SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5o5i ROUNDABOUT HOMOLOG 1
(Homo
sapiens) 		5 / 12 ILE A 502
ILE A 540
LEU A 474
PRO A 461
ILE A 512
 None
 0.98A 1dhjB-5o5iA:
undetectable		 1dhjB-5o5iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5o5i ROUNDABOUT HOMOLOG 1
(Homo
sapiens) 		4 / 6 ALA A 527
ILE A 486
VAL A 483
ASN A 507
 None
 1.18A 3nneG-5o5iA:
undetectable		 3nneG-5o5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5o5i ROUNDABOUT HOMOLOG 1
(Homo
sapiens) 		4 / 5 GLY A 470
ILE A 512
LYS A 503
GLN A 511
 None
 1.09A 4ma8C-5o5iA:
undetectable		 4ma8C-5o5iA:
17.07