SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 248
LEU A 247
ILE A 244
CYH A 376
 None
 1.06A 1sbrA-5o6bA:
undetectable
1sbrB-5o6bA:
undetectable		 1sbrA-5o6bA:
21.94
1sbrB-5o6bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 258
THR A 262
GLY A 261
GLN A 418
PHE A 424
 None
ADP  A1001 (-4.3A)
ADP  A1001 ( 3.3A)
None
None
 1.32A 2hmaA-5o6bA:
undetectable		 2hmaA-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 734
ASP A 341
SER A 265
GLY A 377
 ALF  A1002 (-2.6A)
MG  A1003 ( 3.9A)
MG  A1003 ( 2.1A)
None
 1.02A 2j2pD-5o6bA:
undetectable
2j2pF-5o6bA:
undetectable		 2j2pD-5o6bA:
18.81
2j2pF-5o6bA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 331
GLY A 298
ASP A 341
VAL A 340
GLY A 291
 None
None
MG  A1003 ( 3.9A)
None
None
 1.05A 3d20A-5o6bA:
undetectable		 3d20A-5o6bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 709
ALA A 293
GLU A 342
ASP A 378
ALA A 260
 ALF  A1002 (-3.0A)
None
ALF  A1002 (-3.4A)
None
ALF  A1002 (-3.1A)
 1.32A 3nmuA-5o6bA:
undetectable
3nmuF-5o6bA:
undetectable		 3nmuA-5o6bA:
undetectable
3nmuF-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 696
VAL A 673
PHE A 661
VAL A 521
PHE A 542
 None
 1.40A 3u9fH-5o6bA:
undetectable
3u9fI-5o6bA:
undetectable		 3u9fH-5o6bA:
undetectable
3u9fI-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 249
VAL A 339
ILE A 374
ILE A 245
GLU A 270
 None
 1.26A 4a99A-5o6bA:
undetectable
4a99C-5o6bA:
undetectable		 4a99A-5o6bA:
16.13
4a99C-5o6bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 267
LEU A 237
ILE A 374
GLN A 372
VAL A 274
 None
ADP  A1001 ( 4.9A)
None
None
None
 1.07A 4f4dA-5o6bA:
undetectable		 4f4dA-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 726
GLN A 727
LEU A 732
SER A 463
ILE A 704
 None
 1.16A 4pb1A-5o6bA:
undetectable		 4pb1A-5o6bA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 726
GLN A 727
LEU A 732
SER A 463
ILE A 704
 None
 1.19A 4pd5A-5o6bA:
undetectable		 4pd5A-5o6bA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 534
ASN A 526
THR A 290
GLY A 291
ALA A 294
GLY A 299
 None
 1.47A 4pm9A-5o6bA:
undetectable		 4pm9A-5o6bA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 379
VAL A 340
ASP A 341
SER A 344
GLY A 377
 None
None
MG  A1003 ( 3.9A)
None
None
 1.27A 4xnxA-5o6bA:
undetectable		 4xnxA-5o6bA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 379
VAL A 340
ASP A 341
SER A 344
GLY A 377
 None
None
MG  A1003 ( 3.9A)
None
None
 1.27A 4xp1A-5o6bA:
undetectable		 4xp1A-5o6bA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8A-5o6bA:
undetectable		 5hm8A-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8B-5o6bA:
undetectable		 5hm8B-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8C-5o6bA:
undetectable		 5hm8C-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8D-5o6bA:
undetectable		 5hm8D-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8E-5o6bA:
undetectable		 5hm8E-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8F-5o6bA:
undetectable		 5hm8F-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.23A 5hm8G-5o6bA:
undetectable		 5hm8G-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.16A 5hm8H-5o6bA:
undetectable		 5hm8H-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 258
GLN A 413
LYS A 264
 None
None
ALF  A1002 ( 2.7A)
 0.94A 5imsB-5o6bA:
undetectable		 5imsB-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 373
ALA A 401
ILE A 343
ALA A 396
ILE A 302
 None
 0.97A 5xiwB-5o6bA:
undetectable		 5xiwB-5o6bA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5o6b ATP-DEPENDENT DNA
HELICASE PIF1
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 725
GLY A 726
LEU A 433
GLY A 434
 None
 0.60A 6mdqA-5o6bA:
undetectable		 6mdqA-5o6bA:
18.82