SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		4 / 7 GLU A 390
GLU A 394
TRP A 419
LEU A 402
 None
 1.25A 1q0yH-5o5lA:
undetectable
1q0yL-5o5lA:
undetectable		 1q0yH-5o5lA:
19.53
1q0yL-5o5lA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		6 / 11 GLY A 355
ALA A 354
ASP A 365
VAL A 305
GLY A 368
VAL A 308
 None
 1.37A 1t7jA-5o5lA:
undetectable		 1t7jA-5o5lA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		6 / 12 GLY A 355
ALA A 354
ASP A 365
VAL A 305
GLY A 368
VAL A 308
 None
 1.43A 3el5B-5o5lA:
undetectable		 3el5B-5o5lA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 11 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.31A 5g6sA-5o5lA:
undetectable
5g6sG-5o5lA:
undetectable		 5g6sA-5o5lA:
23.08
5g6sG-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 11 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.27A 5g6sB-5o5lA:
undetectable
5g6sC-5o5lA:
undetectable		 5g6sB-5o5lA:
23.08
5g6sC-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 12 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.31A 5g6sB-5o5lA:
undetectable
5g6sC-5o5lA:
undetectable		 5g6sB-5o5lA:
23.08
5g6sC-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 10 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.30A 5g6sD-5o5lA:
undetectable
5g6sF-5o5lA:
undetectable		 5g6sD-5o5lA:
23.08
5g6sF-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 11 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.31A 5g6sE-5o5lA:
undetectable
5g6sH-5o5lA:
undetectable		 5g6sE-5o5lA:
23.08
5g6sH-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 10 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.16A 5g6sD-5o5lA:
undetectable
5g6sF-5o5lA:
undetectable		 5g6sD-5o5lA:
23.08
5g6sF-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 10 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.26A 5g6sA-5o5lA:
undetectable
5g6sG-5o5lA:
undetectable		 5g6sA-5o5lA:
23.08
5g6sG-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 12 PHE A 283
TYR A 280
LEU A 279
ALA A 330
ILE A 257
 None
 0.93A 5h8tA-5o5lA:
undetectable		 5h8tA-5o5lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 12 ILE A 243
PRO A 228
VAL A 356
GLY A 355
TYR A 247
 None
SO4  A 504 (-4.4A)
None
None
None
 1.17A 5nnaB-5o5lA:
undetectable		 5nnaB-5o5lA:
23.00