A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE
(Aspergillus
fumigatus) 		3 / 3 ASN A1162
ASP A1184
ASP A 895
 None
 0.78A 4obwD-5o51A:
undetectable		 4obwD-5o51A:
undetectable