SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		5 / 12 LEU A 209
ASP A 202
ALA A 262
PHE A 164
VAL A 255
 None
 1.41A 2g70B-5o5oA:
undetectable		 2g70B-5o5oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		5 / 12 LEU A 209
ASP A 202
ALA A 262
PHE A 164
VAL A 255
 None
 1.42A 2g72A-5o5oA:
undetectable		 2g72A-5o5oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		3 / 3 LEU A   3
PRO A  80
ARG A  42
 None
 0.61A 2qd4B-5o5oA:
undetectable		 2qd4B-5o5oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		3 / 3 LEU A   3
PRO A  80
ARG A  42
 None
 0.65A 2qd5A-5o5oA:
undetectable		 2qd5A-5o5oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		5 / 9 LEU A  82
PRO A  80
LEU A   3
LEU A  74
ALA A  70
 None
 1.13A 2vcvE-5o5oA:
undetectable		 2vcvE-5o5oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		5 / 9 LEU A  82
PRO A  80
LEU A   3
LEU A  74
ALA A  70
 None
 1.07A 2vcvI-5o5oA:
undetectable		 2vcvI-5o5oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		4 / 7 LEU A  92
ASP A  86
THR A 136
ALA A  87
 None
 1.33A 3mbgA-5o5oA:
undetectable
3mbgB-5o5oA:
undetectable		 3mbgA-5o5oA:
18.18
3mbgB-5o5oA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		4 / 6 TYR A 264
GLN A 260
ILE A 219
SER A 267
 None
 1.27A 3peoG-5o5oA:
undetectable		 3peoG-5o5oA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		3 / 3 THR A 222
HIS A 252
LEU A 209
 None
 0.69A 5axdA-5o5oA:
undetectable		 5axdA-5o5oA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		3 / 3 ALA A  70
ASN A  73
LEU A  74
 None
 0.38A 5i1oC-5o5oA:
undetectable		 5i1oC-5o5oA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		5 / 12 LEU A 261
PHE A 265
LEU A 233
LEU A 160
PHE A 164
 None
 1.26A 5ieoA-5o5oA:
undetectable		 5ieoA-5o5oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5o5o RNASE ADAPTER
PROTEIN RAPZ
(Escherichia
coli) 		4 / 4 LEU A 132
MET A 147
ILE A   5
LEU A  85
 None
 1.21A 5nfpA-5o5oA:
undetectable		 5nfpA-5o5oA:
21.98