SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5o60 50S RIBOSOMAL
PROTEIN L23
50S RIBOSOMAL
PROTEIN L29
(Mycolicibacteriu
m
smegmatis;
Mycolicibacteriu
m
smegmatis) 		4 / 8 SER U  37
PHE Z  30
ALA U  45
ILE U  46
 None
 0.98A 1gm7A-5o60U:
undetectable
1gm7B-5o60U:
undetectable		 1gm7A-5o60U:
17.59
1gm7B-5o60U:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR I  77
LEU I  69
PHE I  73
THR I  23
GLY I 108
 None
 1.37A 1h4oA-5o60I:
undetectable
1h4oB-5o60I:
undetectable		 1h4oA-5o60I:
25.26
1h4oB-5o60I:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5o60 50S RIBOSOMAL
PROTEIN L6
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY G   5
ILE G   4
GLN G   7
VAL G   9
 None
A  A2973 ( 4.5A)
None
None
 1.03A 1rs7B-5o60G:
undetectable		 1rs7B-5o60G:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER W 163
ILE W 162
LEU W 170
VAL W 178
VAL W 110
 None
 1.02A 2nnhA-5o60W:
undetectable		 2nnhA-5o60W:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU W 144
GLY W 160
ALA W 159
VAL W 110
ILE W 131
 None
 0.97A 2pymA-5o60W:
undetectable		 2pymA-5o60W:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU W 144
GLY W 160
ALA W 159
VAL W 110
ILE W 131
 None
 0.96A 2pymB-5o60W:
undetectable		 2pymB-5o60W:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU W 144
GLY W 160
ALA W 159
VAL W 110
ILE W 131
 None
 0.99A 2pynA-5o60W:
undetectable		 2pynA-5o60W:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU W 144
GLY W 160
ALA W 159
VAL W 110
ILE W 131
 None
 0.98A 2pynB-5o60W:
undetectable		 2pynB-5o60W:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU W 144
GLY W 160
ALA W 159
VAL W 110
ILE W 131
 None
 0.98A 2q63B-5o60W:
undetectable		 2q63B-5o60W:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU W 144
GLY W 160
ALA W 159
VAL W 110
ILE W 131
 None
 0.99A 2qakB-5o60W:
undetectable		 2qakB-5o60W:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR I  77
LEU I  69
PHE I  73
THR I  23
GLY I 108
 None
 1.39A 2vl2A-5o60I:
undetectable
2vl2C-5o60I:
undetectable		 2vl2A-5o60I:
23.08
2vl2C-5o60I:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU F 177
LEU F  11
VAL F 163
SER F 112
PHE F 182
 None
 1.07A 2w9hA-5o60F:
undetectable		 2w9hA-5o60F:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5o60 50S RIBOSOMAL
PROTEIN L28
(Mycolicibacteriu
m
smegmatis) 		4 / 5 SER Y  26
PRO Y  12
GLY Y  13
TRP Y  29
 G  A 188 ( 2.6A)
A  A1480 ( 4.5A)
G  A 483 ( 3.4A)
G  A 483 ( 3.4A)
 0.97A 2y7kB-5o60Y:
undetectable		 2y7kB-5o60Y:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA F  54
ASP F  53
GLY F  48
VAL F  74
ILE F  57
 None
None
G  A2531 ( 3.5A)
C  B  42 ( 4.8A)
None
 1.18A 3em4B-5o60F:
undetectable		 3em4B-5o60F:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA F 167
LEU F 177
ILE F  19
ARG F  14
TYR F  29
 None
 1.44A 3ia4A-5o60F:
undetectable		 3ia4A-5o60F:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU F  64
THR F  68
VAL F  96
VAL F 163
PHE F 137
 None
None
C  B  43 ( 3.7A)
None
None
 1.41A 3tbgC-5o60F:
undetectable		 3tbgC-5o60F:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5o60 50S RIBOSOMAL
PROTEIN L23
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS U  80
VAL U  33
HIS U  34
 C  A1818 ( 3.1A)
None
A  A  68 ( 4.4A)
 1.19A 3tj7A-5o60U:
undetectable		 3tj7A-5o60U:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5o60 50S RIBOSOMAL
PROTEIN L10
50S RIBOSOMAL
PROTEIN L11
(Mycolicibacteriu
m
smegmatis;
Mycolicibacteriu
m
smegmatis) 		3 / 3 ASN J 119
ALA I  37
ARG I  41
 G  A1176 ( 3.4A)
U  A1200 ( 3.4A)
None
 0.84A 3tj7C-5o60J:
undetectable
3tj7D-5o60J:
undetectable		 3tj7C-5o60J:
21.46
3tj7D-5o60J:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5o60 50S RIBOSOMAL
PROTEIN L6
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY G   5
ILE G   4
GLN G   7
VAL G   9
 None
A  A2973 ( 4.5A)
None
None
 0.98A 4d39B-5o60G:
undetectable		 4d39B-5o60G:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA F  60
ALA F  50
GLY F  48
ILE F  92
GLY F  93
 None
None
G  A2531 ( 3.5A)
U  A2536 ( 4.1A)
U  A2536 ( 4.1A)
 1.07A 4eatB-5o60F:
undetectable		 4eatB-5o60F:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5o60 50S RIBOSOMAL
PROTEIN L24
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS V  32
TYR V  27
ARG V  30
 A  A 566 ( 4.0A)
None
A  A 567 ( 4.9A)
 0.67A 4gc9A-5o60V:
undetectable		 4gc9A-5o60V:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU I  36
ARG I  40
ILE I  79
ASN I  54
 A  A1202 ( 4.9A)
G  A1201 ( 3.5A)
None
G  A1225 ( 3.2A)
 1.25A 4i00A-5o60I:
undetectable		 4i00A-5o60I:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU F 107
PHE F 182
ALA F 179
GLY F 173
LEU F 176
 None
 1.28A 4j7xB-5o60F:
undetectable		 4j7xB-5o60F:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5o60 50S RIBOSOMAL
PROTEIN L6
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY G   5
ILE G   4
GLN G   7
VAL G   9
 None
A  A2973 ( 4.5A)
None
None
 1.01A 4kcnA-5o60G:
undetectable		 4kcnA-5o60G:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU I  56
THR I  50
ALA I  52
THR I  77
 None
 0.92A 4pwjB-5o60I:
undetectable		 4pwjB-5o60I:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA F 167
LEU F 177
ILE F  19
ARG F  14
TYR F  29
 None
 1.17A 4qlgA-5o60F:
undetectable		 4qlgA-5o60F:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU I  56
THR I  50
ALA I  52
THR I  77
 None
 0.99A 5bojB-5o60I:
undetectable		 5bojB-5o60I:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE W  54
SER W  60
HIS W  61
LEU W  11
 None
 1.01A 5dzke-5o60W:
undetectable
5dzks-5o60W:
undetectable		 5dzke-5o60W:
19.38
5dzks-5o60W:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA I  80
THR I  23
VAL I  82
VAL I 120
 None
 0.90A 5eckA-5o60I:
undetectable		 5eckA-5o60I:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5o60 50S RIBOSOMAL
PROTEIN L10
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA I  80
THR I  23
VAL I  82
VAL I 120
 None
 0.84A 5eckD-5o60I:
undetectable		 5eckD-5o60I:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5o60 50S RIBOSOMAL
PROTEIN L24
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL V  83
LYS V  99
ALA V  98
VAL V  73
 None
A  A 380 ( 2.4A)
None
None
 1.06A 5i8fA-5o60V:
undetectable		 5i8fA-5o60V:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ARG W  59
ALA W  55
LEU W  58
GLY W  62
ILE W  71
 U  A1158 ( 4.5A)
None
None
None
None
 1.19A 5oy01-5o60W:
undetectable
5oy07-5o60W:
undetectable		 5oy01-5o60W:
18.65
5oy07-5o60W:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE F  27
ALA F 167
GLY F 133
TYR F 135
 None
 0.87A 5uxdA-5o60F:
undetectable		 5uxdA-5o60F:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA W 135
VAL W 100
TYR W  38
ASP W  96
THR W  80
 None
None
A  B  74 ( 4.2A)
G  B  76 ( 3.4A)
None
 1.21A 5vlmD-5o60W:
undetectable		 5vlmD-5o60W:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE W  92
ASN W   9
LEU W  79
ALA W  65
LEU W  67
 None
 1.25A 5y7pB-5o60W:
undetectable		 5y7pB-5o60W:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE W  92
ASN W   9
LEU W  79
ALA W  65
LEU W  67
 None
 1.27A 5y7pD-5o60W:
undetectable		 5y7pD-5o60W:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5o60 50S RIBOSOMAL
PROTEIN L23
50S RIBOSOMAL
PROTEIN L29
(Mycolicibacteriu
m
smegmatis;
Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU Z  27
ARG Z  23
ARG U   8
ASP Z  20
 None
 1.25A 5zw4A-5o60Z:
undetectable		 5zw4A-5o60Z:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o60 50S RIBOSOMAL
PROTEIN L25
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE W 157
VAL W 148
ALA W 118
THR W 119
 None
 0.86A 6cduC-5o60W:
undetectable
6cduD-5o60W:
undetectable		 6cduC-5o60W:
20.91
6cduD-5o60W:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5o60 50S RIBOSOMAL
PROTEIN L5
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU F  64
MET F 159
VAL F  43
LEU F 110
ILE F 161
 None
 1.39A 6fdyU-5o60F:
undetectable		 6fdyU-5o60F:
20.43