SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		4 / 5 LEU A4616
CYH A4579
ALA A4581
CYH A4582
 None
ZN  A4705 (-2.3A)
None
ZN  A4705 (-2.3A)
 1.15A 1mz9D-5o6cA:
undetectable		 1mz9D-5o6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 PHE A4570
CYH A4572
HIS A4583
 None
 1.11A 3u9fF-5o6cA:
undetectable		 3u9fF-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 PHE A4556
CYH A4631
HIS A4552
 None
ZN  A4704 (-2.3A)
ZN  A4704 (-3.2A)
 0.99A 3u9fG-5o6cA:
undetectable		 3u9fG-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 PHE A4570
CYH A4572
HIS A4583
 None
 1.03A 3u9fG-5o6cA:
undetectable		 3u9fG-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 PHE A4570
CYH A4572
HIS A4583
 None
 1.11A 3u9fL-5o6cA:
undetectable		 3u9fL-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 PHE A4556
CYH A4631
HIS A4552
 None
ZN  A4704 (-2.3A)
ZN  A4704 (-3.2A)
 0.96A 3u9fS-5o6cA:
undetectable		 3u9fS-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 PHE A4570
CYH A4572
HIS A4583
 None
 1.01A 3u9fS-5o6cA:
undetectable		 3u9fS-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		4 / 4 ILE A4444
ASN A4445
ILE A4447
VAL A4448
 None
 1.10A 4uy87-5o6cA:
undetectable		 4uy87-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		3 / 3 ALA A4512
TYR A4513
PRO A4428
 None
 0.72A 4zdyA-5o6cA:
undetectable		 4zdyA-5o6cA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		5 / 9 TYR A4513
GLY A4516
GLY A4515
ALA A4568
VAL A4569
 None
 1.34A 5v3cA-5o6cA:
undetectable		 5v3cA-5o6cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens) 		4 / 7 HIS A4583
ARG A4533
GLU A4534
ASP A4531
 None
 1.29A 6mn4F-5o6cA:
undetectable		 6mn4F-5o6cA:
undetectable