SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		3 / 3 SER A 216
ASP A 325
CYH A 301
 PLP  A 601 ( 3.9A)
PLP  A 601 (-3.0A)
None
 1.18A 2br4E-5o5cA:
2.6		 2br4E-5o5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 11 SER A 283
ILE A 282
VAL A 244
LEU A 247
VAL A 251
 None
 0.72A 2kawA-5o5cA:
undetectable		 2kawA-5o5cA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 8 ILE A 405
PRO A 485
TYR A 299
GLY A 302
 None
 0.92A 3em0B-5o5cA:
undetectable		 3em0B-5o5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 5 LEU A 303
GLY A 300
PHE A 402
ARG A 312
 None
 1.17A 3smtA-5o5cA:
undetectable		 3smtA-5o5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 ALA A 263
VAL A 207
ASP A 320
ALA A 319
ASP A 277
 None
 1.48A 4df3B-5o5cA:
undetectable		 4df3B-5o5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		6 / 12 VAL A 466
ALA A 465
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.27A 4mm4A-5o5cA:
undetectable		 4mm4A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		6 / 12 VAL A 466
ALA A 465
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.28A 4mm4B-5o5cA:
undetectable		 4mm4B-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 9 VAL A 466
ALA A 465
PHE A 460
SER A  58
GLY A 463
 None
 1.31A 4mm5A-5o5cA:
undetectable		 4mm5A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 VAL A 466
ALA A 465
TYR A 104
PHE A 460
SER A  58
 None
 1.27A 4mm6A-5o5cA:
undetectable		 4mm6A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 VAL A 466
ALA A 465
TYR A 104
SER A  58
GLY A 463
 None
 1.27A 4mm6A-5o5cA:
undetectable		 4mm6A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 10 VAL A 466
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.20A 4mm7A-5o5cA:
undetectable		 4mm7A-5o5cA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 10 VAL A 466
TYR A 104
PHE A 460
SER A  58
GLY A 463
 None
 1.11A 4mmcA-5o5cA:
undetectable		 4mmcA-5o5cA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 9 VAL A 466
ALA A 465
PHE A 460
SER A  58
GLY A 463
 None
 1.28A 4mmeB-5o5cA:
undetectable		 4mmeB-5o5cA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 9 VAL A 466
ALA A 465
PHE A 460
SER A  58
GLY A 463
 None
 1.33A 4mmfB-5o5cA:
undetectable		 4mmfB-5o5cA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 6 LEU A 259
GLU A 250
VAL A 264
ALA A 263
 None
 1.13A 4nkvC-5o5cA:
undetectable		 4nkvC-5o5cA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 5 GLY A 337
THR A 165
HIS A 327
GLY A 168
 None
None
PLP  A 601 (-4.0A)
PLP  A 601 (-3.2A)
 1.19A 4v20A-5o5cA:
undetectable		 4v20A-5o5cA:
undetectable